A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee
Public ClinicalTrials.gov record NCT01554579. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the efficacy of a single dose level of gefapixant (AF-219/MK-7264) in subjects with moderate to severe pain associated with osteoarthritis (OA) of the knee compared with placebo after 4 weeks of treatment. The study will also assess the safety and tolerability, changes in physical function, stiffness, treatment response and health outcomes.
Study identification
- NCT ID
- NCT01554579
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
- Industry
- Enrollment
- 171 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 29, 2012 (Actual)
- Primary completion
- Nov 11, 2013 (Actual)
- Completion
- Nov 21, 2013 (Actual)
- Last update posted
- Jun 27, 2019
2012 – 2013
United States locations
- U.S. sites
- 34
- U.S. states
- 21
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Afferent Investigative Site | Phoenix | Arizona | 85018 | — |
| Afferent Investigative Site | Phoenix | Arizona | 85027 | — |
| Afferent Investigative Site | San Diego | California | 92108 | — |
| Afferent Investigative Site | Clearwater | Florida | 33756 | — |
| Afferent Investigative Site | Orlando | Florida | 32806 | — |
| Afferent Investigative Site | Pinellas Park | Florida | 33781 | — |
| Afferent Investigative Site | Atlanta | Georgia | 30329 | — |
| Afferent Investigative Site | Wichita | Kansas | 67203 | — |
| Afferent Investigative Site | New Bedford | Massachusetts | 02740 | — |
| Afferent Investigative Site | Watertown | Massachusetts | 02472 | — |
| Afferent Investigative Site | Troy | Michigan | 48098 | — |
| Afferent Investigative Site | Olive Branch | Mississippi | 38654 | — |
| Afferent Investigative Site | Hazelwood | Missouri | 63042 | — |
| Afferent Investigative Site | St Louis | Missouri | 63141 | — |
| Afferent Investigative Site | Albuquerque | New Mexico | 87102 | — |
| Afferent Investigative Site | Asheville | North Carolina | 28803 | — |
| Afferent Investigative Site | Greensboro | North Carolina | 27408 | — |
| Afferent Investigative Site | Winston-Salem | North Carolina | 27103 | — |
| Afferent Investigative Site | Cincinnati | Ohio | 45219 | — |
| Afferent Investigative Site | Toledo | Ohio | 43623 | — |
| Afferent Investigative Site | Medford | Oregon | 97504 | — |
| Afferent Investigative Site | Duncansville | Pennsylvania | 16635 | — |
| Afferent Investigative Site | Warwick | Rhode Island | 02886 | — |
| Afferent Investigative Site | Greer | South Carolina | 29650 | — |
| Afferent Investigative Site | Mt. Pleasant | South Carolina | 29464 | — |
| Afferent Investigative Site | Austin | Texas | 78705 | — |
| Afferent Investigative Site | Dallas | Texas | 75231 | — |
| Afferent Investigative Site | Houston | Texas | 77062 | — |
| Afferent Investigative Site | San Antonio | Texas | 78209 | — |
| Afferent Investigative Site | San Antonio | Texas | 78229 | — |
| Afferent Investigative Site | Clinton | Utah | 84015 | — |
| Afferent Investigative Site | Roanoke | Virginia | 24018 | — |
| Afferent Investigative Site | Renton | Washington | 98057 | — |
| Afferent Investigative Site | Kenosha | Wisconsin | 53142 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01554579, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 27, 2019 · Synced Oct 8, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01554579 live on ClinicalTrials.gov.