Selective 5-HT4 Receptor Agonist and Proton Pump Inhibitor (PPI) in Subjects With Gastroesophageal Reflux Disease (GERD)
Public ClinicalTrials.gov record NCT01472939. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Double-blind, Randomized, Placebo-controlled, Dose-finding Study to Evaluate Efficacy of a Selective 5-HT4 Receptor Agonist and Proton Pump Inhibitor (PPI) in Subjects With Gastroesophageal Reflux Disease (GERD) With Persistent Regurgitation With or Without Heartburn
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The aim of this study is to establish a dose-related effect of a selective 5-HT4 receptor agonist compared to placebo on residual symptoms (regurgitation with or without heartburn) in subjects with GERD who have persistent symptoms while on PPI therapy.
Study identification
- NCT ID
- NCT01472939
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 480 participants
Conditions and interventions
Conditions
Interventions
- SSP-002358 (0.1 mg) + PPI Drug
- SSP-002358 (0.5 mg) + PPI Drug
- SSP-002358 (2.0 mg) + PPI Drug
- Placebo + PPI Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 27, 2012 (Actual)
- Primary completion
- May 14, 2013 (Actual)
- Completion
- May 14, 2013 (Actual)
- Last update posted
- Jun 9, 2021
2012 – 2013
United States locations
- U.S. sites
- 62
- U.S. states
- 29
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| HOPE Research Institute | Phoenix | Arizona | 85050 | — |
| Genova Clinical Research | Tucson | Arizona | 85704 | — |
| Lynn Institute of the Ozarks | Little Rock | Arkansas | 72205 | — |
| Preferred Research Partners, Inc | Little Rock | Arkansas | 72211 | — |
| Arkansas Gastroenterology | North Little Rock | Arkansas | 72117 | — |
| Anaheim Clinical Trials | Anaheim | California | 92801-2417 | — |
| Southern California Research Institute Medical Group Inc | Los Angeles | California | 90045 | — |
| Medical Center for Clinical Research | San Diego | California | 92108 | — |
| Clinicos | Colorado Springs | Colorado | 80904 | — |
| Connecticut Gastroenterology Institute | Bristol | Connecticut | 06010 | — |
| Stamford Therapeutics Consortium | Stamford | Connecticut | 06905 | — |
| Medical Research Unlimited, LLC | Aventura | Florida | 33180 | — |
| Consultants for Clinical Research of South Florida | Boynton Beach | Florida | 33426 | — |
| PAB Clinical Research | Brandon | Florida | 33511 | — |
| Avail Clinical Research, LLC | DeLand | Florida | 32720 | — |
| S & W Clinical Research | Fort Lauderdale | Florida | 33306 | — |
| Medical Research Unlimited, LLC | Hialeah | Florida | 33012 | — |
| Jupiter Research | Jupiter | Florida | 33458 | — |
| Pines Clinical Research, Inc. | Pembroke Pines | Florida | 33028 | — |
| Radiant Research | Pinellas Park | Florida | 33781 | — |
| Accord Clinical Research, LLC | Port Orange | Florida | 32129 | — |
| Meridien Research | St. Petersburg | Florida | 33709 | — |
| Gastrointestinal Specialists of GA, PC | Marietta | Georgia | 30060 | — |
| Digestive Research Associates | Newnan | Georgia | 30263 | — |
| Rockford Gastroenterology Associates, Ltd | Rockford | Illinois | 61107 | — |
| Professional Research Network of Kansas, LLC | Wichita | Kansas | 67203 | — |
| Research Integrity | Owensboro | Kentucky | 42303 | — |
| Clinical Trials Management | Metairie | Louisiana | 70006 | — |
| Louisiana Research Center, LLC | Shreveport | Louisiana | 71103 | — |
| Meritus Medical Center | Hagerstown | Maryland | 21742 | — |
| Beacon Clinical Research | Brockton | Massachusetts | 02301 | — |
| Center for Digestive and Liver Diseases | Mexico | Missouri | 65265 | — |
| Clinical Research Group of Montana | Bozeman | Montana | 59718 | — |
| Meridian Clinical Research | Omaha | Nebraska | 68134 | — |
| Clinical Research Center of Nevada | Las Vegas | Nevada | 89104 | — |
| New Jersey Physicians, LLC | Clifton | New Jersey | 07012 | — |
| UNC Hospitals | Chapel Hill | North Carolina | 27599 | — |
| Carolinas Research Associates | Davidson | North Carolina | 28036 | — |
| Cumberland Research Associates | Fayetteville | North Carolina | 28314 | — |
| Vital Research, Inc. | Greensboro | North Carolina | 27408 | — |
| Carolinas Research Associates | Harrisburg | North Carolina | 28075 | — |
| Peters Medical Research | High Point | North Carolina | 27262 | — |
| Wake Research Associates | Raleigh | North Carolina | 27612 | — |
| Prestige Clinical Research | Franklin | Ohio | 45005 | — |
| Oklahoma Foundation for Digestive Research Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Family Medical Associates | Levittown | Pennsylvania | 19056 | — |
| Guthrie Clinic, Ltd. | Sayre | Pennsylvania | 18840 | — |
| Omega Medical Research | Warwick | Rhode Island | 02886 | — |
| Meridian Clinical Research | Dakota Dunes | South Dakota | 57049 | — |
| Clinsearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Radiant Research Dallas-North | Dallas | Texas | 75231 | — |
| GI Consultants, P.A. | Houston | Texas | 77034 | — |
| Pasadena Gastroenterology Assoc, dba Digestive Health Center | Pasadena | Texas | 77505 | — |
| Office Based Practitioner | San Antonio | Texas | 78229 | — |
| Advanced Research Institute | Clinton | Utah | 84015 | — |
| Advanced Research Institute | Logan | Utah | 84341 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| Advanced Research Institute | Sandy City | Utah | 84094 | — |
| New River Valley Research Institute | Christiansburg | Virginia | 24073 | — |
| Blue Ridge Medical Center | Lynchburg | Virginia | 24502 | — |
| Ramstad Medical Associates | Suffolk | Virginia | 23435 | — |
| Aurora Wilkinson Medical Clinic | Summit | Wisconsin | 53066 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01472939, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 9, 2021 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01472939 live on ClinicalTrials.gov.