A Clinical Trial for the Surgical Treatment of Elderly Distal Radius Fractures
Public ClinicalTrials.gov record NCT01589692. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Clinical Trial for the Surgical Treatment of Elderly Distal Radius Fractures. The Wrist and Radius Injury Surgical Trial (WRIST)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
In the United States, over 300,000 individuals over age 65 suffer from distal radius fractures (DRFs) each year. Despite the frequency of this injury and over 200 years of experience treating DRFs, management of elderly DRFs is still controversial. Close reduction and casting is a nonsurgical technique that is frequently used, but osteoporotic fractures, common in the elderly, often collapse and displace. The three currently applied surgical techniques are close reduction and percutaneous pinning, external fixation with or without percutaneous pinning, and internal fixation with volar locking plating. Preliminary evidence indicates that locking plate fixation can permit elderly patients to move their hands and wrists much sooner in order to return to self-care activities more quickly. Although these outcomes are promising, there is no randomized controlled clinical trial to demonstrate that the more invasive, and perhaps more costly, plating technique is superior to the other simpler approaches. The specific aim of this 24-center randomized controlled trial is to compare outcomes of these three surgical techniques in treating unstable DRFs in the elderly. The secondary aim is to follow a cohort of elderly patients who choose not to have surgery to evaluate outcomes following treatment by close reduction and casting alone. This clinical trial is the most ambitious study in hand surgery by assembling most of the leading centers in North America to collect evidence-based data to guide future treatment of this prevalent injury in the growing elderly population.
Study identification
- NCT ID
- NCT01589692
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 304 participants
Conditions and interventions
Conditions
Interventions
- Open Reduction and Internal Fixation Procedure
- External Fixation Procedure
- Percutaneous Pinning Procedure
- Closed Reduction and casting Procedure
Procedure
Eligibility (public fields only)
- Age range
- 60 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 9, 2012
- Primary completion
- Feb 2, 2018
- Completion
- Jan 7, 2019
- Last update posted
- Feb 10, 2019
2012 – 2019
United States locations
- U.S. sites
- 20
- U.S. states
- 12
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Connecticut | Farmington | Connecticut | 06030 | — |
| Norton Healthcare | Louisville | Kentucky | 40241 | — |
| Johns Hopkins University | Baltimore | Maryland | 21218 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 20114 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| HealthPartners Institute for Education and Research | Saint Paul | Minnesota | 55101 | — |
| North Shore - Long Island Jewish Health System | Great Neck | New York | 11021 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| OrthoCarolina | Charlotte | North Carolina | 28207 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Wake Forest University | Winston-Salem | North Carolina | 27157 | — |
| Kettering Health Network | Centerville | Ohio | 45459 | — |
| The MetroHealth System | Cleveland | Ohio | 44109 | — |
| University of Oklahoma | Oklahoma City | Oklahoma | 73126 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| University of Washington | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01589692, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 10, 2019 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01589692 live on ClinicalTrials.gov.