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ClinicalTrials.gov record
Completed Phase 1Phase 2 Interventional Results available

Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme

ClinicalTrials.gov ID: NCT01648348

Public ClinicalTrials.gov record NCT01648348. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Jun 25, 2026, 11:45 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase I/Comparative Randomized Phase II Trial of TRC105 Plus Bevacizumab Versus Bevacizumab in Bevacizumab-Naive Patients With Recurrent Glioblastoma Multiforme

Study identification

NCT ID
NCT01648348
Recruitment status
Completed
Study type
Interventional
Phase
Phase 1, Phase 2
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
116 participants

Conditions and interventions

Interventions

  • Anti-Endoglin Chimeric Monoclonal Antibody TRC105 Biological
  • Bevacizumab Biological
  • Laboratory Biomarker Analysis Other
  • Pharmacological Study Other
  • Quality-of-Life Assessment Other

Biological · Other

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 31, 2012
Primary completion
May 10, 2016
Completion
Apr 14, 2017
Last update posted
May 22, 2018

2012 – 2017

United States locations

U.S. sites
308
U.S. states
33
U.S. cities
222
Facility City State ZIP Site status
University of Arkansas for Medical Sciences Little Rock Arkansas 72205
Saint Jude Medical Center Fullerton California 92835
Saint Joseph Hospital - Orange Orange California 92868
Sharp Memorial Hospital San Diego California 92123
UCSF Medical Center-Mount Zion San Francisco California 94115
UCSF Medical Center-Parnassus San Francisco California 94143
Greenwich Hospital Greenwich Connecticut 06830
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105
Stamford Hospital/Bennett Cancer Center Stamford Connecticut 06904
Beebe Medical Center Lewes Delaware 19958
Christiana Gynecologic Oncology LLC Newark Delaware 19713
Delaware Clinical and Laboratory Physicians PA Newark Delaware 19713
Helen F Graham Cancer Center Newark Delaware 19713
Medical Oncology Hematology Consultants PA Newark Delaware 19713
Regional Hematology and Oncology PA Newark Delaware 19713
Christiana Care Health System-Christiana Hospital Newark Delaware 19718
Beebe Health Campus Rehoboth Beach Delaware 19971
Nanticoke Memorial Hospital Seaford Delaware 19973
Christiana Care Health System-Wilmington Hospital Wilmington Delaware 19801
Mayo Clinic in Florida Jacksonville Florida 32224-9980
Mount Sinai Medical Center Miami Beach Florida 33140
Florida Hospital Orlando Orlando Florida 32803
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706
Kootenai Medical Center Coeur d'Alene Idaho 83814
Kootenai Cancer Center Post Falls Idaho 83854
Kootenai Cancer Clinic Sandpoint Idaho 83864
Saint Joseph Medical Center Bloomington Illinois 61701
Illinois CancerCare-Bloomington Bloomington Illinois 61704
Illinois CancerCare-Canton Canton Illinois 61520
Memorial Hospital of Carbondale Carbondale Illinois 62902
Illinois CancerCare-Carthage Carthage Illinois 62321
Centralia Oncology Clinic Centralia Illinois 62801
Northwestern University Chicago Illinois 60611
Cancer Care Center of Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Crossroads Cancer Center Effingham Illinois 62401
Illinois CancerCare-Eureka Eureka Illinois 61530
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201
Illinois CancerCare-Galesburg Galesburg Illinois 61401
Western Illinois Cancer Treatment Center Galesburg Illinois 61401
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026
Hematology Oncology Associates of Illinois-Highland Park Highland Park Illinois 60035
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035
Presence Saint Mary's Hospital Kankakee Illinois 60901
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443
NorthShore Hematology Oncology-Libertyville Libertyville Illinois 60048
Illinois CancerCare-Macomb Macomb Illinois 61455
Garneau, Stewart C MD (UIA Investigator) Moline Illinois 61265
Spector, David MD (UIA Investigator) Moline Illinois 61265
Trinity Medical Center Moline Illinois 61265
