Drug-Drug Interaction Study With Pravastatin and Cyclosporine

ClinicalTrials.gov ID: NCT01497483

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Official title

The Pharmacokinetic Interaction Between Pravastatin and Cyclosporine in Healthy Volunteers

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will address the following question: Does cyclosporine affect the pharmacokinetics of pravastatin in healthy volunteers? Studies have shown that cyclosporine inhibits the organic anion transporter required for pravastatin transport into the liver, thus increasing pravastatin levels in the blood. The investigators hypothesize that this inhibition will vary among people based on genetic differences. This knowledge is important to help develop safer and more effective drug therapy with reduced side effects.

Study identification

NCT ID: NCT01497483
Recruitment status: Completed
Study type: Interventional
Phase: Phase 1
Lead sponsor: University of California, San Francisco; Other
Enrollment: 21 participants

Conditions and interventions

Conditions

Healthy

Interventions

Pravastatin alone Drug
Pravastatin and Cyclosporine Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 45 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 2011 (Type not available)
Primary completion: May 2013 (Actual)
Completion: Dec 2013 (Actual)
Last update posted: Jan 16, 2015

2011 – 2013

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
San Francisco General Hosptail	San Francisco	California	94110	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01497483, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jan 16, 2015 · Synced Nov 13, 2026