PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME)
Public ClinicalTrials.gov record NCT01445899. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label Dose Escalation Study of PF-04523655 (Stratum I) Combined With a Prospective, Randomized, Double-Masked, Multi-Center, Controlled Study (Stratum II) Evaluating the Efficacy and Safety of PF-04523655 Alone and in Combination With Ranibizumab Versus Ranibizumab Alone in Diabetic Macular Edema (MATISSE STUDY)
Study identification
- NCT ID
- NCT01445899
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Quark Pharmaceuticals
- Industry
- Enrollment
- 258 participants
Conditions and interventions
Interventions
- PF-04523655 (Stratum I) Drug
- ranibizumab Drug
- PF-04523655 (Stratum II) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 31, 2012
- Primary completion
- Oct 31, 2013
- Completion
- Oct 31, 2013
- Last update posted
- Feb 22, 2015
2012 – 2013
United States locations
- U.S. sites
- 20
- U.S. states
- 12
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina Consultants of Arizona | Phoenix | Arizona | 85014 | — |
| Retina Institute of California | Arcadia | California | 91007 | — |
| Retina-Vitreous Associates | Beverly Hills | California | 90211 | — |
| Retina Diagnostic Center | Campbell | California | 95008 | — |
| Retinal Consultants Medical Group, Inc. | Sacramento | California | 95819 | — |
| Orange County Reina Medical Group | Santa Ana | California | 92705 | — |
| MedEye Associates | Miami | Florida | 33143 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| Thomas A. Cuilla, MD, PC at Midwest Eye Institute | Indianapolis | Indiana | 46290 | — |
| Eyesight Ophthalmic Services, PA | Portsmouth | New Hampshire | 03801 | — |
| Retina Vitreous Center | Toms River | New Jersey | 08755 | — |
| Southeast Clinical Research Associates, LLC | Charlotte | North Carolina | 28210 | — |
| Black Hills Regioinal Eye Institute | Rapid City | South Dakota | 57701 | — |
| Tennessee Retina, PC | Nashville | Tennessee | 37203 | — |
| Retina Research Center | Austin | Texas | 78705 | — |
| Retinal Consultants of Houston | Houston | Texas | 77030 | — |
| Valley Retina Institute | McAllen | Texas | 78503 | — |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78204 | — |
| Retinal Institute of Virginia | Richmond | Virginia | 23235 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 31 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01445899, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 22, 2015 · Synced Jun 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01445899 live on ClinicalTrials.gov.