Prompt Panretinal Photocoagulation Versus Ranibizumab+Deferred Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
Public ClinicalTrials.gov record NCT01489189. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Prompt Panretinal Photocoagulation Versus Intravitreal Ranibizumab With Deferred Panretinal Photocoagulation for Proliferative Diabetic Retinopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the protocol is to determine if visual acuity outcomes at 2 years in eyes with proliferative diabetic retinopathy (PDR) that receive anti-vascular endothelial growth factor (anti-VEGF) therapy with deferred panretinal photocoagulation (PRP) are non-inferior to those in eyes that receive standard prompt PRP therapy. Secondary objectives include: * Comparing other visual function outcomes (including Humphrey visual field testing and study participant self-reports of visual function) in eyes receiving anti-VEGF with deferred PRP with those in eyes receiving prompt PRP. * Determining percent of eyes not requiring PRP when anti-VEGF is given in the absence of prompt PRP. * Comparing safety outcomes between treatment groups. * Comparing associated treatment and follow-up exam costs between treatment groups.
Study identification
- NCT ID
- NCT01489189
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 305 participants
Conditions and interventions
Conditions
Interventions
- Prompt Panretinal Photocoagulation Other
- 0.5-mg Ranibizumab Drug
- Deferred panretinal photocoagulation Other
Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2012 (Type not available)
- Primary completion
- Jan 2015 (Actual)
- Completion
- Feb 5, 2018 (Actual)
- Last update posted
- Oct 29, 2021
2012 – 2018
United States locations
- U.S. sites
- 48
- U.S. states
- 24
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Consultants of AZ | Phoenix | Arizona | 85014 | — |
| Loma Linda University Health Care, Dept. of Ophthalmology | Loma Linda | California | 92354 | — |
| Southern California Desert Retina Consultants, MC | Palm Springs | California | 92262 | — |
| California Retina Consultants | Santa Barbara | California | 93103 | — |
| Bay Area Retina Associates | Walnut Creek | California | 94598 | — |
| New England Retina Associates | Trumbull | Connecticut | 06611 | — |
| Retina Consultants of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Central Florida Retina Institute | Lakeland | Florida | 33805 | — |
| Ocala Eye Retina Consultants | Ocala | Florida | 34474 | — |
| Fort Lauderdale Eye Institute | Plantation | Florida | 33324 | — |
| Retina Associates of Sarasota | Venice | Florida | 34285 | — |
| Southeast Retina Center, P.C. | Augusta | Georgia | 30909 | — |
| North Shore University Health System | Glenview | Illinois | 60026 | — |
| Raj K. Maturi, M.D., P.C. | Indianapolis | Indiana | 46290 | — |
| John-Kenyon American Eye Institute | New Albany | Indiana | 47150 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Retina and Vitreous Associates of Kentucky | Lexington | Kentucky | 40509-1802 | — |
| Paducah Retinal Center | Paducah | Kentucky | 42001 | — |
| Elman Retina Group, P.A. | Baltimore | Maryland | 21237 | — |
| Vitreo-Retinal Associates, PC | Worcester | Massachusetts | 01605 | — |
| Retina Vitrous Center | Grand Blanc | Michigan | 48439 | — |
| Barnes Retina Institute | St Louis | Missouri | 63110 | — |
| Eye Surgical Associates | Lincoln | Nebraska | 38506 | — |
| The New York Eye and Ear Infirmary/Faculty Eye Practice | New York | New York | 10003 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Retina-Vitreous Surgeons of Central New York, PC | Syracuse | New York | 13224 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599-7040 | — |
| Charlotte Eye, Ear, Nose and Throat Assoc., PA | Charlotte | North Carolina | 28210 | — |
| Retina Associates of Cleveland, Inc. | Beachwood | Ohio | 44122 | — |
| Retina Northwest, PC | Portland | Oregon | 97210 | — |
| Casey Eye Institute | Portland | Oregon | 97239 | — |
| Penn State College of Medicine | Hershey | Pennsylvania | 17033 | — |
| Family Eye Group | Lancaster | Pennsylvania | 17601-2644 | — |
| Retina Vitrous Consultants | Pittsburgh | Pennsylvania | 15213 | — |
| Carolina Retina Center | Columbia | South Carolina | 29223 | — |
| Southeastern Retina Associates, PC | Kingsport | Tennessee | 37660 | — |
| Southeastern Retina Associates, P.C. | Knoxville | Tennessee | 37909 | — |
| Austin Retina Associates | Austin | Texas | 78705 | — |
| Retina Research Center | Austin | Texas | 78705 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Retina and Vitreous of Texas | Houston | Texas | 77025 | — |
| Baylor Eye Physicians and Surgeons | Houston | Texas | 77030 | — |
| Texas Retina Associates | Lubbock | Texas | 79424 | — |
| Valley Retina Institute | McAllen | Texas | 78503 | — |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78240 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Spokane Eye Clinic | Spokane | Washington | 99204 | — |
| Medical College of Wiconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01489189, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 29, 2021 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01489189 live on ClinicalTrials.gov.