Blood Pressure in Dialysis Patients
Public ClinicalTrials.gov record NCT01421771. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Blood Pressure in Dialysis Patients (BID Study)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Hypertension is a major cause of cardiovascular (CV) morbidity and mortality. Although studies in the general population have demonstrated a continuous reduction in CV risk with each mmHg drop in systolic blood pressure (SBP), multiple observational studies conducted in hemodialysis (HD) patients have demonstrated that patients with mild to moderate hypertension may have decreased mortality compared to those with normal blood pressure (BP). The investigators recently reported that among HD patients, those with routine pre-dialysis BP values that met the Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines (\<140/90 mm Hg) had increased mortality compared to patients with mild to moderate hypertension. However, these observational studies included untreated patients in whom low or normal BP may reflect significant cardiac disease or other comorbid conditions. In the setting of reduced vascular compliance and impaired autoregulation, aggressive BP lowering may decrease coronary or cerebral perfusion. Thus, it is unclear if aggressive BP lowering will be harmful or beneficial. A well-designed randomized control trial (RCT) is needed to answer this important question. Prior to conducting a full-scale RCT it is prudent to conduct a pilot study to assess feasibility and inform the design of the former. The investigators propose to conduct a pilot RCT in a prevalent cohort of HD patients to assess the safety and feasibility of treating patients to a low (110-140 mmHg)and standard (155-165) mm Hg pre-dialysis BP target.
Study identification
- NCT ID
- NCT01421771
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 126 participants
Conditions and interventions
Interventions
- Antihypertensive Agents Drug
- Dry weight Challenge Other
- Extend dialysis treatment time and re-challenge estimated dry weight Dietary Supplement
Drug · Other · Dietary Supplement
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 30, 2011
- Primary completion
- Dec 31, 2015
- Completion
- May 31, 2016
- Last update posted
- Nov 29, 2023
2011 – 2016
United States locations
- U.S. sites
- 21
- U.S. states
- 5
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Dialysis Clinic Inc - Boston | Boston | Massachusetts | 02111 | — |
| DaVita Boston | Boston | Massachusetts | 02118 | — |
| Dialysis Clinic Inc - Walden Pond Clinic | Concord | Massachusetts | 01742 | — |
| Dialysis Clinic Inc - Faulkner | Jamaica Plain | Massachusetts | 02130 | — |
| Dialysis Clinic Inc - Somerville | Somerville | Massachusetts | 02145 | — |
| Dialysis Clinic Inc - Albuquerque | Albuquerque | New Mexico | 87102 | — |
| Dialysis Clinic Inc - Albuquerque South | Albuquerque | New Mexico | 87105 | — |
| Dialysis Clinic Inc - Albuquerque East | Albuquerque | New Mexico | 87110 | — |
| Dialysis Clinic Inc - Grants | Grants | New Mexico | 87020 | — |
| Dialysis Clinic Inc - Rio Rancho | Rio Rancho | New Mexico | 87124 | — |
| Centers for Dialysis Care East | Cleveland | Ohio | 44106 | — |
| Centers for Dialysis Care - Shaker Heights | Cleveland | Ohio | 44122 | — |
| Dialysis Clinic Inc - Oakland | Pittsburgh | Pennsylvania | 15213 | — |
| Dialysis Clinic Inc - Banksville | Pittsburgh | Pennsylvania | 15216 | — |
| Dialysis Clinic Inc - Point Breeze | Pittsburgh | Pennsylvania | 15221 | — |
| Dialysis Clinic Inc - North Hills | Pittsburgh | Pennsylvania | 15237 | — |
| Dialysis Clinic Inc - Magnolia Court | Charleston | South Carolina | 29403 | — |
| Dialysis Clinic Inc - West Ashley | Charleston | South Carolina | 29407 | — |
| Dialysis Clinic Inc - James Island | Charleston | South Carolina | 29412 | — |
| Dialysis Clinic Inc - East Cooper | Mt. Pleasant | South Carolina | 29464 | — |
| Dialysis Clinic Inc - Azalea Place | North Charleston | South Carolina | 29406 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01421771, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 29, 2023 · Synced Sep 12, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01421771 live on ClinicalTrials.gov.