ClinicalTrials.gov record
SYMPLICITY HTN-3 Renal Denervation in Patients With Uncontrolled Hypertension
ClinicalTrials.gov ID: NCT01418261
Public ClinicalTrials.gov record NCT01418261. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Renal Denervation in Patients With Uncontrolled Hypertension (SYMPLICITY HTN-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The Symplicity HTN-3 study is a, multi-center, prospective, single-blind, randomized, controlled study of the safety and effectiveness of renal denervation in subjects with uncontrolled hypertension. Bilateral renal denervation will be performed using the Symplicity Catheter - a percutaneous system that delivers radiofrequency (RF)energy through the luminal surface of the renal artery.
Study identification
- NCT ID
- NCT01418261
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 535 participants
Conditions and interventions
Conditions
Interventions
- Renal denervation (Symplicity Catheter System) Device
- Renal angiogram Diagnostic Test
Device · Diagnostic Test
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2011 (Type not available)
- Primary completion
- Dec 2013 (Actual)
- Completion
- Feb 17, 2017 (Actual)
- Last update posted
- Apr 26, 2017
2011 – 2017
United States locations
- U.S. sites
- 79
- U.S. states
- 28
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardiology, PC | Birmingham | Alabama | 35211 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Scripps Clinic/Scripps Green Hospital | La Jolla | California | 92037 | — |
| Kaiser Permanente - Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| St. Joseph Hospital | Orange | California | 92868 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| Stanford University | Stanford | California | 94305 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Howard University Hospital | Washington D.C. | District of Columbia | 20060 | — |
| Shands / University of Florida | Gainesville | Florida | 32610 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| University Of Miami | Miami | Florida | 33136 | — |
| Baptist Cardiac &Vascular Institute, Baptist Health Systems | Miami | Florida | 33176 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Piedmont Heart Institute | Atlanta | Georgia | 30309 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Midwest Heart Foundation | Oakbrook Terrace | Illinois | 60181 | — |
| Prairie Heart Institute | Springfield | Illinois | 62701 | — |
| Iowa Heart Center Research | Des Moines | Iowa | 50266 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| University of Maryland, Baltimore | Baltimore | Maryland | 21201 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| VA Boston Healthcare System | Boston | Massachusetts | 02132 | — |
| Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| UMass Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Harper University Hospital - Detroit Medical Center | Detroit | Michigan | 48201 | — |
| St Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| Providence Hospital | Southfield | Michigan | 48075 | — |
| Michigan Heart, St. Joseph Mercy Health System | Ypsilanti | Michigan | 48197 | — |
| Abbott Northwestern/Minneapolis Heart Institute Foundation | Minneapolis | Minnesota | 55407 | — |
| Saint Mary's Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Hattiesburg Clinic, P.A | Hattiesburg | Mississippi | 39401 | — |
| Saint Luke's Hospital of Kansas City/Mid America Heart Institute | Kansas City | Missouri | 64111 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Deborah Heart & Lung Center | Browns Mills | New Jersey | 08015 | — |
| Morristown Medical Center | Morristown | New Jersey | 07962 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07753 | — |
| SUNY Downstate Medical Center | Brooklyn | New York | 11203 | — |
| New York University Medical Center | New York | New York | 10015 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Mount Sinai Medical Center-Manhattan | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| St. Francis Hospital | Roslyn | New York | 11576 | — |
| Stony Brook University Hospital and Medical Center | Stony Brook | New York | 11794 | — |
| University of North Carolina Heart and Vascular | Chapel Hill | North Carolina | 27599 | — |
| Carolinas Healthcare (SHVI)-Clinical Research | Charlotte | North Carolina | 28203 | — |
| Duke University Health System | Durham | North Carolina | 27710 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| The Lindner Center for Research & Education at The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| The MetroHealth System | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| The Ohio State University | Columbus | Ohio | 43210 | — |
| OhioHealth Research Institute | Columbus | Ohio | 43214-3907 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17604 | — |
| Thomas Jefferson University Hospitals, Inc | Philadelphia | Pennsylvania | 19107 | — |
| University of Pennsylvania Health System | Philadelphia | Pennsylvania | 19130 | — |
| UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Vascular Disease Research Center at Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Stern Cardiovascular Foundation, Inc. | Memphis | Tennessee | 38138 | — |
| Vanderbilt Medical Center | Nashville | Tennessee | 37232-7235 | — |
| Austin Heart PLLC / Heart Hospital of Austin | Austin | Texas | 78756 | — |
| VA North Texas Health Care System | Dallas | Texas | 75216 | — |
| Soltero Cardiovascular Research Center - Baylor Jack and Jane Hamilton Heart & Vascular Hospital | Dallas | Texas | 75226 | — |
| The Methodist Hospital | Houston | Texas | 77030 | — |
| The Heart Hospital Baylor Plano | Plano | Texas | 75093 | — |
| Fletcher Allen Health Care | Burlington | Vermont | 05401 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01418261, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 26, 2017 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01418261 live on ClinicalTrials.gov.