LAPLACE-TIMI 57: Low-density Lipoprotein Cholesterol (LDL-C) Assessment With PCSK9 monoclonaL Antibody Inhibition Combined With Statin thErapy
Public ClinicalTrials.gov record NCT01380730. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
LAPLACE TIMI 57 - A Double-blind, Randomized, Placebo-controlled, Multicenter, Dose-ranging Study to Evaluate Tolerability and Efficacy of AMG 145 on LDL-C in Combination With HMG-CoA Reductase Inhibitors in Hypercholesterolemic Subjects
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To evaluate the effect of 12 weeks of subcutaneous (SC) evolocumab (AMG 145) administered every 2 weeks (Q2W) or every 4 weeks (Q4W), compared with placebo, on percent change from baseline in LDL-C when used in addition to a statin in adults with hypercholesterolemia.
Study identification
- NCT ID
- NCT01380730
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 631 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 1, 2011 (Actual)
- Primary completion
- Apr 5, 2012 (Actual)
- Completion
- Apr 5, 2012 (Actual)
- Last update posted
- Nov 15, 2022
2011 – 2012
United States locations
- U.S. sites
- 55
- U.S. states
- 25
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35294 | — |
| Research Site | Tucson | Arizona | 85710 | — |
| Research Site | Malvern | Arkansas | 72104 | — |
| Research Site | Anaheim | California | 92801 | — |
| Research Site | Carmichael | California | 95608 | — |
| Research Site | Newport Beach | California | 92663 | — |
| Research Site | Roseville | California | 95747 | — |
| Research Site | Westlake Village | California | 91361 | — |
| Research Site | Colorado Springs | Colorado | 80909 | — |
| Research Site | Littleton | Colorado | 80120 | — |
| Research Site | Daytona Beach | Florida | 32117 | — |
| Research Site | Green Cove Springs | Florida | 32043 | — |
| Research Site | Melbourne | Florida | 32901 | — |
| Research Site | Miami | Florida | 33143 | — |
| Research Site | Miami | Florida | 33173 | — |
| Research Site | Port Charlotte | Florida | 33952 | — |
| Research Site | Peoria | Illinois | 61614 | — |
| Research Site | Hammond | Indiana | 46320 | — |
| Research Site | Indianapolis | Indiana | 46237 | — |
| Research Site | Valparaiso | Indiana | 46383 | — |
| Research Site | Iowa City | Iowa | 52242 | — |
| Research Site | Lexington | Kentucky | 40536 | — |
| Research Site | Auburn | Maine | 04210 | — |
| Research Site | Bangor | Maine | 04401 | — |
| Research Site | Portland | Maine | 04101 | — |
| Research Site | Kalamazoo | Michigan | 49048 | — |
| Research Site | Marquette | Michigan | 49855 | — |
| Research Site | Ypsilanti | Michigan | 48197 | — |
| Research Site | Tupelo | Mississippi | 38801 | — |
| Research Site | Great Falls | Montana | 59405 | — |
| Research Site | Voorhees Township | New Jersey | 08043 | — |
| Research Site | Cortlandt Manor | New York | 10567 | — |
| Research Site | Williamsville | New York | 14221 | — |
| Research Site | Smithfield | North Carolina | 27577 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Canton | Ohio | 44708 | — |
| Research Site | Cincinnati | Ohio | 45212 | — |
| Research Site | Cincinnati | Ohio | 45219 | — |
| Research Site | Dayton | Ohio | 45414 | — |
| Research Site | Mansfield | Ohio | 44906 | — |
| Research Site | Marion | Ohio | 43302 | — |
| Research Site | Sandusky | Ohio | 44870 | — |
| Research Site | Camp Hill | Pennsylvania | 17011 | — |
| Research Site | Philadelphia | Pennsylvania | 19104 | — |
| Research Site | Pittsburgh | Pennsylvania | 15216 | — |
| Research Site | York | Pennsylvania | 17405 | — |
| Research Site | Florence | South Carolina | 29501 | — |
| Research Site | Spartanburg | South Carolina | 29302 | — |
| Research Site | Rapid City | South Dakota | 57701 | — |
| Research Site | Jackson | Tennessee | 38301 | — |
| Research Site | Jackson | Tennessee | 38305 | — |
| Research Site | Houston | Texas | 77002 | — |
| Research Site | Houston | Texas | 77074 | — |
| Research Site | Tacoma | Washington | 98405 | — |
| Research Site | Madison | Wisconsin | 53713 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01380730, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 15, 2022 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01380730 live on ClinicalTrials.gov.