24-week Study With Open Label Extension of VX-509, an Oral JAK3 Inhibitor, in Subjects Taking Methotrexate
Public ClinicalTrials.gov record NCT01590459. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 24-week, Double-Blind, Randomized, Parallel Group, Placebo-Controlled, Phase 2 Study of Different Doses of VX-509 in Adult Subjects With Active Rheumatoid Arthritis on Stable Methotrexate Therapy With 104-Week Open Label Extension
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed to evaluate the safety and efficacy of VX-509, an oral JAK3 inhibitor, for treatment of subjects with active RA who have had an inadequate response to Methotrexate.
Study identification
- NCT ID
- NCT01590459
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 359 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 2012 (Type not available)
- Primary completion
- Jul 2014 (Actual)
- Completion
- Jul 2014 (Actual)
- Last update posted
- Nov 20, 2015
2012 – 2014
United States locations
- U.S. sites
- 31
- U.S. states
- 17
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Vertex Investigational Site | Birmingham | Alabama | — | — |
| Vertex Investigational Site | Huntsville | Alabama | — | — |
| Vertex Investigational Site | Long Beach | California | — | — |
| Vertex Investigational Site | Tustin | California | — | — |
| Vertex Investigational Site | Boca Raton | Florida | — | — |
| Vertex Investigational Site | Daytona Beach | Florida | — | — |
| Vertex Investigational Site | New Port Richey | Florida | — | — |
| Vertex Investigational Site | North Miami Beach | Florida | — | — |
| Vertex Investigational Site | Ocala | Florida | — | — |
| Vertex Investigational Site | Tampa | Florida | — | — |
| Vertex Investigational Site | Springfield | Illinois | — | — |
| Vertex Investigational Site | Wichita | Kansas | — | — |
| Vertex Investigational Site | Kalamazoo | Michigan | — | — |
| Vertex Investigational Site | St Louis | Missouri | — | — |
| Vertex Investigational Site | Omaha | Nebraska | — | — |
| Vertex Investigational Site | Las Vegas | Nevada | — | — |
| Vertex Investigational Site | Clifton | New Jersey | — | — |
| Vertex Investigational Site | Freehold | New Jersey | — | — |
| Vertex Investigational Site | Brooklyn | New York | — | — |
| Vertex Investigational Site | Charlotte | North Carolina | — | — |
| Vertex Investigational Site | Durham | North Carolina | — | — |
| Vertex Investigational Site | Hickory | North Carolina | — | — |
| Vertex Investigational Site | Oklahoma City | Oklahoma | — | — |
| Vertex Investigational Site | Bethlehem | Pennsylvania | — | — |
| Vertex Investigational Site | Duncansville | Pennsylvania | — | — |
| Vertex Investigational Site | Jackson | Tennessee | — | — |
| Vertex Investigational Site | Austin | Texas | — | — |
| Vertex Investigational Site | Houston | Texas | — | — |
| Vertex Investigational Site | Mesquite | Texas | — | — |
| Vertex Investigational Site | San Antonio | Texas | — | — |
| Vertex Investigational Site | Clarksburg | West Virginia | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 63 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01590459, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 20, 2015 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01590459 live on ClinicalTrials.gov.