Brief Rifapentine-Isoniazid Evaluation for TB Prevention (BRIEF TB)
Public ClinicalTrials.gov record NCT01404312. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Clinical Trial of Ultra-Short-Course Rifapentine/Isoniazid for the Prevention of Active Tuberculosis in HIV-Infected Individuals With Latent Tuberculosis Infection
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
HIV-infected people have an increased risk of developing active tuberculosis (TB). At the time the study was designed, the standard course of treatment for TB was 6 to 9 months of isoniazid (INH).This study compared the safety and effectiveness of a 4-week regimen of rifapentine (RPT) plus INH versus a standard 9-month regimen of INH in HIV-infected people who are at risk of developing active TB.
Study identification
- NCT ID
- NCT01404312
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,000 participants
Conditions and interventions
Conditions
Interventions
- Rifapentine (RPT) Drug
- Isoniazid (INH) Drug
- Pyridoxine (Vitamin B6) Dietary Supplement
Drug · Dietary Supplement
Eligibility (public fields only)
- Age range
- 13 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 23, 2012 (Actual)
- Primary completion
- Nov 14, 2017 (Actual)
- Completion
- Nov 14, 2017 (Actual)
- Last update posted
- Nov 4, 2021
2012 – 2017
United States locations
- U.S. sites
- 21
- U.S. states
- 11
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California, UC San Diego CRS- Mother-Child-Adolescent HIV Program | La Jolla | California | 92093-0672 | — |
| University of Southern California CRS | Los Angeles | California | 90033-1079 | — |
| UCSD Antiviral Research Center CRS | San Diego | California | 92103 | — |
| Ucsf Hiv/Aids Crs | San Francisco | California | 94110 | — |
| Harbor-UCLA CRS | Torrance | California | 90502 | — |
| University of Colorado Hospital CRS | Aurora | Colorado | 80045 | — |
| Denver Public Health CRS | Denver | Colorado | 80204 | — |
| The University of Miami AIDS Clinical Research Unit (ACRU) CRS | Miami | Florida | 33136 | — |
| Northwestern University CRS | Chicago | Illinois | 60611 | — |
| Boston Medical Center CRS | Boston | Massachusetts | 02118 | — |
| Henry Ford Hosp. CRS | Detroit | Michigan | 48202 | — |
| Cooper Univ. Hosp. CRS | Camden | New Jersey | 08103 | — |
| New Jersey Medical School Clinical Research Center CRS | Newark | New Jersey | 07103 | — |
| Nyu Ny Nichd Crs | New York | New York | 10016 | — |
| Columbia P&S CRS | New York | New York | 10032-3732 | — |
| Bronx-Lebanon Hospital Center NICHD CRS | The Bronx | New York | 10457 | — |
| Chapel Hill CRS | Chapel Hill | North Carolina | 27599 | — |
| Duke University Medical Center CRS | Durham | North Carolina | 27710 | — |
| Trinity Health and Wellness Center CRS | Dallas | Texas | 75208 | — |
| Houston AIDS Research Team CRS | Houston | Texas | 77030 | — |
| University of Washington AIDS CRS | Seattle | Washington | 98104-9929 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01404312, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 4, 2021 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01404312 live on ClinicalTrials.gov.