Illinois Cancer Specialists-Niles Niles Illinois 60714
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350
Radiation Oncology of Northern Illinois Ottawa Illinois 61350
Illinois CancerCare-Pekin Pekin Illinois 61554
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois 61554
Methodist Medical Center of Illinois Peoria Illinois 61603
Illinois CancerCare-Peoria Peoria Illinois 61615
OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois 61615
OSF Saint Francis Medical Center Peoria Illinois 61637
Illinois CancerCare-Peru Peru Illinois 61354
Valley Radiation Oncology Peru Illinois 61354
Illinois CancerCare-Princeton Princeton Illinois 61356
Hematology Oncology Associates of Illinois - Skokie Skokie Illinois 60076
Central Illinois Hematology Oncology Center Springfield Illinois 62702
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Memorial Medical Center Springfield Illinois 62781
Cancer Care Specialists of Illinois-Swansea Swansea Illinois 62226
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555
Michiana Hematology Oncology PC-Crown Point Crown Point Indiana 46307
Elkhart Clinic Elkhart Indiana 46514-2098
Michiana Hematology Oncology PC-Elkhart Elkhart Indiana 46514
Elkhart General Hospital Elkhart Indiana 46515
Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana 46202
Community Howard Regional Health Kokomo Indiana 46904
IU Health La Porte Hospital La Porte Indiana 46350
Memorial Regional Cancer Center Day Road Mishawaka Indiana 46544
Michiana Hematology Oncology PC-Mishawaka Mishawaka Indiana 46545
Saint Joseph Regional Medical Center-Mishawaka Mishawaka Indiana 46545
Michiana Hematology Oncology PC-Plymouth Plymouth Indiana 46563
Reid Health Richmond Indiana 47374
Memorial Hospital of South Bend South Bend Indiana 46601
Michiana Hematology Oncology PC-South Bend South Bend Indiana 46601
South Bend Clinic South Bend Indiana 46617
Northern Indiana Cancer Research Consortium South Bend Indiana 46628
Michiana Hematology Oncology PC-Westville Westville Indiana 46391
Mary Greeley Medical Center Ames Iowa 50010
McFarland Clinic PC-William R Bliss Cancer Center Ames Iowa 50010
Constantinou, Costas L MD (UIA Investigator) Bettendorf Iowa 52722
McFarland Clinic PC-Boone Boone Iowa 50036
Mercy Hospital Cedar Rapids Iowa 52403
Oncology Associates at Mercy Medical Center Cedar Rapids Iowa 52403
McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa 50501
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242
McFarland Clinic PC-Jefferson Jefferson Iowa 50129
McFarland Clinic PC-Marshalltown Marshalltown Iowa 50158
Siouxland Regional Cancer Center Sioux City Iowa 51101
Mercy Medical Center-Sioux City Sioux City Iowa 51104
Saint Luke's Regional Medical Center Sioux City Iowa 51104
Cancer Center of Kansas - Chanute Chanute Kansas 66720
Cancer Center of Kansas - Dodge City Dodge City Kansas 67801
Cancer Center of Kansas - El Dorado El Dorado Kansas 67042
Cancer Center of Kansas - Fort Scott Fort Scott Kansas 66701
Cancer Center of Kansas-Independence Independence Kansas 67301
Cancer Center of Kansas-Kingman Kingman Kansas 67068
Lawrence Memorial Hospital Lawrence Kansas 66044
Cancer Center of Kansas-Liberal Liberal Kansas 67905
Cancer Center of Kansas-Manhattan Manhattan Kansas 66502
Cancer Center of Kansas - McPherson McPherson Kansas 67460
Cancer Center of Kansas - Newton Newton Kansas 67114
Cancer Center of Kansas - Parsons Parsons Kansas 67357
Cancer Center of Kansas - Pratt Pratt Kansas 67124
Cancer Center of Kansas - Salina Salina Kansas 67401
Cancer Center of Kansas - Wellington Wellington Kansas 67152
Associates In Womens Health Wichita Kansas 67208
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas 67208
Cancer Center of Kansas - Wichita Wichita Kansas 67214
Via Christi Regional Medical Center Wichita Kansas 67214
Wichita NCI Community Oncology Research Program Wichita Kansas 67214
Cancer Center of Kansas - Winfield Winfield Kansas 67156
Baptist Health Corbin Corbin Kentucky 40701
Oncology Hematology Care Inc-Crestview Crestview Hills Kentucky 41017
