LUX-Lung 8: A Phase III Trial of Afatinib (BIBW 2992) Versus Erlotinib for the Treatment of Squamous Cell Lung Cancer After at Least One Prior Platinum Based Chemotherapy
Public ClinicalTrials.gov record NCT01523587. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
LUX-Lung 8: A Randomized, Open-label Phase III Trial of Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung as Second-line Therapy Following First-line Platinum-based Chemotherapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This randomised, open-label phase III trial will be performed in patients with advanced squamous cell carcinoma of the lung requiring second-line treatment after receiving first-line platinum-based chemotherapy. The primary objective of this trial is to compare the efficacy of BIBW 2992 to erlotinib as second-line treatment in this group of patients.
Study identification
- NCT ID
- NCT01523587
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 795 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 5, 2012 (Actual)
- Primary completion
- Oct 21, 2013 (Actual)
- Completion
- Dec 27, 2017 (Actual)
- Last update posted
- Feb 15, 2019
2012 – 2017
United States locations
- U.S. sites
- 33
- U.S. states
- 19
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer and Research Centers | Chandler | Arizona | 85224 | — |
| University of California | La Jolla | California | 92093 | — |
| Sutter Medical Group | Sacramento | California | 95816 | — |
| Boca Raton Reginl Hospital-Lynn Cancer Institute | Boca Raton | Florida | 33486 | — |
| Memorial Healthcare System | Hollywood | Florida | 22021 | — |
| Cancer Care of North Florida, PA | Lake City | Florida | 32024 | — |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | — |
| Orchard Healthcare Research Inc | Skokie | Illinois | 60076 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| West Jefferson General Hospital and Cancer Clinic | Marrero | Louisiana | 70072 | — |
| Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| Commonwealth Hematology-Oncology, PC | Lawrence | Massachusetts | 01841 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Queens Medical Associates | Fresh Meadows | New York | 11366 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43201 | — |
| Mid Ohio Oncology/Hematology, Inc | Columbus | Ohio | 43219 | — |
| Kaiser Permanente Northwest | Portland | Oregon | 97227 | — |
| Oncology Hematology Associates of Norhtern Pennsylvania, PC | DuBois | Pennsylvania | 15801 | — |
| Kimmel Cancer Center | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Cancer Center | Philadelphia | Pennsylvania | 19140 | — |
| Spartanburg Regional Medical Center | Spartanburg | South Carolina | 29303 | — |
| Cancer Center of Cookeville Regional Medical Center | Cookeville | Tennessee | 38501 | — |
| Paris Cancer Center (PCC), Texas Oncology | Paris | Texas | 75460 | — |
| Cancer Therapy and Research at UTHSCSA | San Antonio | Texas | 78229 | — |
| Fletcher Allen Health Care | Burlington | Vermont | 05401 | — |
| Blue Ridge Cancer Care | Christiansburg | Virginia | 24382 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 159 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01523587, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 15, 2019 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01523587 live on ClinicalTrials.gov.