A Study of Bevacizumab in Combination With Standard of Care Treatment in Participants With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC)
Public ClinicalTrials.gov record NCT01351415. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label, Randomized, Phase IIIb Trial Evaluating the Efficacy and Safety of Standard of Care +/- Continuous Bevacizumab Treatment Beyond Progression of Disease (PD) in Patients With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC) After First Line Treatment With Bevacizumab Plus a Platinum Doublet-containing Chemotherapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This open-label, randomized, multicenter study will evaluate the efficacy and safety of bevacizumab (Avastin) in combination with standard of care (SOC) treatment in participants with advanced non-squamous NSCLC. Participants will be enrolled at documentation of progression of disease (PD) after 4-6 cycles of first-line treatment with bevacizumab plus a platinum doublet-containing therapy and a minimum of two cycles of bevacizumab maintenance treatment prior to PD. Participants will be randomly assigned to one of two treatment arms to receive either bevacizumab plus SOC treatment or SOC treatment alone.
Study identification
- NCT ID
- NCT01351415
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 485 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 25, 2011 (Actual)
- Primary completion
- Jun 25, 2016 (Actual)
- Completion
- Jun 25, 2016 (Actual)
- Last update posted
- Sep 18, 2017
2011 – 2016
United States locations
- U.S. sites
- 68
- U.S. states
- 31
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| USA Mitchell Cancer Institute | Mobile | Alabama | 36688 | — |
| Palo Verde Hema/Onc | Glendale | Arizona | 85304 | — |
| Arizona Center for Cancer Care | Glendale | Arizona | 85306 | — |
| Clopton Clinic | Jonesboro | Arkansas | 72401 | — |
| East Valley Hematology ; Oncology Medical Group | Burbank | California | 91505 | — |
| California Cancer Associates for Research & Excellence, Inc. | Encinitas | California | 92008 | — |
| Scripps Clinic; Hematology & Oncology | La Jolla | California | 92037-1027 | — |
| Sutter Cancer Center | Sacramento | California | 95816 | — |
| Coastal Integrative Cancer Care | San Luis Obispo | California | 93401 | — |
| Innovative Clinical Research Institute | Whittier | California | 90603 | — |
| The Hospital of Central CT | New Britain | Connecticut | 06050 | — |
| Eastern Ct Hema/Onco Assoc; Dept of Oncology | Norwich | Connecticut | 06360 | — |
| Lynn Cancer Institute - West | Boca Raton | Florida | 33428 | — |
| Baptist - MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy) | Jacksonville | Florida | 32256 | — |
| Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| Cancer Care Centers of Brevard | Rockledge | Florida | 32955 | — |
| Emory Univ Winship Cancer Inst | Atlanta | Georgia | 30322 | — |
| Summit Cancer Care PC | Savannah | Georgia | 31405 | — |
| Kootenai Cancer Center | Post Falls | Idaho | 83854 | — |
| Alexian Brothers Neurosci Inst | Elk Grove Village | Illinois | 60007 | — |
| Oncology-Evanston Nthwest Healthcare Kellogg Cancer Care Ctr | Evanston | Illinois | 60201 | — |
| Joliet Oncology Hematology Associates, Ltd. | Joliet | Illinois | 60435 | — |
| Cancer Care & Hematology; Specialists of Chicagoland | Niles | Illinois | 60714 | — |
| W. Suburban Ctr for Cncer Care | River Forest | Illinois | 60305 | — |
| St. Francis Medical Group | Indianapolis | Indiana | 46237 | — |
| Oncology Hematology Associates of Southwest Indiana | Newburgh | Indiana | 47630 | — |
| McFarland Clinic | Ames | Iowa | 50010 | — |
| Cancer Center of Kansas | Wichita | Kansas | 67214-3728 | — |
| University of Kentucky Medical Center | Lexington | Kentucky | 40536 | — |
| Jewish Cancer Care | Louisville | Kentucky | 40245 | — |
| Hematology/Oncology Clinic, LLP | Baton Rouge | Louisiana | 70809 | — |
| Louisiana Oncology Associates | Lafayette | Louisiana | 70508 | — |
| New England Cancer Specialists | Scarborough | Maine | 04074 | — |
| York Hospital | York Village | Maine | 03909 | — |
| Anne Arundel Health System Research Instit-Annapolis Oncology Ctr | Annapolis | Maryland | 21401 | — |
| Tufts Medical Center; Neely Cancer Center | Boston | Massachusetts | 02111 | — |
| Ann Arbor Hematology Oncology | Ann Arbor | Michigan | 48106 | — |
| Henry Ford Hospital; Hematology Oncology | Detroit | Michigan | 48202 | — |
| Cancer & Hematology Center of West Michigan | Grand Rapids | Michigan | 49546 | — |
| Metro-Minnesota CCOP | Saint Louis Park | Minnesota | 55416 | — |
| St Joseph Oncology | Saint Joseph | Missouri | 64507 | — |
| Heartland CCOP/Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Stony Brook Univ Cancer Ctr; Medical Oncology Clinic | Stony Brook | New York | 11794-9447 | — |
| Carolina Oncology Specialists, PA - Hickory | Hickory | North Carolina | 28602 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Mid Ohio Onc Hematology Inc | Columbus | Ohio | 43219 | — |
| Dayton Clinical Oncology Prog | Dayton | Ohio | 45420 | — |
| Signal Point Clinical; Research Center, LLC | Middletown | Ohio | 45042 | — |
| Toledo Hospital; CCOP Toledo | Toledo | Ohio | 43617 | — |
| Bay Area Hospital | Coos Bay | Oregon | 97420 | — |
| St. Lukes Hospital and Health Network | Bethlehem | Pennsylvania | 18015 | — |
| Hematology & Oncology Assoc; North Eastern Pennsylvania | Dunmore | Pennsylvania | 18512 | — |
| St. Mary Medical Center | Langhorne | Pennsylvania | 19047 | — |
| University of Pennsylvania; Radiation Oncology | Philadelphia | Pennsylvania | 19104 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Lankenau Hospital | Wynnewood | Pennsylvania | 19096 | — |
| Memorial Hospital of Rhode Island | Pawtucket | Rhode Island | 02860 | — |
| West Clinic | Germantown | Tennessee | 38138 | — |
| University of Tennessee Medical Center Cancer Institute | Knoxville | Tennessee | 37920 | — |
| Unv of TX SW Med Cntr; Hematology/Onc | Dallas | Texas | 75390-9015 | — |
| Delta Hematology/ Oncology Associates | Portsmouth | Virginia | 23704 | — |
| Blue Ridge Cancer Care - Roanoke | Roanoke | Virginia | 24014 | — |
| Medical Oncology Associates | Spokane | Washington | 99208 | — |
| Fox Valley Hema and Onc SC | Appleton | Wisconsin | 54915 | — |
| Gundersen Lutheran | La Crosse | Wisconsin | 54601 | — |
| UNI OF WISCONSIN SCHOOL OF MEDICINE; GI Oncology Research Group, Paul P Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 111 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01351415, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 18, 2017 · Synced Oct 30, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01351415 live on ClinicalTrials.gov.