Use of Tamoxifen in Systemic Mastocytosis

ClinicalTrials.gov ID: NCT01334996

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Official title

Treatment of Systemic Mastocytosis With Tamoxifen

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

In this study, the investigators will determine the utility of Tamoxifen, a non-cytotoxic agent, to improve quality of life, biochemical parameters, and bone marrow involvement in systemic mastocytosis patients having 1) up to 40% bone marrow infiltration by mast cells and/or 2) mediator-release symptoms which are not controlled by tolerated doses of standard "non-cytotoxic" medications regardless of the percentage bone marrow involvement by mastocytosis. The dose of Tamoxifen will be 40 mg/day and the duration of treatment will be for one year. Patients currently taking interferon alfa, imatinib mesylate, or cladribine will be excluded until these medications have been stopped.

Study identification

NCT ID: NCT01334996
Recruitment status: Completed
Study type: Observational
Phase: Not listed
Lead sponsor: Mayo Clinic; Other
Enrollment: 1 participant

Conditions and interventions

Conditions

Systemic Mastocytosis

Interventions

Not listed

Eligibility (public fields only)

Age range: 21 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 2005 (Type not available)
Primary completion: Aug 28, 2019 (Actual)
Completion: Aug 28, 2019 (Actual)
Last update posted: Apr 10, 2020

2005 – 2019

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Mayo Clinic	Rochester	Minnesota	55901	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01334996, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 10, 2020 · Synced Nov 15, 2026