A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain
Public ClinicalTrials.gov record NCT01619839. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Enriched-Enrollment, Randomized-Withdrawal, Double-Blind, Placebo-Controlled, Multi-Center Study to Assess the Efficacy, Tolerability, and Safety of NKTR-181 in Opioid-Naïve Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
NKTR-181 is being developed as an analgesic compound for the treatment of moderate to severe chronic pain - active as a mu agonist, but with inherent molecular properties designed to provide a unique clinical profile, including most notably, reduced CNS side effects and an attenuated attractiveness as a target of abuse.
Study identification
- NCT ID
- NCT01619839
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 296 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 31, 2012
- Primary completion
- Jul 31, 2013
- Completion
- Aug 31, 2013
- Last update posted
- Aug 1, 2021
2012 – 2013
United States locations
- U.S. sites
- 34
- U.S. states
- 20
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Investigator Site - Mobile | Mobile | Alabama | 36608 | — |
| Investigator Site - Tuscon | Tucson | Arizona | 85704 | — |
| Investigator Site - Garden Grove | Garden Grove | California | 92844 | — |
| Investigator Site - San Diego | San Diego | California | 92103 | — |
| Investigator Site - Walnut Creek | Walnut Creek | California | 94598 | — |
| Investigator Site - Westlake Village | Westlake Village | California | 91361 | — |
| Investigator Site - Coral Gables | Coral Gables | Florida | 33134 | — |
| Investigator Site - Fort Meyers | Fort Myers | Florida | 33916 | — |
| Investigator Site - Pembroke Pines | Pembroke Pines | Florida | 33028 | — |
| Investigator Site - West Palm Beach | West Palm Beach | Florida | 33409 | — |
| Investigator Site - Weston | Weston | Florida | 33331 | — |
| Investigator Site - Evansville | Evansville | Indiana | 47714 | — |
| Investigator Site - Wichita | Wichita | Kansas | 67207 | — |
| Investigator Site - Louisville | Louisville | Kentucky | 40213 | — |
| Investigator Site - Brockton | Brockton | Massachusetts | 02301 | — |
| Investigator Site - Worcester | Worcester | Massachusetts | 01605 | — |
| Investigator Site - Kansas City | Kansas City | Missouri | 64114 | — |
| Investigator Site - Omaha | Omaha | Nebraska | 68134 | — |
| Investigator Site - Las Vegas | Las Vegas | Nevada | 89102 | — |
| Investigator Site - Las Vegas | Las Vegas | Nevada | 89119 | — |
| Investigator Site - Berlin | Berlin | New Jersey | 08009 | — |
| Investigator Site - Englewood | Englewood | New Jersey | 07631 | — |
| Investigator Site - Greensboro | Greensboro | North Carolina | 27410 | — |
| Investigator Site - Cincinnati | Cincinnati | Ohio | 45219 | — |
| Investigator Site - Oklahoma City | Oklahoma City | Oklahoma | 73109 | — |
| Investigator Site - Duncansville | Duncansville | Pennsylvania | 16635 | — |
| Investigator Site - Philadelphia | Philadelphia | Pennsylvania | 19139 | — |
| Investigator Site - Charleston | Charleston | South Carolina | 29406 | — |
| Investigator Site - Austin | Austin | Texas | 78705 | — |
| Investigator Site - Dallas | Dallas | Texas | 75231 | — |
| Investigator Site - San Antonio | San Antonio | Texas | 78205 | — |
| Investigator Site - San Antonio | San Antonio | Texas | 78209 | — |
| Investigator Site - Salt Lake City | Salt Lake City | Utah | 84106 | — |
| Investigator Site - Kenosha | Kenosha | Wisconsin | 53142 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01619839, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 1, 2021 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01619839 live on ClinicalTrials.gov.