ClinicalTrials.gov record
Completed Phase 2 Interventional Results available

Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

ClinicalTrials.gov ID: NCT01622868

Public ClinicalTrials.gov record NCT01622868. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 16, 2026, 12:44 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery in Combination With Concurrent Lapatinib in Patients With Brain Metastasis From HER2-Positive Breast Cancer - A Collaborative Study of NRG Oncology and KROG

Study identification

NCT ID
NCT01622868
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
143 participants

Conditions and interventions

Interventions

  • Laboratory Biomarker Analysis Other
  • Lapatinib Ditosylate Drug
  • Stereotactic Radiosurgery Radiation
  • Whole-Brain Radiotherapy Radiation

Other · Drug · Radiation

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 5, 2012
Primary completion
Dec 29, 2019
Completion
May 19, 2022
Last update posted
Oct 16, 2023

2012 – 2022

United States locations

U.S. sites
292
U.S. states
37
U.S. cities
213
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233
The Kirklin Clinic at Acton Road Birmingham Alabama 35243
University of South Alabama Mitchell Cancer Institute Mobile Alabama 36688
Saint Joseph's Hospital and Medical Center Phoenix Arizona 85013
Banner University Medical Center - Tucson Tucson Arizona 85719
Sutter Auburn Faith Hospital Auburn California 95602
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California 95603
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704
Mills-Peninsula Medical Center Burlingame California 94010
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California 95682
Mercy San Juan Medical Center Carmichael California 95608
Sutter Davis Hospital Davis California 95616
Epic Care-Dublin Dublin California 94568
Bay Area Breast Surgeons Inc Emeryville California 94608
Epic Care Partners in Cancer Care Emeryville California 94608
Contra Costa Regional Medical Center Martinez California 94553-3156
Memorial Medical Center Modesto California 95355
Palo Alto Medical Foundation-Camino Division Mountain View California 94040
Palo Alto Medical Foundation-Gynecologic Oncology Mountain View California 94040
Sutter Cancer Research Consortium Novato California 94945
Alta Bates Summit Medical Center - Summit Campus Oakland California 94609
Bay Area Tumor Institute Oakland California 94609
Palo Alto Medical Foundation Health Care Palo Alto California 94301
Stanford Cancer Institute Palo Alto Palo Alto California 94304
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California 95661
Sutter Roseville Medical Center Roseville California 95661
Sutter Medical Center Sacramento Sacramento California 95816
Mercy General Hospital Radiation Oncology Center Sacramento California 95819
California Pacific Medical Center-Pacific Campus San Francisco California 94115
Palo Alto Medical Foundation-Santa Cruz Santa Cruz California 95065
Sutter Pacific Medical Foundation Santa Rosa California 95403
Palo Alto Medical Foundation-Sunnyvale Sunnyvale California 94086
Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville California 95687
Sutter Solano Medical Center/Cancer Center Vallejo California 94589
Epic Care Cyberknife Center Walnut Creek California 94597
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105
The Hospital of Central Connecticut New Britain Connecticut 06050
Beebe Medical Center Lewes Delaware 19958
Christiana Gynecologic Oncology LLC Newark Delaware 19713
Delaware Clinical and Laboratory Physicians PA Newark Delaware 19713
Helen F Graham Cancer Center Newark Delaware 19713
Medical Oncology Hematology Consultants PA Newark Delaware 19713
Christiana Care Health System-Christiana Hospital Newark Delaware 19718
Beebe Health Campus Rehoboth Beach Delaware 19971
TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware 19973
Christiana Care Health System-Wilmington Hospital Wilmington Delaware 19801
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136
Miami Cancer Institute Miami Florida 33176
Piedmont Hospital Atlanta Georgia 30309
Northside Hospital Atlanta Georgia 30342
Northside Hospital-Forsyth Cumming Georgia 30041
Piedmont Fayette Hospital Fayetteville Georgia 30214
Northeast Georgia Medical Center-Gainesville Gainesville Georgia 30501
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia 31405
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605
