Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery
Public ClinicalTrials.gov record NCT01459679. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Multi-Center, Randomized, Controlled Evaluation of the Safety & Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objectives of this study are to evaluate and compare the safety and efficacy of three treatment regimens for corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System in impeding the progression of, and/or reducing maximum corneal curvature.
Study identification
- NCT ID
- NCT01459679
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,721 participants
Conditions and interventions
Conditions
Interventions
- KXL System (15 mW/cm2) Device
- KXL System (30 mW/cm2) Device
- KXL System (45 mW/cm2) Device
- riboflavin ophthalmic solution Drug
Device · Drug
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 2012 (Type not available)
- Primary completion
- Jan 2016 (Actual)
- Completion
- Aug 2016 (Actual)
- Last update posted
- Jul 5, 2018
2012 – 2016
United States locations
- U.S. sites
- 82
- U.S. states
- 37
- U.S. cities
- 74
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| John Parker | Birmingham | Alabama | 35233 | — |
| Barnet Dulaney Perkins Eye Center | Phoenix | Arizona | 85016 | — |
| Advanced Vision Care | Los Angeles | California | 90067 | — |
| Stanford University School of Medicine | Palo Alto | California | 94303 | — |
| Grutzmacher, Lewis and Sierra | Sacramento | California | 95815 | — |
| Center for Sight | Sacramento | California | 95816 | — |
| Newman Lasik Centers | Sacramento | California | 95821 | — |
| Batra Vision Medical Group | San Leandro | California | 94578 | — |
| Delta Eye Medical Group | Stockton | California | 95207 | — |
| Kaiser Permanente - Kaiser Network Patients in Northern California Only | Walnut Creek | California | 94598 | — |
| Mile High Corneal Specialists, PC | Denver | Colorado | 80210 | — |
| Manchester Ophthalmology | Manchester | Connecticut | 06040 | — |
| Eye Physicians and Surgeons, PC | Milford | Connecticut | 06460 | — |
| TLC of Miami The Laser Center of Coral Gables | Coral Gables | Florida | 33134 | — |
| Delray Eye Associates, PA | Delray Beach | Florida | 33484 | — |
| Braverman Eye Center | Hallandale | Florida | 33009 | — |
| The Eye Institute of West Florida | Largo | Florida | 33770 | — |
| Herschel Lasik | Orlando | Florida | 32803 | — |
| LCA-Vision Inc | Tampa | Florida | 33607 | — |
| Quantum Vision Centers | Belleville | Illinois | 62226 | — |
| University of Iowa Hospitals and Clinics | Coralville | Iowa | 52241 | — |
| Kansas LasikPlus, P.A. | Leawood | Kansas | 66211 | — |
| Grene Vision Group | Wichita | Kansas | 67208 | — |
| LaskiPlus Vision Center | Louisville | Kentucky | 40207 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70115 | — |
| Eyecare Medical Group | Portland | Maine | 04102 | — |
| GBMC Dept. of Opthalmology/Mid-Atlantic Cornea Consultants | Baltimore | Maryland | 21204 | — |
| Solomon Eye Physicians and Surgeons | Bowie | Maryland | 20716 | — |
| Eye Doctors of Washington | Chevy Chase | Maryland | 20815 | — |
| Boston Eye Group | Brookline | Massachusetts | 02446 | — |
| Ophthalmic Consultants of Boston | Waltham | Massachusetts | 02451 | — |
| University of Michigan | Ann Arbor | Michigan | 48105 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Verdier Eye Center P.L.C. | Grand Rapids | Michigan | 49546 | — |
| Michigan Cornea Consultants | Southfield | Michigan | 48034 | — |
| Chu Vision Institute | Bloomington | Minnesota | 55420 | — |
| Eye Surgery and Laser Center | Madison | Mississippi | 39110 | — |
| Pepose Vision Institute/ Lifelong Vision Foundation | Chesterfield | Missouri | 63017 | — |
| Ophthamology Consultants LLC | St Louis | Missouri | 63131 | — |
| The Eye Clinic Surgicenter | Billings | Montana | 59102 | — |
| Eye Surgical Associates | Lincoln | Nebraska | 68506 | — |
| Kugler Vision, PC | Omaha | Nebraska | 68144 | — |
| Wellish Vision Institute | Las Vegas | Nevada | 89119 | — |
| Princeton Eye Group | Princeton | New Jersey | 08540 | — |
| Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | — |
| CNY Eye Care | De Witt | New York | 13214 | — |
| North Shore LIJ Health Systems | Great Neck | New York | 11021 | — |
| Ramapo Ophthalmology Associates, LLP | Pomona | New York | 10970 | — |
| Carolina Vision Center | Fayetteville | North Carolina | 28304 | — |
| Bagan Strinden Vision | Fargo | North Dakota | 58103 | — |
| Comprehensive Eye Care of Central Ohio | Westerville | Ohio | 43082 | — |
| Dean McGee Eye Institute | Oklahoma City | Oklahoma | 73104 | — |
| Devers Eye Institute | Portland | Oregon | 97210 | — |
| Casey Eye Institute/OHSU | Portland | Oregon | 97239 | — |
| Ophthalmic Partners of PA, P.C. | Bala-Cynwyd | Pennsylvania | 19004 | — |
| Schein Ernst Eye Associates | Harrisburg | Pennsylvania | 17110 | — |
| Scheie Eye Institute, University of Pennsylvania School of Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Corneal Associates, Wills Eye Institute | Philadelphia | Pennsylvania | 19107 | — |
| Northeastern Eye Institute | Scranton | Pennsylvania | 18503 | — |
| Bucci Laser Vision Institute | Wilkes-Barre | Pennsylvania | 18702 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Wright Vision Center | Rapid City | South Dakota | 57701 | — |
| Vance Thompson Vision | Sioux Falls | South Dakota | 57108 | — |
| Loden Vision Center | Goodlettsville | Tennessee | 37072 | — |
| Wang Vision Institute | Nashville | Tennessee | 37203 | — |
| Dell Laser Consultants | Austin | Texas | 78746 | — |
| Buena Vista Eyecare | El Paso | Texas | 79902 | — |
| Eye Consultants of Texas | Grapevine | Texas | 76051 | — |
| Berkeley Eye Center | Houston | Texas | 77027 | — |
| Slade and Baker Vision Center | Houston | Texas | 77027 | — |
| Focal Point Vision | San Antonio | Texas | 78229 | — |
| Hoopes Vision | Draper | Utah | 84020 | — |
| The Eye Institute of Utah | Salt Lake City | Utah | 84107 | — |
| University of Utah Dept. of Ophthalmology & Visual Sciences | Salt Lake City | Utah | 84132 | — |
| Silk Vision & Surgical Center | Annandale | Virginia | 22003 | — |
| Virginia Eye Consultants | Norfolk | Virginia | 23502 | — |
| Commonwealth Eye Associates | Richmond | Virginia | 23238 | — |
| Eye Care Center of Virginia | Richmond | Virginia | 23294 | — |
| Beach Eye Care | Virginia Beach | Virginia | 23454 | — |
| Evergreen Eye Center | Federal Way | Washington | 98003 | — |
| Gundersen Clinic, Ltd. | La Crosse | Wisconsin | 54601 | — |
| Dean Foundation for Health, Research and Education, Inc. | Madison | Wisconsin | 43715 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01459679, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 5, 2018 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01459679 live on ClinicalTrials.gov.