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Active, not recruiting Phase 2 Interventional Results available

Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

ClinicalTrials.gov ID: NCT01522976

Public ClinicalTrials.gov record NCT01522976. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 19, 2026, 4:22 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase II/III Study of Azacitidine in Combination With Lenalidomide (NSC-703813) vs. Azacitidine Alone vs. Azacitidine in Combination With Vorinostat (NSC-701852) for Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized phase II/III trial studies how well azacitidine works with or without lenalidomide or vorinostat in treating patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells, stopping them from dividing, or by stopping them from spreading. Lenalidomide may stop the growth of cancer cells by stopping blood flow to the cancer. Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. It is not yet known whether azacitidine is more effective with or without lenalidomide or vorinostat in treating myelodysplastic syndromes or chronic myelomonocytic leukemia.

Study identification

NCT ID
NCT01522976
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
282 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 1, 2012 (Actual)
Primary completion
Jun 1, 2015 (Actual)
Completion
Mar 31, 2027 (Estimated)
Last update posted
Sep 9, 2026

2012 – 2027

United States locations

U.S. sites
280
U.S. states
44
U.S. cities
220
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 —
University of South Alabama Mitchell Cancer Institute Mobile Alabama 36688 —
Mayo Clinic in Arizona Scottsdale Arizona 85259 —
Banner University Medical Center - Tucson Tucson Arizona 85719 —
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 —
John L McClellan Memorial Veterans Hospital Little Rock Arkansas 72205 —
Kaiser Permanente-Deer Valley Medical Center Antioch California 94531 —
City of Hope Comprehensive Cancer Center Duarte California 91010 —
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 —
Kaiser Permanente-Oakland Oakland California 94611 —
Stanford Cancer Institute Palo Alto Palo Alto California 94304 —
Kaiser Permanente-Richmond Richmond California 94801 —
Kaiser Permanente-South Sacramento Sacramento California 95823 —
Kaiser Permanente Sacramento Medical Center Sacramento California 95825 —
Kaiser Permanente-San Francisco San Francisco California 94115 —
Kaiser Permanente-Santa Teresa-San Jose San Jose California 95119 —
Kaiser Permanente-San Rafael San Rafael California 94903 —
Kaiser Permanente Medical Center - Santa Clara Santa Clara California 95051 —
Kaiser Permanente-Santa Rosa Santa Rosa California 95403 —
Sutter Pacific Medical Foundation Santa Rosa California 95403 —
Kaiser Permanente-South San Francisco South San Francisco California 94080 —
Kaiser Permanente-Vallejo Vallejo California 94589 —
Kaiser Permanente-Walnut Creek Walnut Creek California 94596 —
The Medical Center of Aurora Aurora Colorado 80012 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
Boulder Community Foothills Hospital Boulder Colorado 80303 —
Penrose-Saint Francis Healthcare Colorado Springs Colorado 80907 —
AdventHealth Porter Denver Colorado 80210 —
Colorado Blood Cancer Institute Denver Colorado 80218 —
Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado 80218 —
Rocky Mountain Cancer Centers-Midtown Denver Colorado 80218 —
Saint Joseph Hospital - Cancer Centers of Colorado Denver Colorado 80218 —
Rocky Mountain Cancer Centers-Rose Denver Colorado 80220 —
Rose Medical Center Denver Colorado 80220 —
Western States Cancer Research NCORP Denver Colorado 80222 —
Mercy Medical Center Durango Colorado 81301 —
Mountain Blue Cancer Care Center - Swedish Englewood Colorado 80113 —
Swedish Medical Center Englewood Colorado 80113 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
Mountain Blue Cancer Care Center Golden Colorado 80401 —
Banner North Colorado Medical Center Greeley Colorado 80631 —
Rocky Mountain Cancer Centers-Greenwood Village Greenwood Village Colorado 80111 —
CommonSpirit Saint Anthony Hospital Cancer Center Lakewood Colorado 80228 —
Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado 80228 —
AdventHealth Littleton Littleton Colorado 80122 —
Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado 80124 —
Sky Ridge Medical Center Lone Tree Colorado 80124 —
Longmont United Hospital Longmont Colorado 80501 —
Banner North Colorado Medical Center - Loveland Campus Loveland Colorado 80539 —
AdventHealth Parker Parker Colorado 80138 —
Rocky Mountain Cancer Centers-Parker Parker Colorado 80138 —
Saint Mary Corwin Medical Center Pueblo Colorado 81004 —
Intermountain Health Lutheran Hospital Wheat Ridge Colorado 80401 —
University of Connecticut Farmington Connecticut 06030 —
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105 —
The Hospital of Central Connecticut New Britain Connecticut 06050 —
Beebe Medical Center Lewes Delaware 19958 —
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 —
Sibley Memorial Hospital Washington D.C. District of Columbia 20016 —
Veterans Affairs Medical Center -Washington DC Washington D.C. District of Columbia 20422 —
UF Health Cancer Institute - Gainesville Gainesville Florida 32610 —
Jupiter Medical Center Jupiter Florida 33458 —
Mount Sinai Medical Center Miami Beach Florida 33140 —
AdventHealth Orlando Orlando Florida 32803 —
Augusta University Medical Center Augusta Georgia 30912 —
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813 —
Straub Clinic and Hospital Honolulu Hawaii 96813 —
University of Hawaii Cancer Center Honolulu Hawaii 96813 —
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817 —
Kaiser Permanente Moanalua Medical Center Honolulu Hawaii 96819 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Hematology and Oncology Associates Chicago Illinois 60611 —
Northwestern University Chicago Illinois 60611 —
University of Illinois Chicago Illinois 60612 —
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Heartland Cancer Research NCORP Decatur Illinois 62526 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201 —
Illinois CancerCare-Galesburg Galesburg Illinois 61401 —
Illinois CancerCare-Havana Havana Illinois 62644 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Loyola University Medical Center Maywood Illinois 60153 —
Trinity Medical Center Moline Illinois 61265 —
Illinois CancerCare-Monmouth Monmouth Illinois 61462 —
Illinois CancerCare-Community Cancer Center Normal Illinois 61761 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
Swedish American Hospital Rockford Illinois 61104 —
UW Health Carbone Cancer Center Rockford Rockford Illinois 61114 —
Springfield Memorial Hospital Springfield Illinois 62781 —
Carle Cancer Center Urbana Illinois 61801 —
Premier Oncology Hematology Associates Merrillville Indiana 46410 —
McFarland Clinic - Ames Ames Iowa 50010 —
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 —
Siouxland Regional Cancer Center Sioux City Iowa 51101 —
MercyOne Waterloo Cancer Center Waterloo Iowa 50702 —
University of Kansas Cancer Center Kansas City Kansas 66160 —
Kansas City NCI Community Oncology Research Program Prairie Village Kansas 66208 —
Cotton O'Neil Cancer Center / Stormont Vail Health Topeka Kansas 66606 —
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 —
Ochsner Health Center-Summa Baton Rouge Louisiana 70809 —
Ochsner Medical Center Jefferson New Orleans Louisiana 70121 —
LSU Health Sciences Center at Shreveport Shreveport Louisiana 71103 —
Eastern Maine Medical Center Bangor Maine 04401 —
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland 21287 —
Christiana Care - Union Hospital Elkton Maryland 21921 —
Massachusetts General Hospital Cancer Center Boston Massachusetts 02114 —
Dana-Farber Cancer Institute Boston Massachusetts 02215 —
Dana-Farber Cancer Institute at Boston Medical Center - Brighton Brighton Massachusetts 02135 —
Baystate Medical Center Springfield Massachusetts 01199 —
UMass Memorial Medical Center - University Campus Worcester Massachusetts 01655 —
Michigan Cancer Research Consortium NCORP Ann Arbor Michigan 48106 —
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 —
Henry Ford Health Saint John Hospital Detroit Michigan 48236 —
OSF Saint Francis Hospital and Medical Group Escanaba Michigan 49829 —
Cancer Research Consortium of West Michigan NCORP Grand Rapids Michigan 49503 —
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 —
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Trinity Health Muskegon Hospital Muskegon Michigan 49444 —
Lake Huron Medical Center Port Huron Michigan 48060 —
Corewell Health Reed City Hospital Reed City Michigan 49677 —
Munson Medical Center Traverse City Michigan 49684 —
Henry Ford Health Warren Hospital Warren Michigan 48093 —
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 —
Fairview Ridges Hospital Burnsville Minnesota 55337 —
Mercy Hospital Coon Rapids Minnesota 55433 —
Essentia Health Cancer Center Duluth Minnesota 55805 —
Fairview Southdale Hospital Edina Minnesota 55435 —
Unity Hospital Fridley Minnesota 55432 —
Hutchinson Area Health Care Hutchinson Minnesota 55350 —
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109 —
Saint John's Hospital - Healtheast Maplewood Minnesota 55109 —
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
Minneapolis VA Medical Center Minneapolis Minnesota 55417 —
North Memorial Medical Health Center Robbinsdale Minnesota 55422 —
Mayo Clinic in Rochester Rochester Minnesota 55905 —
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 —
Metro Minnesota Community Oncology Research Consortium Saint Louis Park Minnesota 55416 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
Regions Hospital Saint Paul Minnesota 55101 —
United Hospital Saint Paul Minnesota 55102 —
Saint Francis Regional Medical Center Shakopee Minnesota 55379 —
Lakeview Hospital Stillwater Minnesota 55082 —
Ridgeview Medical Center Waconia Minnesota 55387 —
Rice Memorial Hospital Willmar Minnesota 56201 —
Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota 55125 —
University of Mississippi Medical Center Jackson Mississippi 39216 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Veterans Administration Columbia Missouri 65201 —
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia Missouri 65212 —
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111 —
Mercy Hospital Saint Louis St Louis Missouri 63141 —
Saint Louis-Cape Girardeau CCOP St Louis Missouri 63141 —
Billings Clinic Cancer Center Billings Montana 59101 —
Bozeman Health Deaconess Hospital Bozeman Montana 59715 —
Cooper Hospital University Medical Center Camden New Jersey 08103 —
University of New Mexico Cancer Center Albuquerque New Mexico 87106 —
Presbyterian Kaseman Hospital Albuquerque New Mexico 87110 —
Roswell Park Cancer Institute Buffalo New York 14263 —
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 —
North Shore University Hospital Manhasset New York 11030 —
NYU Langone Hospital - Long Island Mineola New York 11501 —
NYP/Weill Cornell Medical Center New York New York 10065 —
University of Rochester Rochester New York 14642 —
Montefiore Medical Center-Weiler Hospital The Bronx New York 10461 —
Montefiore Medical Center - Moses Campus The Bronx New York 10467 —
Randolph Hospital Asheboro North Carolina 27203 —
Wayne Memorial Hospital Goldsboro North Carolina 27534 —
Cone Health Cancer Center Greensboro North Carolina 27403 —
Margaret R Pardee Memorial Hospital Hendersonville North Carolina 28791 —
ECU Health Oncology Kinston Kinston North Carolina 28501 —
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina 28374 —
Annie Penn Memorial Hospital Reidsville North Carolina 27320 —
Iredell Memorial Hospital Statesville North Carolina 28677 —
Southeast Clinical Oncology Research Consortium NCORP Winston-Salem North Carolina 27104 —
Mid Dakota Clinic Bismarck North Dakota 58501 —
Sanford Bismarck Medical Center Bismarck North Dakota 58501 —
Sanford Broadway Medical Center Fargo North Dakota 58122 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
Cleveland Clinic Cancer Center Beachwood Beachwood Ohio 44122 —
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 —
Case Western Reserve University Cleveland Ohio 44106 —
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio 44111 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Riverside Methodist Hospital Columbus Ohio 43214 —
Columbus NCI Community Oncology Research Program Columbus Ohio 43215 —
The Mark H Zangmeister Center Columbus Ohio 43219 —
Mount Carmel Health Center West Columbus Ohio 43222 —
Miami Valley Hospital Dayton Ohio 45409 —