Idaho Urologic Institute-Meridian Meridian Idaho 83642
Rush - Copley Medical Center Aurora Illinois 60504
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612
UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital Chicago Illinois 60657
Carle on Vermilion Danville Illinois 61832
Carle Physician Group-Effingham Effingham Illinois 62401
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
Good Samaritan Regional Health Center Mount Vernon Illinois 62864
Carle Cancer Center Urbana Illinois 61801
Elkhart Clinic Elkhart Indiana 46514-2098
Michiana Hematology Oncology PC-Elkhart Elkhart Indiana 46514
Elkhart General Hospital Elkhart Indiana 46515
Radiation Oncology Associates PC Fort Wayne Indiana 46804
Parkview Hospital Randallia Fort Wayne Indiana 46805
Parkview Regional Medical Center Fort Wayne Indiana 46845
Community Howard Regional Health Kokomo Indiana 46904
IU Health La Porte Hospital La Porte Indiana 46350
Memorial Regional Cancer Center Day Road Mishawaka Indiana 46545
Michiana Hematology Oncology PC-Mishawaka Mishawaka Indiana 46545
Saint Joseph Regional Medical Center-Mishawaka Mishawaka Indiana 46545
Michiana Hematology Oncology PC-Plymouth Plymouth Indiana 46563
Reid Health Richmond Indiana 47374
Memorial Hospital of South Bend South Bend Indiana 46601
Michiana Hematology Oncology PC-South Bend South Bend Indiana 46601
South Bend Clinic South Bend Indiana 46617
Michiana Hematology Oncology PC-Westville Westville Indiana 46391
Saint Luke's Hospital Cedar Rapids Iowa 52402
Central Care Cancer Center - Garden City Garden City Kansas 67846
Central Care Cancer Center - Great Bend Great Bend Kansas 67530
Kansas Institute of Medicine Cancer and Blood Center Lenexa Kansas 66219
Minimally Invasive Surgery Hospital Lenexa Kansas 66219
Menorah Medical Center Overland Park Kansas 66209
Saint Luke's South Hospital Overland Park Kansas 66213
Norton Hospital Pavilion and Medical Campus Louisville Kentucky 40202
Norton Suburban Hospital and Medical Campus Louisville Kentucky 40207
Ochsner Medical Center Jefferson New Orleans Louisiana 70121
Greater Baltimore Medical Center Baltimore Maryland 21204
Boston Medical Center Boston Massachusetts 02118
Bixby Medical Center Adrian Michigan 49221
Hickman Cancer Center Adrian Michigan 49221
Saint Joseph Mercy Hospital Ann Arbor Michigan 48106
University of Michigan Comprehensive Cancer Center Ann Arbor Michigan 48109
Bronson Battle Creek Battle Creek Michigan 49017
Spectrum Health Big Rapids Hospital Big Rapids Michigan 49307
Saint Joseph Mercy Brighton Brighton Michigan 48114
Henry Ford Cancer Institute-Downriver Brownstown Michigan 48183
Saint Joseph Mercy Canton Canton Michigan 48188
Saint Joseph Mercy Chelsea Chelsea Michigan 48118
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038
Beaumont Hospital - Dearborn Dearborn Michigan 48124
Henry Ford Hospital Detroit Michigan 48202
Ascension Saint John Hospital Detroit Michigan 48236
Green Bay Oncology - Escanaba Escanaba Michigan 49829
Genesys Hurley Cancer Institute Flint Michigan 48503
Hurley Medical Center Flint Michigan 48503
Mercy Health Saint Mary's Grand Rapids Michigan 49503
Spectrum Health at Butterworth Campus Grand Rapids Michigan 49503
Green Bay Oncology - Iron Mountain Iron Mountain Michigan 49801
Allegiance Health Jackson Michigan 49201
Bronson Methodist Hospital Kalamazoo Michigan 49007
West Michigan Cancer Center Kalamazoo Michigan 49007
Borgess Medical Center Kalamazoo Michigan 49048
Sparrow Hospital Lansing Michigan 48912
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Mercy Memorial Hospital Monroe Michigan 48162
Toledo Clinic Cancer Centers-Monroe Monroe Michigan 48162
Mercy Health Mercy Campus Muskegon Michigan 49444
Lakeland Hospital Niles Niles Michigan 49120
21st Century Oncology-Pontiac Pontiac Michigan 48341
Saint Joseph Mercy Oakland Pontiac Michigan 48341
Lake Huron Medical Center Port Huron Michigan 48060
Ascension Saint Mary's Hospital Saginaw Michigan 48601
Lakeland Medical Center Saint Joseph Saint Joseph Michigan 49085
Marie Yeager Cancer Center Saint Joseph Michigan 49085
Munson Medical Center Traverse City Michigan 49684
Saint John Macomb-Oakland Hospital Warren Michigan 48093
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322
Metro Health Hospital Wyoming Michigan 49519
Fairview Ridges Hospital Burnsville Minnesota 55337
Mercy Hospital Coon Rapids Minnesota 55433
