Blood Flow and Pain Crises in People With Sickle Cell Disease
Public ClinicalTrials.gov record NCT01568710. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Measurement of the Reactive Hyperemia Index in Sickle Cell Patients During Pain Crisis and After Recovery
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Background: \- Many people with sickle cell disease have repeated episodes of severe pain that lasts for days, requiring hospital care. These episodes, called pain crises, may be caused by changes in blood flow. Researchers want to study blood flow in people with sickle cell disease who are having a pain crisis and compare it with their blood flow after the pain crisis has resolved. They also want to compare these measurements against blood flow in healthy people who do not have sickle cell disease. Objectives: \- To study whether changes in blood flow cause pain crises in people with sickle cell disease. Eligibility: * Individuals at least 18 years of age who have sickle cell disease and are being treated for a pain crisis. * Individuals at least 18 years of age who have sickle cell disease and are not experiencing a pain crisis. * Healthy volunteers matched by age and gender with the participants who have sickle cell disease. Design: * Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected. * Participants having a sickle cell pain crisis will have two visits, one during the crisis and one about 4 weeks after the crisis has resolved. * Participants not having a sickle cell pain crisis will have one or two study visits. Blood samples will be collected during at least one of these visits. * Healthy volunteers will have one or two study visits. Blood samples will be collected during at least one of these visits. * During each visit for all participants, cameras and blood flow monitoring equipment will be used to measure blood flow in the forearm. sickle cell disease.
Study identification
- NCT ID
- NCT01568710
- Recruitment status
- Completed
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 94 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 20, 2012
- Primary completion
- Not listed
- Completion
- Oct 4, 2018
- Last update posted
- Oct 8, 2018
2012 – 2018
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland | 20892 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01568710, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2018 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01568710 live on ClinicalTrials.gov.