Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus

ClinicalTrials.gov ID: NCT01643226

Public ClinicalTrials.gov record NCT01643226. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Jul 22, 2026, 12:25 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multi-Center, Randomized, Placebo-Controlled Evaluation of the Safety and Efficacy of the KXL System With VibeX (Riboflavin Ophthalmic Solution) for Corneal Collagen Cross-Linking in Eyes With Keratoconus

Study identification

NCT ID: NCT01643226
Recruitment status: Completed
Study type: Interventional
Phase: Phase 3
Lead sponsor: Glaukos Corporation; Industry
Enrollment: 230 participants

Conditions and interventions

Conditions

Keratoconus

Interventions

riboflavin solution Drug
placebo solution Drug
KXL System Device

Drug · Device

Eligibility (public fields only)

Age range: 12 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 30, 2012
Primary completion: Jun 30, 2015
Completion: Aug 31, 2016
Last update posted: Apr 25, 2021

2012 – 2016

United States locations

U.S. sites: 8
U.S. states: 8
U.S. cities: 8

Facility	City	State	ZIP	Site status
Gordon -Weiss Vision Institute	San Diego	California	92122	—
Price Vision Group	Indianapolis	Indiana	46260	—
Durrie Vision	Overland Park	Kansas	66211	—
Cornea & Laser Eye Institute; Hersh Vision Group	Teaneck	New Jersey	07666	—
Columbia University Harkness Eye Institute	New York	New York	10032	—
Cleveland Clinic Cole Eye Institute	Cleveland	Ohio	44195	—
UPMC Eye Center	Pittsburgh	Pennsylvania	15213	—
See Clearly Vision	McLean	Virginia	22102	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01643226, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 25, 2021 · Synced Jul 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT01643226 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →