The Effect of Losartan in Bicuspid Aortic Valve Patients
Public ClinicalTrials.gov record NCT01390181. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
The Effect of Losartan Treatment on Matrix Metalloproteinase Levels and Outcomes in Bicuspid Aortic Valve Patients
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The specific aims of this study are to: * Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements \>40mm. * Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent. * In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate
Study identification
- NCT ID
- NCT01390181
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 4 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 31, 2011
- Primary completion
- Dec 31, 2013
- Completion
- Dec 31, 2013
- Last update posted
- Apr 13, 2017
2011 – 2014
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Recently updated Bicuspid Aortic Valve trials
Other public records listing Bicuspid Aortic Valve. Sorted by last update posted; newest first. Not a recommendation.
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- NCT01026571: Identification of Genetic Causes of Bicuspid Aortic Valve Disease Active, not recruiting
- NCT03440697: Pathogenetic Basis of Aortopathy and Aortic Valve Disease Active, not recruiting
- NCT06817148: Bicuspid Aortic Valve Replacement: Evaluation of Transcatheter Versus Surgery-Pilot Trial Recruiting
- NCT01756222: Bicuspid Aortic Valve (BAV) Registry Recruiting
- NCT03836521: Bicuspid Aortic Valve Stenosis Transcatheter Aortic Valve Replacement Registry Recruiting
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01390181, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 13, 2017 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01390181 live on ClinicalTrials.gov.