Cleveland Clinic Cancer Center Independence Independence Ohio 44131 —
Marietta Memorial Hospital Marietta Ohio 45750 —
Hillcrest Hospital Cancer Center Mayfield Heights Ohio 44124 —
Licking Memorial Hospital Newark Ohio 43055 —
University Hospitals Parma Medical Center Parma Ohio 44129 —
North Coast Cancer Care Sandusky Ohio 44870 —
Springfield Regional Medical Center Springfield Ohio 45504 —
Cleveland Clinic Cancer Center Strongsville Strongsville Ohio 44136 —
ProMedica Flower Hospital Sylvania Ohio 43560 —
University of Toledo Toledo Ohio 43614 —
Saint Ann's Hospital Westerville Ohio 43081 —
Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio 44691 —
Cancer Care Associates-Norman Norman Oklahoma 73071 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120 —
Legacy Mount Hood Medical Center Gresham Oregon 97030 —
Providence Milwaukie Hospital Milwaukie Oregon 97222 —
Providence Newberg Medical Center Newberg Oregon 97132 —
Providence Willamette Falls Medical Center Oregon City Oregon 97045 —
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103 —
Carlisle Regional Cancer Center Carlisle Pennsylvania 17015 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Doylestown Hospital Doylestown Pennsylvania 18901 —
Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania 18201 —
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 —
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 —
Guthrie Medical Group PC-Robert Packer Hospital Sayre Pennsylvania 18840 —
Reading Hospital West Reading Pennsylvania 19611 —
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 —
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 —
Roper Hospital Charleston South Carolina 29401 —
Saint Francis Hospital Greenville South Carolina 29601 —
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 —
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 —
Spartanburg Medical Center Spartanburg South Carolina 29303 —
Rapid City Regional Hospital Rapid City South Dakota 57701 —
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
Covenant Health Cancer Centers Knoxville Tennessee 37916 —
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 —
The Don and Sybil Harrington Cancer Center Amarillo Texas 79106 —
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —
Sovah Health Martinsville Martinsville Virginia 24112 —
PeaceHealth Southwest Medical Center Vancouver Washington 98664 —
West Virginia University Healthcare Morgantown West Virginia 26506 —
Marshfield Clinic-Chippewa Center Chippewa Falls Wisconsin 54729 —
HSHS Sacred Heart Hospital Eau Claire Wisconsin 54701 —
Marshfield Clinic Cancer Center at Sacred Heart Eau Claire Wisconsin 54701 —
Green Bay Oncology at Saint Vincent Hospital Green Bay Wisconsin 54301-3526 —
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301 —
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303 —
Aurora BayCare Medical Center Green Bay Wisconsin 54311 —
Mercyhealth Hospital and Cancer Center - Janesville Janesville Wisconsin 53548 —
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 —
SSM Health Dean Medical Group - South Madison Campus Madison Wisconsin 53715 —
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143 —
Bay Area Medical Center Marinette Wisconsin 54143 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Marshfield Medical Center Marshfield Wisconsin 54449 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 —
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 —
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin 54154 —
Aspirus Cancer Care-Rhinelander-James Beck Cancer Center Rhinelander Wisconsin 54501 —
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 —
Aspirus Cancer Care - Stevens Point Stevens Point Wisconsin 54481 —
Aurora Medical Center in Summit Summit Wisconsin 53066 —
ProHealth Waukesha Memorial Hospital Waukesha Wisconsin 53188 —
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —
Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin 54494 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT01522976, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 9, 2026 · Synced Oct 19, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT01522976 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →