ClinicalTrials.gov record
Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating
ClinicalTrials.gov ID: NCT01642914
Public ClinicalTrials.gov record NCT01642914. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 3b, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Trial of Linaclotide Administered Orally for 12 Weeks to Patients With Chronic Constipation and Prominent Abdominal Bloating at Baseline
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of linaclotide compared with placebo in patients with chronic constipation (CC) and prominent abdominal bloating. This study includes an up to 3-week screening period and a 2-3 week pretreatment period. Patients who are eligible will be randomized to one of two doses of linaclotide or placebo for 12 weeks. This 12-week study will assess the effects of linaclotide on bowel movement frequency, as well as other abdominal and bowel symptoms of CC.
Study identification
- NCT ID
- NCT01642914
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 487 participants
Conditions and interventions
Conditions
Interventions
- Linaclotide 290 micrograms Drug
- Linaclotide 145 micrograms Drug
- Matching placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2012 (Type not available)
- Primary completion
- May 2013 (Actual)
- Completion
- Aug 2013 (Actual)
- Last update posted
- Apr 26, 2016
2012 – 2013
United States locations
- U.S. sites
- 146
- U.S. states
- 35
- U.S. cities
- 128
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Forest Investigative Site 020 | Chandler | Arizona | 85224 | — |
| Forest Investigative Site 102 | Chandler | Arizona | 85224 | — |
| Forest Investigative Site 149 | Glendale | Arizona | 85308 | — |
| Forest Investigative Site 126 | Goodyear | Arizona | 85395 | — |
| Forest Investigative Site 018 | Phoenix | Arizona | 85018 | — |
| Forest Investigative Site 061 | Phoenix | Arizona | 85020 | — |
| Forest Investigative Site 022 | Scottsdale | Arizona | 85251 | — |
| Forest Investigative Site 079 | Tucson | Arizona | 85704 | — |
| Forest Investigative Site 071 | Tucson | Arizona | 85712 | — |
| Forest Investigative Site 135 | North Little Rock | Arkansas | 72117 | — |
| Forest Investigative Site 106 | Anaheim | California | 92801 | — |
| Forest Investigative Site 104 | Laguna Hills | California | 92653 | — |
| Forest Investigative Site 066 | Mission Hills | California | 91345 | — |
| Forest Investigative Site 095 | San Carlos | California | 94070 | — |
| Forest Investigative Site 009 | San Diego | California | 92108 | — |
| Forest Investigative Site 151 | Santa Monica | California | 90404 | — |
| Forest Investigative Site 010 | Westlake Village | California | 91361 | — |
| Forest Investigative Site 012 | Boulder | Colorado | 80304 | — |
| Forest Investigative Site 041 | Colorado Springs | Colorado | 80904 | — |
| Forest Investigative Site 045 | Colorado Springs | Colorado | 80907 | — |
| Forest Investigative Site 060 | Longmont | Colorado | 80501 | — |
| Forest Investigative Site 007 | Bristol | Connecticut | 06010 | — |
| Forest Investigative Site 153 | Waterbury | Connecticut | 06708 | — |
| Forest Investigative Site 091 | Boynton Beach | Florida | 33426 | — |
| Forest Investigative Site 047 | Bradenton | Florida | 34208 | — |
| Forest Investigative Site 042 | Brooksville | Florida | 34601 | — |
| Forest Investigative Site 133 | Coral Gables | Florida | 33134 | — |
| Forest Investigative Site 131 | DeLand | Florida | 32720 | — |
| Forest Investigative Site 051 | Fort Myers | Florida | 33916 | — |
| Forest Investigative Site 137 | Inverness | Florida | 34452 | — |
| Forest Investigative Site 114 | Jacksonville | Florida | 32205 | — |
| Forest Investigative Site 004 | Jupiter | Florida | 33458 | — |
| Forest Investigative Site 016 | Kissimmee | Florida | 34741 | — |
| Forest Investigative Site 097 | Lauderdale Lakes | Florida | 33319 | — |
| Forest Investigative Site 003 | Miami | Florida | 33143 | — |
| Forest Investigative Site 002 | Miami | Florida | 33183 | — |
| Forest Investigative Site 130 | New Smyrna Beach | Florida | 32168 | — |
| Forest Investigative Site 040 | Ocala | Florida | 34471 | — |
| Forest Investigative Site 083 | Orlando | Florida | 32806 | — |
| Forest Investigative Site 150 | Oviedo | Florida | 32765 | — |
| Forest Investigative Site 132 | Port Orange | Florida | 32129 | — |
| Forest Investigative Site 127 | Seminole | Florida | 33777 | — |
| Forest Investigative Site 087 | St. Petersburg | Florida | 33709 | — |
| Forest Investigative Site 064 | Tampa | Florida | 33606 | — |
| Forest Investigative Site 115 | Zephyrhills | Florida | 33542 | — |
| Forest Investigative Site 021 | Marietta | Georgia | 30060 | — |
| Forest Investigative Site 011 | Marietta | Georgia | 30067 | — |
| Forest Investigative Site 109 | Sandy Springs | Georgia | 30328 | — |
| Forest Investigative Site 037 | Stockbridge | Georgia | 30281 | — |
| Forest Investigative Site 023 | Woodstock | Georgia | 30189 | — |
| Forest Investigative Site 015 | Idaho Falls | Idaho | 83404 | — |
| Forest Investigative Site 122 | Peoria | Illinois | 61602 | — |
| Forest Investigative Site 043 | Rockford | Illinois | 61107 | — |
| Forest Investigative Site 107 | Anderson | Indiana | 46011 | — |
| Forest Investigative Site 117 | Clive | Iowa | 50325 | — |
| Forest Investigative Site 146 | Clive | Iowa | 50325 | — |
| Forest Investigative Site 143 | Davenport | Iowa | 52807 | — |
| Forest Investigative Site 055 | Iowa City | Iowa | 52242 | — |
| Forest Investigative Site 028 | Newton | Kansas | 67114 | — |
| Forest Investigative Site 112 | Overland Park | Kansas | 66215 | — |
| Forest Investigative Site 034 | Wichita | Kansas | 67205 | — |
| Forest Investigative Site 032 | Wichita | Kansas | 67207 | — |
| Forest Investigative Site 128 | Lexington | Kentucky | 40509 | — |
| Forest Investigative Site 134 | Madisonville | Kentucky | 42431 | — |
| Forest Investigative Site 121 | Baton Rouge | Louisiana | 70809 | — |
| Forest Investigative Site 124 | Metairie | Louisiana | 70006 | — |
| Forest Investigative Site 101 | Monroe | Louisiana | 71201 | — |
| Forest Investigative Site 058 | Shreveport | Louisiana | 71101 | — |
| Forest Investigative Site 099 | Shreveport | Louisiana | 71103 | — |
| Forest Investigative Site 062 | Baltimore | Maryland | 21215 | — |
| Forest Investigative Site 008 | Chevy Chase | Maryland | 20815 | — |
| Forest Investigative Site 014 | Hagerstown | Maryland | 21742 | — |
| Forest Investigative Site 024 | Towson | Maryland | 21286 | — |
| Forest Investigative Site 006 | Boston | Massachusetts | 02135 | — |
| Forest Investigative Site 070 | Chesterfield | Michigan | 48047 | — |
| Forest Investigative Site 145 | Traverse City | Michigan | 49684 | — |
| Forest Investigative Site 141 | Jackson | Mississippi | 39202 | — |
| Forest Investigative Site 077 | Fremont | Nebraska | 68025 | — |
| Forest Investigative Site 048 | Omaha | Nebraska | 68134 | — |
| Forest Investigative Site 052 | Henderson | Nevada | 89014 | — |
| Forest Investigative Site 080 | Las Vegas | Nevada | 89121 | — |
| Forest Investigative Site 036 | Clifton | New Jersey | 07012 | — |
| Forest Investigative Site 088 | Marlton | New Jersey | 08053 | — |
| Forest Investigative Site 033 | Vineland | New Jersey | 08360 | — |
| Forest Investigative Site 063 | Albuquerque | New Mexico | 87106 | — |
| Forest Investigative Site 093 | Albuquerque | New Mexico | 87108 | — |
| Forest Investigative Site 044 | Brooklyn | New York | 11206 | — |
| Forest Investigative Site 017 | Great Neck | New York | 11021 | — |
| Forest Investigative Site 142 | Asheboro | North Carolina | 27203 | — |
| Forest Investigative Site 094 | Asheville | North Carolina | 28801 | — |
| Forest Investigative Site 075 | Boone | North Carolina | 28607 | — |
| Forest Investigative Site 123 | Chapel Hill | North Carolina | 27599-7080 | — |
