ClinicalTrials.gov record
Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors
ClinicalTrials.gov ID: NCT01609790
Public ClinicalTrials.gov record NCT01609790. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase II Double-Blinded Placebo-Controlled Study of Bevacizumab With or Without AMG 386 in Patients With Recurrent Glioblastoma or Gliosarcoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This partially randomized phase II trial with a safety run-in component studies the side effects and how well bevacizumab given with or without trebananib works in treating patients with brain tumors that have come back (recurrent). Immunotherapy with monoclonal antibodies, such as bevacizumab, may induce changes in the body's immune system and interfere with the ability of tumor cells to grow and spread. Trebananib may stop the growth of tumor cells by blocking blood flow to the tumor. It is not yet known whether giving bevacizumab together with trebananib is more effective than bevacizumab alone in treating brain tumors.
Study identification
- NCT ID
- NCT01609790
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 137 participants
Conditions and interventions
Conditions
Interventions
- Bevacizumab Biological
- Laboratory Biomarker Analysis Other
- Pharmacological Study Other
- Placebo Administration Other
- Trebananib Biological
Biological · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 4, 2012 (Actual)
- Primary completion
- Oct 2, 2015 (Actual)
- Completion
- May 20, 2022 (Actual)
- Last update posted
- Jul 21, 2022
2012 – 2022
United States locations
- U.S. sites
- 243
- U.S. states
- 29
- U.S. cities
- 175
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Breast Care and Surgery LLC | Anchorage | Alaska | 99508 | — |
| Alaska Women's Cancer Care | Anchorage | Alaska | 99508 | — |
| Anchorage Oncology Centre | Anchorage | Alaska | 99508 | — |
| Katmai Oncology Group | Anchorage | Alaska | 99508 | — |
| Providence Alaska Medical Center | Anchorage | Alaska | 99508 | — |
| Arizona Oncology-Deer Valley Center | Phoenix | Arizona | 85027 | — |
| Arizona Oncology Services Foundation | Scottsdale | Arizona | 85260 | — |
| Arizona Oncology Associates-West Orange Grove | Tucson | Arizona | 85704 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| Mills-Peninsula Medical Center | Burlingame | California | 94010 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Los Angeles County-USC Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Sutter Cancer Research Consortium | Novato | California | 94945 | — |
| Saint Joseph Hospital - Orange | Orange | California | 92868 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| California Pacific Medical Center-Pacific Campus | San Francisco | California | 94115 | — |
| Sutter Solano Medical Center/Cancer Center | Vallejo | California | 94589 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | 06105 | — |
| The Hospital of Central Connecticut | New Britain | Connecticut | 06050 | — |
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | — |
| William Backus Hospital | Norwich | Connecticut | 06360 | — |
| Broward Health Medical Center | Fort Lauderdale | Florida | 33316 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Piedmont Fayette Hospital | Fayetteville | Georgia | 30214 | — |
| Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia | 30501 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Rush - Copley Medical Center | Aurora | Illinois | 60504 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Carle on Vermilion | Danville | Illinois | 61832 | — |
| Heartland Cancer Research NCORP | Decatur | Illinois | 62526 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | — |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | — |
| NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | 60026 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | — |
| Carle Cancer Institute Normal | Normal | Illinois | 61761 | — |
| OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | 61554 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | 61615 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| The Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Rush-Copley Healthcare Center | Yorkville | Illinois | 60560 | — |
| Menorah Medical Center | Overland Park | Kansas | 66209 | — |
| Saint Luke's South Hospital | Overland Park | Kansas | 66213 | — |
| Kansas City NCI Community Oncology Research Program | Prairie Village | Kansas | 66208 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Maine Medical Center- Scarborough Campus | Scarborough | Maine | 04074 | — |
| Michigan Cancer Research Consortium NCORP | Ann Arbor | Michigan | 48106 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | — |
| Beaumont Hospital - Dearborn | Dearborn | Michigan | 48124 | — |
| Ascension Saint John Hospital | Detroit | Michigan | 48236 | — |
| Green Bay Oncology - Escanaba | Escanaba | Michigan | 49829 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Green Bay Oncology - Iron Mountain | Iron Mountain | Michigan | 49801 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Borgess Medical Center | Kalamazoo | Michigan | 49048 | — |
| Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Saint Joseph Mercy Oakland | Pontiac | Michigan | 48341 | — |
| Lake Huron Medical Center | Port Huron | Michigan | 48060 | — |
| William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | 48073 | — |
| Ascension Saint Mary's Hospital | Saginaw | Michigan | 48601 | — |
| William Beaumont Hospital - Troy | Troy | Michigan | 48085 | — |
| Saint John Macomb-Oakland Hospital | Warren | Michigan | 48093 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Hutchinson Area Health Care | Hutchinson | Minnesota | 55350 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Health Partners Inc | Minneapolis | Minnesota | 55454 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | 55416 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Singing River Hospital | Pascagoula | Mississippi | 39581 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Centerpoint Medical Center LLC | Independence | Missouri | 64057 | — |
| Freeman Health System | Joplin | Missouri | 64804 | — |
| Mercy Hospital Joplin | Joplin | Missouri | 64804 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | 64118 | — |
| Research Medical Center | Kansas City | Missouri | 64132 | — |
| Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | 64086 | — |
| Liberty Radiation Oncology Center | Liberty | Missouri | 64068 | — |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | 65401 | — |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | — |
| Saint Joseph Oncology Inc | Saint Joseph | Missouri | 64507 | — |
| Cancer Research for the Ozarks NCORP | Springfield | Missouri | 65804 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint Louis Cancer and Breast Institute-South City | St Louis | Missouri | 63109 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| New York Oncology Hematology PC - Albany | Albany | New York | 12206 | — |
| New York Oncology Hematology PC - Albany Medical Center | Albany | New York | 12208 | — |
| Hematology Oncology Associates of Central New York-Auburn | Auburn | New York | 13021 | — |
| Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York | 13057 | — |
| Hematology Oncology Associates of Central New York-Liverpool | Liverpool | New York | 13088 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| Hematology Oncology Associates of Central New York-Rome | Rome | New York | 13440 | — |
| Hematology Oncology Associates of Central New York-Onondaga Hill | Syracuse | New York | 13215 | — |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | — |
| Mission Hospital | Asheville | North Carolina | 28801 | — |
| Mountain Radiation Oncology PA | Asheville | North Carolina | 28801 | — |
| AdventHealth Infusion Center Asheville | Asheville | North Carolina | 28803 | — |
| Messino Cancer Centers | Asheville | North Carolina | 28806 | — |
| AdventHealth Hendersonville | Hendersonville | North Carolina | 28792 | — |
| Rutherford Hospital | Rutherfordton | North Carolina | 28139 | — |
| Southeast Clinical Oncology Research Consortium NCORP | Winston-Salem | North Carolina | 27104 | — |
| Summa Health System - Akron Campus | Akron | Ohio | 44304 | — |
| Cleveland Clinic Akron General | Akron | Ohio | 44307 | — |
| Summa Health System - Barberton Campus | Barberton | Ohio | 44203 | — |
| Strecker Cancer Center-Belpre | Belpre | Ohio | 45714 | — |
| Adena Regional Medical Center | Chillicothe | Ohio | 45601 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Columbus Oncology and Hematology Associates Inc | Columbus | Ohio | 43214 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Columbus NCI Community Oncology Research Program | Columbus | Ohio | 43215 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| The Mark H Zangmeister Center | Columbus | Ohio | 43219 | — |
| Mount Carmel Health Center West | Columbus | Ohio | 43222 | — |
| Doctors Hospital | Columbus | Ohio | 43228 | — |
| Delaware Health Center-Grady Cancer Center | Delaware | Ohio | 43015 | — |
| Delaware Radiation Oncology | Delaware | Ohio | 43015 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| Fairfield Medical Center | Lancaster | Ohio | 43130 | — |
| Lancaster Radiation Oncology | Lancaster | Ohio | 43130 | — |
| Marietta Memorial Hospital | Marietta | Ohio | 45750 | — |
| Summa Health Medina Medical Center | Medina | Ohio | 44256 | — |
| Knox Community Hospital | Mount Vernon | Ohio | 43050 | — |
| Licking Memorial Hospital | Newark | Ohio | 43055 | — |
| Newark Radiation Oncology | Newark | Ohio | 43055 | — |
| Southern Ohio Medical Center | Portsmouth | Ohio | 45662 | — |
| University Hospitals Portage Medical Center | Ravenna | Ohio | 44266 | — |
