Safety and Efficacy of Carboplatin/Paclitaxel and Carboplatin/Paclitaxel/Bevacizumab With and Without Pictilisib in Previously Untreated Advanced or Recurrent Non-small Cell Lung Cancer
Public ClinicalTrials.gov record NCT01493843. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II, Double-Blind, Placebo-Controlled, Randomized Study Evaluating the Safety and Efficacy of Carboplatin/Paclitaxel and Carboplatin/Paclitaxel/Bevacizumab With and Without GDC-0941 in Patients With Previously Untreated Advanced or Recurrent Non-small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This multicenter, randomized, double-blind, placebo-controlled trial will evaluate the efficacy and safety of carboplatin/paclitaxel and carboplatin/paclitaxel/bevacizumab with and without pictilisib in particpants with previously untreated advanced or recurrent non-small cell lung cancer (NSCLC). Particpants will be randomized to receive 4 cycles of carboplatin (C)/paclitaxel (P) and either pictilisib or placebo, with (participants with non-squamous NSCLC) or without (participants with squamous NSCLC) bevacizumab (B). Anticipated time on study treatment is until disease progression or intolerable toxicity occurs. Participants in placebo arms with disease progression may cross over to open-label active pictilisib.
Study identification
- NCT ID
- NCT01493843
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 501 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 20, 2012 (Actual)
- Primary completion
- Mar 30, 2016 (Actual)
- Completion
- Mar 30, 2016 (Actual)
- Last update posted
- Apr 25, 2017
2012 – 2016
United States locations
- U.S. sites
- 44
- U.S. states
- 20
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Oncology | Birmingham | Alabama | 35211 | — |
| Highlands Oncology Group | Rogers | Arkansas | 72758 | — |
| cCare | Encinitas | California | 92024 | — |
| Kaiser Permanente - Oakland | Oakland | California | 94611 | — |
| Desert Hematology Oncology Group | Rancho Mirage | California | 92270 | — |
| Kaiser Permanente - Roseville | Roseville | California | 95661 | — |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95825 | — |
| Southern CA Permanente Med Grp | San Diego | California | 92120 | — |
| Kaiser Permanente | San Francisco | California | 94115 | — |
| K. Permanente - Santa Clara | Santa Clara | California | 95051 | — |
| Stockton Hema Onc Med Grp Inc | Stockton | California | 95204 | — |
| Kaiser Permanente - Vallejo | Vallejo | California | 94589 | — |
| K. Permanente - Walnut Creek | Walnut Creek | California | 94596 | — |
| Hematology Oncology PC; Bennett Cancer Center | Stamford | Connecticut | 06902 | — |
| Lynn Regional Cancer Center West | Boca Raton | Florida | 33486 | — |
| Florida Cancer Specialists - Fort Myers (Colonial Center Dr) | Fort Myers | Florida | 33905 | — |
| Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy) | Jacksonville | Florida | 32256 | — |
| Advanced Medical Specialties | Miami | Florida | 33176 | — |
| Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building) | St. Petersburg | Florida | 33705 | — |
| University Cancer & Blood Center, LLC | Athens | Georgia | 30607 | — |
| Peachtree Hematology & Oncology Consultants, Pc | Atlanta | Georgia | 30318 | — |
| Georgia Cancer Specialists | Atlanta | Georgia | 30341 | — |
| Hematology-Oncology of Indiana, Pc | Indianapolis | Indiana | 46260 | — |
| Franklin Square Hospital | Baltimore | Maryland | 21237 | — |
| Massachusetts General Hospital. | Boston | Massachusetts | 02114 | — |
| Dana Farber Cancer Inst. | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Wayne State University; Hemat/Onc, 4HW CRC | Detroit | Michigan | 48201 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| Va Sierra Nevada Health Care System | Reno | Nevada | 89502 | — |
| San Juan Oncology Associates | Farmington | New Mexico | 87401 | — |
| Roswell Park Cancer Inst. | Buffalo | New York | 14263 | — |
| Piedmont Hematology Oncology Associates | Winston-Salem | North Carolina | 27103 | — |
| Gabrail Cancer Center | Canton | Ohio | 44718 | — |
| The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Univ Hosp Case Medical Center | Cleveland | Ohio | 44106 | — |
| Center for Biomedical Research LLC | Knoxville | Tennessee | 37909 | — |
| The Sarah Cannon Research Inst | Nashville | Tennessee | 37203 | — |
| Vanderbilt | Nashville | Tennessee | 37232 | — |
| University of Texas M.D. Anderson Cancer Center | Houston | Texas | 77030 | — |
| Wellmonth Physician Services | Bristol | Virginia | 24201 | — |
| Blue Ridge Cancer Care - Roanoke | Roanoke | Virginia | 24014 | — |
| VA Puget Sound Health Care Sys | Seattle | Washington | 98108 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 76 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01493843, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 25, 2017 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01493843 live on ClinicalTrials.gov.