A Study Combining mFOLFOX6 With Tivozanib or Bevacizumab in Patients With Metastatic Colorectal Cancer as First Line Therapy
Public ClinicalTrials.gov record NCT01478594. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Open Label, Multicenter, Randomized Trial Comparing Tivozanib in Combination With mFOLFOX6 to Bevacizumab in Combination With mFOLFOX6, In Stage IV Metastatic Colorectal Cancer (mCRC) Subjects
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this study is to compare the progression free survival (PFS), overall survival (OS), objective response rate (ORR), time to treatment failure (TTF), duration of response (DoR), quality of life, safety and tolerability of tivozanib in combination with mFOLFOX6 and bevacizumab in combination with mFOLFOX6.
Study identification
- NCT ID
- NCT01478594
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 265 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2011 (Type not available)
- Primary completion
- Sep 2013 (Actual)
- Completion
- Jan 2015 (Actual)
- Last update posted
- Jul 8, 2015
2011 – 2015
United States locations
- U.S. sites
- 27
- U.S. states
- 17
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Research Center | Gilbert | Arizona | 85234 | — |
| Genesis Cancer Center | Hot Springs | Arizona | 71913 | — |
| Arizona Clinical Research Center | Tucson | Arizona | 85715 | — |
| University of California San Diego-Morris Cancer Center | La Jolla | California | 92093 | — |
| UC Irvine Medical Center, Division of Hematology/Oncology | Orange | California | 92868 | — |
| Desert Hematology Oncology Medical Group, Inc. | Rancho Mirage | California | 92270 | — |
| Mountain Blue Cancer Care Center | Golden | Colorado | 80033 | — |
| University of Florida, Davis Cancer Center (VA) | Gainesville | Florida | 32610 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| University of Hawaii | Honolulu | Hawaii | 96813 | — |
| Kaiser Foundation Hospitals | Honolulu | Hawaii | 96819 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Illinios Cancer Care | Peoria | Illinois | 61615 | — |
| Investigative Clinical Research of Indiana, LLC | Indianapolis | Indiana | 46260 | — |
| Horizon Oncology Research, Inc. | Lafayette | Indiana | 47905 | — |
| Associates of Oncology Hematology, P.C. | Rockville | Maryland | 20850 | — |
| University of Michigan Health | Ann Arbor | Michigan | 48109 | — |
| NYU Cancer Institute | New York | New York | 10016 | — |
| Alamance Regional Medical Center | Burlington | North Carolina | 27215 | — |
| Tri Country Hematology / Oncology | Canton | Ohio | 44718 | — |
| Signal Point Clinical Research Center, LLC | Middletown | Ohio | 45042 | — |
| Cancer Care Associates | Tulsa | Oklahoma | 74136 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Oncology Hematology of Lehigh Valley | Bethlehem | Pennsylvania | 18015 | — |
| Northern Utah Associates | Ogden | Utah | 84403 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01478594, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 8, 2015 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01478594 live on ClinicalTrials.gov.