Vitamin D Supplementation in Multiple Sclerosis
Public ClinicalTrials.gov record NCT01490502. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Controlled Trial of Vitamin D Supplementation in Multiple Sclerosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Low vitamin D levels have been shown to increase a person's risk of developing multiple sclerosis (MS), and patients with MS who have lower vitamin D levels are at increased risk of having attacks. However, it is not known if giving supplemental vitamin D to those with MS reduces the risk of attacks, and some research suggests that vitamin D could even be harmful to people with MS. In this clinical trial, patients with relapsing-remitting MS will receive high-dose or low-dose oral vitamin D in addition to an approved therapy for MS, glatiramer acetate. Patients will be evaluated for two years, and the effect of high-dose vitamin D supplementation on the rate of MS attacks and on the number of new lesions and change in brain volume on MRI will be determined. Establishing this association will have major implications for the treatment of individuals with MS throughout the world.
Study identification
- NCT ID
- NCT01490502
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 172 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 50 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2012 (Actual)
- Primary completion
- May 15, 2021 (Actual)
- Completion
- May 15, 2021 (Actual)
- Last update posted
- Sep 28, 2022
2012 – 2021
United States locations
- U.S. sites
- 16
- U.S. states
- 11
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Dignity Health Medical Foundation | Carmichael | California | — | — |
| University of California, San Francisco | San Francisco | California | — | — |
| Stanford University | Stanford | California | — | — |
| Yale University | New Haven | Connecticut | — | — |
| Anne Arundel Health System Research Institute | Annapolis | Maryland | — | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | — | — |
| University of Massachusetts | Worcester | Massachusetts | — | — |
| Washington University St. Louis | St Louis | Missouri | — | — |
| Columbia University | New York | New York | 10032 | — |
| Mount Sinai School of Medicine | New York | New York | — | — |
| University of Rochester | Rochester | New York | — | — |
| Cleveland Clinic | Cleveland | Ohio | — | — |
| Oregon Health Sciences University | Portland | Oregon | — | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | — | — |
| University of Virginia | Charlottesville | Virginia | — | — |
| Swedish Medical Center | Seattle | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01490502, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2022 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01490502 live on ClinicalTrials.gov.