| Forest Investigative Site 140 | Davidson | North Carolina | 28036 | — |
| Forest Investigative Site 039 | Fayetteville | North Carolina | 28304 | — |
| Forest Investigative Site 031 | Greensboro | North Carolina | 27403 | — |
| Forest Investigative Site 029 | Greensboro | North Carolina | 27408 | — |
| Forest Investigative Site 078 | Greensboro | North Carolina | 27408 | — |
| Forest Investigative Site 084 | Harrisburg | North Carolina | 28075 | — |
| Forest Investigative Site 073 | Hickory | North Carolina | 28601 | — |
| Forest Investigative Site 050 | Hickory | North Carolina | 28602 | — |
| Forest Investigative Site 139 | High Point | North Carolina | 27262 | — |
| Forest Investigative Site 027 | Raleigh | North Carolina | 27612 | — |
| Forest Investigative Site 119 | Statesville | North Carolina | 28625 | — |
| Forest Investigative Site 089 | Wilmington | North Carolina | 28401 | — |
| Forest Investigative Site 074 | Winston-Salem | North Carolina | 27103 | — |
| Forest Investigative Site 025 | Cincinnati | Ohio | 45242 | — |
| Forest Investigative Site 120 | Cincinnati | Ohio | 45249 | — |
| Forest Investigative Site 056 | Cleveland | Ohio | 44122 | — |
| Forest Investigative Site 026 | Columbus | Ohio | 43215 | — |
| Forest Investigative Site 098 | Dayton | Ohio | 45415 | — |
| Forest Investigative Site 090 | Dayton | Ohio | 45432 | — |
| Forest Investigative Site 085 | Mentor | Ohio | 44060 | — |
| Forest Investigative Site 068 | Wadsworth | Ohio | 44281 | — |
| Forest Investigative Site 118 | Oklahoma City | Oklahoma | 73104 | — |
| Forest Investigative Site 081 | Levittown | Pennsylvania | 19056 | — |
| Forest Investigative Site 001 | Pittsburgh | Pennsylvania | 15206 | — |
| Forest Investigative Site 110 | Reading | Pennsylvania | 19606 | — |
| Forest Investigative Site 116 | Greer | South Carolina | 29650 | — |
| Forest Investigative Site 046 | Simpsonville | South Carolina | 29681 | — |
| Forest Investigative Site 092 | Dakota Dunes | South Dakota | 57049 | — |
| Forest Investigative Site 129 | Chattanooga | Tennessee | 37421 | — |
| Forest Investigative Site 138 | Kingsport | Tennessee | 37660 | — |
| Forest Investigative Site 125 | Austin | Texas | 78756 | — |
| Forest Investigative Site 035 | Dallas | Texas | 75231 | — |
| Forest Investigative Site 005 | Dallas | Texas | 75234 | — |
| Forest Investigative Site 111 | Fort Worth | Texas | 76135 | — |
| Forest Investigative Site 100 | Houston | Texas | 77034 | — |
| Forest Investigative Site 067 | Katy | Texas | 77450 | — |
| Forest Investigative Site 049 | Pasadena | Texas | 77505 | — |
| Forest Investigative Site 030 | San Antonio | Texas | 78209 | — |
| Forest Investigative Site 076 | San Antonio | Texas | 78229 | — |
| Forest Investigative Site 065 | Sugarland | Texas | 77479 | — |
| Forest Investigative Site 019 | Ogden | Utah | 84405 | — |
| Forest Investigative Site 105 | Salt Lake City | Utah | 84107 | — |
| Forest Investigative Site 113 | Sandy City | Utah | 84094 | — |
| Forest Investigative Site 053 | Charlottesville | Virginia | 22911 | — |
| Forest Investigative Site 108 | Chesapeake | Virginia | 23320 | — |
| Forest Investigative Site 136 | Chesapeake | Virginia | 23320 | — |
| Forest Investigative Site 148 | Christiansburg | Virginia | 24073 | — |
| Forest Investigative Site 072 | Lynchburg | Virginia | 24502 | — |
| Forest Investigative Site 069 | Newport News | Virginia | 23606 | — |
| Forest Investigative Site 013 | Norfolk | Virginia | 23502 | — |
| Forest Investigative Site 038 | Richmond | Virginia | 23294 | — |
| Forest Investigative Site 103 | Spokane | Washington | 99208 | — |
| Forest Investigative Site 082 | La Crosse | Wisconsin | 54601 | — |
| Forest Investigative Site 096 | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01642914, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 26, 2016 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01642914 live on ClinicalTrials.gov.