Fairview Southdale Hospital Edina Minnesota 55435
Unity Hospital Fridley Minnesota 55432
Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota 55369
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109
Saint John's Hospital - Healtheast Maplewood Minnesota 55109
Abbott-Northwestern Hospital Minneapolis Minnesota 55407
Hennepin County Medical Center Minneapolis Minnesota 55415
Health Partners Inc Minneapolis Minnesota 55454
North Memorial Medical Health Center Robbinsdale Minnesota 55422
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416
Regions Hospital Saint Paul Minnesota 55101
United Hospital Saint Paul Minnesota 55102
Ridgeview Medical Center Waconia Minnesota 55387
Rice Memorial Hospital Willmar Minnesota 56201
University of Mississippi Medical Center Jackson Mississippi 39216
Singing River Hospital Pascagoula Mississippi 39581
Central Care Cancer Center - Bolivar Bolivar Missouri 65613
Saint Francis Medical Center Cape Girardeau Missouri 63703
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141
Centerpoint Medical Center LLC Independence Missouri 64057
Mercy Hospital Joplin Joplin Missouri 64804
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111
North Kansas City Hospital Kansas City Missouri 64116
Heartland Hematology and Oncology Associates Incorporated Kansas City Missouri 64118
Research Medical Center Kansas City Missouri 64132
Saint Luke's East - Lee's Summit Lee's Summit Missouri 64086
Liberty Radiation Oncology Center Liberty Missouri 64068
Delbert Day Cancer Institute at PCRMC Rolla Missouri 65401
Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri 65401
Heartland Regional Medical Center Saint Joseph Missouri 64506
Saint Joseph Oncology Inc Saint Joseph Missouri 64507
Mercy Hospital Springfield Springfield Missouri 65804
CoxHealth South Hospital Springfield Missouri 65807
Saint Louis Cancer and Breast Institute-South City St Louis Missouri 63109
Washington University School of Medicine St Louis Missouri 63110
Siteman Cancer Center-South County St Louis Missouri 63129
Mercy Hospital Saint Louis St Louis Missouri 63141
Saint Louis-Cape Girardeau CCOP St Louis Missouri 63141
Renown Regional Medical Center Reno Nevada 89502
Elliot Hospital Manchester New Hampshire 03103
Saint Barnabas Medical Center Livingston New Jersey 07039
Virtua Memorial Mount Holly New Jersey 08060
Virtua Voorhees Voorhees Township New Jersey 08043
University of New Mexico Cancer Center Albuquerque New Mexico 87102
Memorial Medical Center - Las Cruces Las Cruces New Mexico 88011
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn New York 11215
Roswell Park Cancer Institute Buffalo New York 14263
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse New York 13057
Mount Sinai Hospital New York New York 10029
Highland Hospital Rochester New York 14620
University of Rochester Rochester New York 14642
Montefiore Medical Center - Moses Campus The Bronx New York 10467
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599
AdventHealth Hendersonville Hendersonville North Carolina 28792
Iredell Memorial Hospital Statesville North Carolina 28677
Summa Health System - Akron Campus Akron Ohio 44304
Cleveland Clinic Akron General Akron Ohio 44307
Radiation Oncology Center Alliance Ohio 44601
Summa Health System - Barberton Campus Barberton Ohio 44203
Cleveland Clinic Cancer Center Beachwood Beachwood Ohio 44122
UHHS-Chagrin Highlands Medical Center Beachwood Ohio 44122
Toledo Clinic Cancer Centers-Bowling Green Bowling Green Ohio 43402
Cleveland Clinic Mercy Hospital Canton Ohio 44708
Dayton Physicians LLC-Miami Valley South Centerville Ohio 45459
Miami Valley Hospital South Centerville Ohio 45459
Geauga Hospital Chardon Ohio 44024
Oncology Hematology Care Inc-Kenwood Cincinnati Ohio 45236
Case Western Reserve University Cleveland Ohio 44106
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio 44111
Cleveland Clinic Foundation Cleveland Ohio 44195
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210
Good Samaritan Hospital - Dayton Dayton Ohio 45406
Miami Valley Hospital Dayton Ohio 45409
Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio 45415
Miami Valley Hospital North Dayton Ohio 45415
Mercy Cancer Center-Elyria Elyria Ohio 44035
Armes Family Cancer Center Findlay Ohio 45840
Blanchard Valley Hospital Findlay Ohio 45840
Orion Cancer Care Findlay Ohio 45840
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066
Dayton Physicians LLC-Atrium Franklin Ohio 45005
Dayton Physicians LLC-Wayne Greenville Ohio 45331
Wayne Hospital Greenville Ohio 45331
Cleveland Clinic Cancer Center Independence Independence Ohio 44131
Kettering Medical Center Kettering Ohio 45429
Lima Memorial Hospital Lima Ohio 45804
Cleveland Clinic Cancer Center Mansfield Mansfield Ohio 44906
Toledo Clinic Cancer Centers-Maumee Maumee Ohio 43537
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee Ohio 43537
Hillcrest Hospital Cancer Center Mayfield Heights Ohio 44124
Summa Health Medina Medical Center Medina Ohio 44256
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060
UH Seidman Cancer Center at Southwest General Hospital Middleburg Heights Ohio 44130
Saint Charles Hospital Oregon Ohio 43616
Toledo Clinic Cancer Centers-Oregon Oregon Ohio 43616
University Hospitals Parma Medical Center Parma Ohio 44129
University Hospitals Portage Medical Center Ravenna Ohio 44266
UH Seidman Cancer Center at Salem Regional Medical Center Salem Ohio 44460
North Coast Cancer Care Sandusky Ohio 44870
Springfield Regional Cancer Center Springfield Ohio 45504
Springfield Regional Medical Center Springfield Ohio 45505
Cleveland Clinic Cancer Center Strongsville Strongsville Ohio 44136
ProMedica Flower Hospital Sylvania Ohio 43560
Mercy Hospital of Tiffin Tiffin Ohio 44883
Saint Vincent Mercy Medical Center Toledo Ohio 43608
University of Toledo Toledo Ohio 43614
Toledo Community Hospital Oncology Program CCOP Toledo Ohio 43617
Mercy Health - Saint Anne Hospital Toledo Ohio 43623
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623
Dayton Physicians LLC-Upper Valley Troy Ohio 45373
Upper Valley Medical Center Troy Ohio 45373
Fulton County Health Center Wauseon Ohio 43567
UHHS-Westlake Medical Center Westlake Ohio 44145
Cancer Treatment Center Wooster Ohio 44691
Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio 44691
Natalie Warren Bryant Cancer Center at Saint Francis Tulsa Oklahoma 74136
Warren Clinic Oncology-Tulsa Tulsa Oklahoma 74146
Legacy Mount Hood Medical Center Gresham Oregon 97030
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210
Jefferson Abington Hospital Abington Pennsylvania 19001
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017
Pocono Medical Center East Stroudsburg Pennsylvania 18301
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107
Reading Hospital West Reading Pennsylvania 19611
AnMed Health Cancer Center Anderson South Carolina 29621
Medical University of South Carolina Charleston South Carolina 29425
Gibbs Cancer Center-Gaffney Gaffney South Carolina 29341
Gibbs Cancer Center-Pelham Greer South Carolina 29651
Spartanburg Medical Center Spartanburg South Carolina 29303
Covenant Medical Center-Lakeside Lubbock Texas 79410
University of Texas Health Science Center at San Antonio San Antonio Texas 78229
Central Vermont Medical Center/National Life Cancer Treatment Berlin Corners Vermont 05602
University of Vermont Medical Center Burlington Vermont 05401
University of Vermont and State Agricultural College Burlington Vermont 05405
Fredericksburg Oncology Inc Fredericksburg Virginia 22401
Virginia Commonwealth University/Massey Cancer Center Richmond Virginia 23298
Legacy Salmon Creek Hospital Vancouver Washington 98686
Wheeling Hospital/Schiffler Cancer Center Wheeling West Virginia 26003
Green Bay Oncology at Saint Vincent Hospital Green Bay Wisconsin 54301-3526
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay Wisconsin 54303
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303
UW Cancer Center Johnson Creek Johnson Creek Wisconsin 53038
University of Wisconsin Carbone Cancer Center Madison Wisconsin 53792
Holy Family Memorial Hospital Manitowoc Wisconsin 54221
Bay Area Medical Center Marinette Wisconsin 54143
Ascension Columbia Saint Mary's Hospital Ozaukee Mequon Wisconsin 53097
Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee Wisconsin 53211
Medical College of Wisconsin Milwaukee Wisconsin 53226
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin 54154
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin 54235-1495
Green Bay Oncology - Sturgeon Bay Sturgeon Bay Wisconsin 54235

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT01622868, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 16, 2023 · Synced May 16, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT01622868 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →