Inhaled Nitric Oxide/INOpulse DS for Pulmonary Arterial Hypertension (PAH)
Public ClinicalTrials.gov record NCT01457781. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Placebo Controlled, Double-Blind, Randomized, Clinical Study to Determine Safety, Tolerability and Efficacy of Pulsed, Inhaled Nitric Oxide (iNO) Versus Placebo as Add-On Therapy in Symptomatic Subjects With Pulmonary Arterial Hypertension (PAH)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2, Placebo Controlled, Double-Blind, Randomized, Clinical Study to Determine Safety, Tolerability and Efficacy of Pulsed, Inhaled Nitric Oxide (iNO) Versus Placebo as Add-on Therapy in Symptomatic Subjects with Pulmonary Arterial Hypertension (PAH).
Study identification
- NCT ID
- NCT01457781
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 80 participants
Conditions and interventions
Interventions
- Inhaled Nitric Oxide 0.025 mg/kg IBW/hr delivered via INOpulse DS Device Combination Product
- Placebo delivered via INOpulse DS Device Combination Product
- Inhaled nitric oxide 0.075 mg/kg IBW/hr delivered via INOpulse DS Device Combination Product
Combination Product
Eligibility (public fields only)
- Age range
- 16 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2012 (Type not available)
- Primary completion
- Oct 2014 (Actual)
- Completion
- Jul 2016 (Actual)
- Last update posted
- Feb 27, 2023
2012 – 2016
United States locations
- U.S. sites
- 47
- U.S. states
- 29
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294-0006 | — |
| Arizona Pulmonary Specialists | Phoenix | Arizona | 85012 | — |
| Allianz Research Institute, Inc. | Fountain Valley | California | 92708 | — |
| University of California, San Francisco-Fresno | Fresno | California | 93721 | — |
| West Los Angeles VA Healthcare Center | Los Angeles | California | 90073 | — |
| David Geffen School of Medicine at UCLA | Los Angeles | California | 90095 | — |
| Los Angeles Biomedical Research Institute at Harbor-UCLA Med Ctr | Torrance | California | 90509 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| South Denver Cardiology Associates P.C. | Littleton | Colorado | 80120 | — |
| Christiana Care Health System | Newark | Delaware | 19713 | — |
| University of Florida College of Medicine | Jacksonville | Florida | 32209 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Emory University Hospital-Emory Clinic | Atlanta | Georgia | 30322 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky Gill Heart | Lexington | Kentucky | 40536 | — |
| Kentuckiana Pulmonary Associates | Louisville | Kentucky | 40202 | — |
| LSUHSC-New Orleans | New Orleans | Louisiana | 70112 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Boston University Medical Center/Boston University School of Medicine | Boston | Massachusetts | 02118-2526 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| University of Minnesota, Cardiovascular Division | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| University of Medicine and Dentistry of NJ | Newark | New Jersey | 07103 | — |
| Barnabas Health Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| Beth Israel Medical Center | New York | New York | 10003 | — |
| Weill Cornell Medical Center | New York | New York | 10021 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| UC Health/University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University Martha Morehouse Medical Pavillion | Columbus | Ohio | 43221 | — |
| South Oklahoma Heart Research LLC | Oklahoma City | Oklahoma | 73135 | — |
| Legacy Medical Group - Pulmonary Clinic | Portland | Oregon | 97210 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Allegheny Singer Research Institute/Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Sioux Falls Cardiovascular PC | Sioux Falls | South Dakota | 57108 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84157 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01457781, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 27, 2023 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01457781 live on ClinicalTrials.gov.