| Springfield Regional Medical Center | Springfield | Ohio | 45505 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| Saint Ann's Hospital | Westerville | Ohio | 43081 | — |
| Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | 43701 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Natalie Warren Bryant Cancer Center at Saint Francis | Tulsa | Oklahoma | 74136 | — |
| Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | 74146 | — |
| Warren Clinic Oncology-Tulsa | Tulsa | Oklahoma | 74146 | — |
| Clackamas Radiation Oncology Center | Clackamas | Oregon | 97015 | — |
| Willamette Valley Cancer Center | Eugene | Oregon | 97401 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | 15009 | — |
| Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | 18015 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | 16121 | — |
| Adams Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| Cherry Tree Cancer Center | Hanover | Pennsylvania | 17331 | — |
| UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | 15901 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17602 | — |
| UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | 15132 | — |
| UPMC Cancer Center-Natrona Heights | Natrona Heights | Pennsylvania | 15065 | — |
| UPMC Jameson | New Castle | Pennsylvania | 16105 | — |
| Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Saint Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Jefferson Regional Radiation Oncology | Pittsburgh | Pennsylvania | 15236 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | — |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | — |
| UPMC Uniontown Hospital Radiation Oncology | Uniontown | Pennsylvania | 15401 | — |
| UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | 15301 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| Main Line Health NCORP | Wynnewood | Pennsylvania | 19096 | — |
| WellSpan Health-York Hospital | York | Pennsylvania | 17403 | — |
| AnMed Health Cancer Center | Anderson | South Carolina | 29621 | — |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Texas Oncology-Austin Midtown | Austin | Texas | 78705 | — |
| Texas Oncology - Central Austin Cancer Center | Austin | Texas | 78731 | — |
| Texas Oncology - South Austin Cancer Center | Austin | Texas | 78745 | — |
| Texas Oncology Bedford | Bedford | Texas | 76022 | — |
| Texas Oncology at Baylor Charles A Sammons Cancer Center | Dallas | Texas | 75246 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| Texas Oncology - Fort Worth Cancer Center | Fort Worth | Texas | 76104 | — |
| Texas Oncology-Grapevine | Grapevine | Texas | 76053 | — |
| Texas Oncology-Longview Cancer Center | Longview | Texas | 75601 | — |
| Texas Oncology-Seton Williamson | Round Rock | Texas | 78665 | — |
| Texas Oncology - Round Rock Cancer Center | Round Rock | Texas | 78681 | — |
| Texas Oncology Cancer Center Sugar Land | Sugar Land | Texas | 77479 | — |
| Tyler Cancer Center | Tyler | Texas | 75702 | — |
| American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | 84003 | — |
| Sandra L Maxwell Cancer Center | Cedar City | Utah | 84720 | — |
| Logan Regional Hospital | Logan | Utah | 84321 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| McKay-Dee Hospital Center | Ogden | Utah | 84403 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | — |
| Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | 84106 | — |
| LDS Hospital | Salt Lake City | Utah | 84143 | — |
| Saint George Regional Medical Center | St. George | Utah | 84770 | — |
| Cancer Care Northwest - Spokane South | Spokane | Washington | 99202 | — |
| Cancer Care Northwest-North Spokane | Spokane | Washington | 99218 | — |
| PeaceHealth Southwest Medical Center | Vancouver | Washington | 98664 | — |
| Compass Oncology Vancouver | Vancouver | Washington | 98684 | — |
| Langlade Hospital and Cancer Center | Antigo | Wisconsin | 54409 | — |
| Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin | 54301-3526 | — |
| Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | 54301 | — |
| Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin | 54303 | — |
| Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | 54303 | — |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
| Holy Family Memorial Hospital | Manitowoc | Wisconsin | 54221 | — |
| Bay Area Medical Center | Marinette | Wisconsin | 54143 | — |
| Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| ProHealth D N Greenwald Center | Mukwonago | Wisconsin | 53149 | — |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | — |
| ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin | 54154 | — |
| Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | 54235-1495 | — |
| Green Bay Oncology - Sturgeon Bay | Sturgeon Bay | Wisconsin | 54235 | — |
| ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin | 53188 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01609790, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 21, 2022 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01609790 live on ClinicalTrials.gov.