Drug-drug Interaction Study With Metformin and Imatinib

ClinicalTrials.gov ID: NCT01404715

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Official title

Pharmacokinetic Interaction Between Metformin and Imatinib in Healthy Volunteers.

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will address the following question: Does imatinib influence the pharmacokinetics of metformin in healthy volunteers? Recent studies in the Giacomini laboratory have indicated that imatinib may block metformin elimination from the kidney by inhibiting organic cation transporter efflux of metformin. 1. The investigators hypothesize that the addition of imatinib to metformin therapy will reduce the renal clearance (CLR) of metformin leading to increased plasma concentrations and risk for toxicities 2. Knowledge of the pharmacokinetic interaction profile of metformin with organic cation transporter inhibitors, such as imatinib, is important to help develop safer more effective drug therapy with reduced side effects.

Study identification

NCT ID: NCT01404715
Recruitment status: Completed
Study type: Interventional
Phase: Phase 1
Lead sponsor: University of California, San Francisco; Other
Enrollment: 11 participants

Conditions and interventions

Conditions

Healthy

Interventions

Metformin Drug
Imatinib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 45 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 2011 (Type not available)
Primary completion: Mar 2013 (Actual)
Completion: Mar 2013 (Actual)
Last update posted: Apr 10, 2014

2011 – 2013

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Ucsf Ctsi Crc	San Francisco	California	94143	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01404715, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 10, 2014 · Synced Nov 13, 2026