Study of Bevacizumab + mFOLFOX6 Versus Bevacizumab + FOLFIRI With Biomarker Stratification in Participants With Previously Untreated Metastatic Colorectal Cancer (mCRC)

ClinicalTrials.gov ID: NCT01374425

Public ClinicalTrials.gov record NCT01374425. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 3, 2026, 5:21 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

MAVERICC (Marker Evaluation for Avastin Research in CRC): A Randomized Phase II Study of Bevacizumab+mFOLFOX6 Vs. Bevacizumab+FOLFIRI With Biomarker Stratification in Patients With Previously Untreated Metastatic Colorectal Cancer

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This will be a randomized, open-label, multicenter, Phase II study with primary objectives to assess whether expression of select chemotherapy markers is associated with progression-free survival (PFS) in participants treated with bevacizumab plus leucovorin, 5-fluorouracil, and oxaliplatin (mFOLFOX6) or bevacizumab plus leucovorin, 5-fluorouracil, and irinotecan (FOLFIRI). The study population will consist of participants with first-line mCRC.

Study identification

NCT ID: NCT01374425
Recruitment status: Completed
Study type: Interventional
Phase: Phase 2
Lead sponsor: Genentech, Inc.; Industry
Enrollment: 376 participants

Conditions and interventions

Conditions

Colorectal Cancer

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 31, 2011
Primary completion: Apr 30, 2015
Completion: Jun 30, 2015
Last update posted: Aug 10, 2016

2011 – 2015

United States locations

U.S. sites: 65
U.S. states: 25
U.S. cities: 62

Facility	City	State	ZIP	Site status
Not listed	Birmingham	Alabama	35294	—
Not listed	Little Rock	Arkansas	72205-7199	—
Not listed	Bellflower	California	90706	—
Not listed	Duarte	California	91010	—
Not listed	Fountain Valley	California	92708	—
Not listed	Fresno	California	93720	—
Not listed	Hayward	California	94545	—
Not listed	Los Angeles	California	90033	—
Not listed	Oakland	California	94611	—
Not listed	Pleasant Hill	California	94523	—
Not listed	Roseville	California	95661	—
Not listed	Sacramento	California	95817	—
Not listed	Sacramento	California	95825	—
Not listed	San Francisco	California	94115	—
Not listed	San Jose	California	95119	—
Not listed	Santa Clara	California	95051	—
Not listed	South San Francisco	California	94080	—
Not listed	Vallejo	California	94589	—
Not listed	Walnut Creek	California	94596	—
Not listed	Denver	Colorado	80218	—
Not listed	Stamford	Connecticut	06902	—
Not listed	Trumbull	Connecticut	06611	—
Not listed	Hollywood	Florida	33021	—
Not listed	Jacksonville	Florida	32256	—
Not listed	Miami	Florida	33136	—
Not listed	Port Saint Lucie	Florida	34952	—
Not listed	Boise	Idaho	83712	—
Not listed	Joliet	Illinois	60435	—
Not listed	Maywood	Illinois	60153	—
Not listed	Peoria	Illinois	61615	—
Not listed	Goshen	Indiana	46526	—
Not listed	Indianapolis	Indiana	46237	—
Not listed	Terre Haute	Indiana	47802	—
Not listed	Fairway	Kansas	66205	—
Not listed	Elizabethtown	Kentucky	42791	—
Not listed	Scarborough	Maine	04074	—
Not listed	Burlington	Massachusetts	01805	—
Not listed	Billings	Montana	59102	—
Not listed	Lincoln	Nebraska	68506	—
Not listed	Cherry Hill	New Jersey	08003	—
Not listed	Manasquan	New Jersey	08736	—
Not listed	Albuquerque	New Mexico	87106	—
Not listed	Albuquerque	New Mexico	87110	—
Not listed	Albuquerque	New Mexico	87131-5636	—
Not listed	Farmington	New Mexico	87401	—
Not listed	Las Cruces	New Mexico	88011	—
Not listed	Santa Fe	New Mexico	87505	—
Not listed	Rochester	New York	14642	—
Not listed	Durham	North Carolina	27710	—
Not listed	Greensboro	North Carolina	27403	—
Not listed	High Point	North Carolina	27262	—
Not listed	Washington	North Carolina	27889	—
Not listed	Winston-Salem	North Carolina	27103	—
Not listed	Columbus	Ohio	43219	—
Not listed	Toledo	Ohio	43623	—
Not listed	Oklahoma City	Oklahoma	73142	—
Not listed	Dunmore	Pennsylvania	18512	—
Not listed	Media	Pennsylvania	19063	—
Not listed	Philadelphia	Pennsylvania	19107	—
Not listed	Pittsburgh	Pennsylvania	15212	—
Not listed	Charleston	South Carolina	29414	—
Not listed	Corpus Christi	Texas	78404	—
Not listed	Houston	Texas	77090	—
Not listed	Madison	Wisconsin	53792	—
Not listed	Wauwatosa	Wisconsin	53226	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01374425, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 10, 2016 · Synced Sep 3, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT01374425 live on ClinicalTrials.gov.

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