Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
Public ClinicalTrials.gov record NCT01522443. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-blind, Controlled Trial of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Bone metastases and associated pain are a major cause of morbidity and mortality in castration-resistant prostate cancer (CRPC). Most approved therapies have shown some ability to reduce soft tissue lesions but none meaningfully impacts bone metastases (as demonstrated by lack of resolution of lesions on bone scan with these agents) or the pain associated with these metastases. This study will evaluate the effect of cabozantinib versus mitoxantrone plus prednisone on pain response and bone scan response in men with CRPC.
Study identification
- NCT ID
- NCT01522443
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 119 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2012 (Type not available)
- Primary completion
- Oct 2014 (Actual)
- Completion
- Jan 13, 2015 (Actual)
- Last update posted
- May 23, 2018
2012 – 2015
United States locations
- U.S. sites
- 49
- U.S. states
- 32
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Not listed | Scottsdale | Arizona | 85258 | — |
| Not listed | La Jolla | California | 92093 | — |
| Not listed | Los Angeles | California | 90024 | — |
| Not listed | Los Angeles | California | 90073 | — |
| Not listed | Marina del Rey | California | 90292 | — |
| Not listed | San Diego | California | 92123 | — |
| Not listed | San Francisco | California | 94115 | — |
| Not listed | Santa Barbara | California | 93105 | — |
| Not listed | Stanford | California | 94305 | — |
| Not listed | Aurora | Colorado | 80012 | — |
| Not listed | Littleton | Colorado | 80122 | — |
| Not listed | Washington D.C. | District of Columbia | 20037 | — |
| Not listed | Boca Raton | Florida | 33486 | — |
| Not listed | Athens | Georgia | 30607 | — |
| Not listed | Chicago | Illinois | 60611 | — |
| Not listed | Indianapolis | Indiana | 46202 | — |
| Not listed | Iowa City | Iowa | 52242 | — |
| Not listed | Westwood | Kansas | 66025 | — |
| Not listed | Louisville | Kentucky | 40202 | — |
| Not listed | New Orleans | Louisiana | 70112 | — |
| Not listed | Baltimore | Maryland | 21231 | — |
| Not listed | Detroit | Michigan | 48201 | — |
| Not listed | Detroit | Michigan | 48202 | — |
| Not listed | Minneapolis | Minnesota | 55455 | — |
| Not listed | Tupelo | Mississippi | 38801 | — |
| Not listed | St Louis | Missouri | 63110 | — |
| Not listed | Omaha | Nebraska | 68198 | — |
| Not listed | Las Vegas | Nevada | 89109 | — |
| Not listed | New Brunswick | New Jersey | — | — |
| Not listed | Buffalo | New York | 14263 | — |
| Not listed | New York | New York | 10019 | — |
| Not listed | New York | New York | 10022 | — |
| Not listed | New York | New York | 10065 | — |
| Not listed | Chapel Hill | North Carolina | 27516 | — |
| Not listed | Durham | North Carolina | 27710 | — |
| Not listed | Raleigh | North Carolina | 27607 | — |
| Not listed | Cleveland | Ohio | 44195 | — |
| Not listed | Oklahoma City | Oklahoma | 73104 | — |
| Not listed | Pittsburgh | Pennsylvania | 15232 | — |
| Not listed | Watertown | South Dakota | 57201 | — |
| Not listed | Memphis | Tennessee | 38120 | — |
| Not listed | Nashville | Tennessee | 37203 | — |
| Not listed | Dallas | Texas | 75246 | — |
| Not listed | Round Rock | Texas | 78681 | — |
| Not listed | Salt Lake City | Utah | 84112 | — |
| Not listed | Norfolk | Virginia | 23502 | — |
| Not listed | Seattle | Washington | 98104 | — |
| Not listed | Madison | Wisconsin | 53705 | — |
| Not listed | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01522443, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 23, 2018 · Synced Oct 26, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01522443 live on ClinicalTrials.gov.