Hardin Memorial Hospital Elizabethtown Kentucky 42701
Baptist Health Lexington Lexington Kentucky 40503
Baptist Health Madisonville/Merle Mahr Cancer Center Madisonville Kentucky 42431
Baptist Health Paducah Paducah Kentucky 42003
Eastern Maine Medical Center Bangor Maine 04401
Lafayette Family Cancer Center-EMMC Brewer Maine 04412
Maine Center for Cancer Medicine-Scarborough Scarborough Maine 04074
Massachusetts General Hospital Cancer Center Boston Massachusetts 02114
Dana-Farber Cancer Institute Boston Massachusetts 02115
Massachusetts General Hospital Charlestown Massachusetts 02129
Bixby Medical Center Adrian Michigan 49221
Hickman Cancer Center Adrian Michigan 49221
Saint Joseph Mercy Hospital Ann Arbor Michigan 48106-0995
Bronson Battle Creek Battle Creek Michigan 49017
Beaumont Hospital-Dearborn Dearborn Michigan 48124
Saint John Hospital and Medical Center Detroit Michigan 48236
Hurley Medical Center Flint Michigan 48502
Genesys Hurley Cancer Institute Flint Michigan 48503
Mercy Health Saint Mary's Grand Rapids Michigan 49503
Spectrum Health at Butterworth Campus Grand Rapids Michigan 49503
Allegiance Health Jackson Michigan 49201
Borgess Medical Center Kalamazoo Michigan 49001
Bronson Methodist Hospital Kalamazoo Michigan 49007
West Michigan Cancer Center Kalamazoo Michigan 49007
Sparrow Hospital Lansing Michigan 48912
Saint Mary Mercy Hospital Livonia Michigan 48154
Mercy Memorial Hospital Monroe Michigan 48162
Toledo Clinic Cancer Centers-Monroe Monroe Michigan 48162
Mercy Health Mercy Campus Muskegon Michigan 49444
Lakeland Community Hospital Niles Michigan 49120
Saint Joseph Mercy Oakland Pontiac Michigan 48341
Lake Huron Medical Center Port Huron Michigan 48060
Spectrum Health Reed City Hospital Reed City Michigan 49677
Saint Mary's of Michigan Saginaw Michigan 48601
Lakeland Hospital Saint Joseph Michigan 49085
Marie Yeager Cancer Center Saint Joseph Michigan 49085
Munson Medical Center Traverse City Michigan 49684
Saint John Macomb-Oakland Hospital Warren Michigan 48093
Ann Arbor Hematology -Oncology Associates Ypsilanti Michigan 48197
Fairview Ridges Hospital Burnsville Minnesota 55337
Mercy Hospital Coon Rapids Minnesota 55433
Essentia Health Cancer Center Duluth Minnesota 55805
Essentia Health Saint Mary's Medical Center Duluth Minnesota 55805
Miller-Dwan Hospital Duluth Minnesota 55805
Saint Luke's Hospital of Duluth Duluth Minnesota 55805
Fairview-Southdale Hospital Edina Minnesota 55435
Unity Hospital Fridley Minnesota 55432
Hutchinson Area Health Care Hutchinson Minnesota 55350
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109
Saint John's Hospital - Healtheast Maplewood Minnesota 55109
Abbott-Northwestern Hospital Minneapolis Minnesota 55407
Hennepin County Medical Center Minneapolis Minnesota 55415
Health Partners Inc Minneapolis Minnesota 55454
New Ulm Medical Center New Ulm Minnesota 56073
North Memorial Medical Health Center Robbinsdale Minnesota 55422
Mayo Clinic Rochester Minnesota 55905
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303
Saint Cloud Hospital Saint Cloud Minnesota 56303
Metro Minnesota Community Oncology Research Consortium Saint Louis Park Minnesota 55416
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416
Regions Hospital Saint Paul Minnesota 55101
United Hospital Saint Paul Minnesota 55102
Saint Francis Regional Medical Center Shakopee Minnesota 55379
Lakeview Hospital Stillwater Minnesota 55082
Ridgeview Medical Center Waconia Minnesota 55387
Rice Memorial Hospital Willmar Minnesota 56201
Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota 55125
Parkland Health Center-Bonne Terre Bonne Terre Missouri 63628
Saint Francis Medical Center Cape Girardeau Missouri 63703
Southeast Cancer Center Cape Girardeau Missouri 63703
Capital Region Medical Center-Goldschmidt Cancer Center Jefferson City Missouri 65109
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670
Washington University School of Medicine St Louis Missouri 63110
Missouri Baptist Medical Center St Louis Missouri 63131
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080
Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri 63127
Billings Clinic Cancer Center Billings Montana 59101
Montana Cancer Consortium NCORP Billings Montana 59101
Saint Vincent Healthcare Billings Montana 59101
Bozeman Deaconess Hospital Bozeman Montana 59715
Saint James Community Hospital and Cancer Treatment Center Butte Montana 59701
Benefis Healthcare- Sletten Cancer Institute Great Falls Montana 59405
Saint Peter's Community Hospital Helena Montana 59601
Kalispell Regional Medical Center Kalispell Montana 59901
Saint Patrick Hospital - Community Hospital Missoula Montana 59802
Community Medical Hospital Missoula Montana 59804
University of Nebraska Medical Center Omaha Nebraska 68198
New Hampshire Oncology Hematology PA-Concord Concord New Hampshire 03301
New Hampshire Oncology Hematology PA-Hooksett Hooksett New Hampshire 03106
LRGHealthcare-Lakes Region General Hospital Laconia New Hampshire 03246
Dartmouth Hitchcock Medical Center Lebanon New Hampshire 03756
Cooper Hospital University Medical Center Camden New Jersey 08103
MD Anderson Cancer Center at Cooper-Voorhees Voorhees Township New Jersey 08043
Hematology Oncology Associates of Central New York-Auburn Auburn New York 13021
Hematology Oncology Associates of Central New York-East Syracuse East Syracuse New York 13057
Mount Sinai Hospital New York New York 10029
Memorial Sloan-Kettering Cancer Center New York New York 10065
State University of New York Upstate Medical University Syracuse New York 13210
Hematology Oncology Associates of Central New York-Onondaga Hill Syracuse New York 13215
Wayne Memorial Hospital Goldsboro North Carolina 27534
Kinston Medical Specialists PA Kinston North Carolina 28501
Wake Forest University Health Sciences Winston-Salem North Carolina 27157
Altru Cancer Center Grand Forks North Dakota 58201
Strecker Cancer Center-Belpre Belpre Ohio 45714
Toledo Clinic Cancer Centers-Bowling Green Bowling Green Ohio 43402
Adena Regional Medical Center Chillicothe Ohio 45601
Oncology Hematology Care Inc-Eden Park Cincinnati Ohio 45202
Oncology Hematology Care Inc-Mercy West Cincinnati Ohio 45211
Oncology Hematology Care Inc - Anderson Cincinnati Ohio 45230
Oncology Hematology Care Inc-Kenwood Cincinnati Ohio 45236
Oncology Hematology Care Inc-Blue Ash Cincinnati Ohio 45242
Columbus Oncology and Hematology Associates Inc Columbus Ohio 43214
Riverside Methodist Hospital Columbus Ohio 43214
Columbus NCI Community Oncology Research Program Columbus Ohio 43215
Grant Medical Center Columbus Ohio 43215
The Mark H Zangmeister Center Columbus Ohio 43219
Mount Carmel Health Center West Columbus Ohio 43222
Doctors Hospital Columbus Ohio 43228
Good Samaritan Hospital - Dayton Dayton Ohio 45406
Miami Valley Hospital Dayton Ohio 45409
Samaritan North Health Center Dayton Ohio 45415
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015
Delaware Radiation Oncology Delaware Ohio 43015
Grady Memorial Hospital Delaware Ohio 43015
Oncology Hematology Care Inc-Healthplex Fairfield Ohio 45014
Blanchard Valley Hospital Findlay Ohio 45840
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066
Wayne Hospital Greenville Ohio 45331
Kettering Medical Center Kettering Ohio 45429
Fairfield Medical Center Lancaster Ohio 43130
Lima Memorial Hospital Lima Ohio 45804
Marietta Memorial Hospital Marietta Ohio 45750
OneHealth Marion General Hospital Marion Ohio 43302
Toledo Clinic Cancer Centers-Maumee Maumee Ohio 43537
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee Ohio 43537
Knox Community Hospital Mount Vernon Ohio 43050
Licking Memorial Hospital Newark Ohio 43055
Newark Radiation Oncology Newark Ohio 43055
Saint Charles Hospital Oregon Ohio 43616
Toledo Clinic Cancer Centers-Oregon Oregon Ohio 43616
Southern Ohio Medical Center Portsmouth Ohio 45662
Springfield Regional Medical Center Springfield Ohio 45505
Flower Hospital Sylvania Ohio 43560
Mercy Hospital of Tiffin Tiffin Ohio 44883
Saint Vincent Mercy Medical Center Toledo Ohio 43608
University of Toledo Toledo Ohio 43614
Toledo Community Hospital Oncology Program CCOP Toledo Ohio 43617
Mercy Saint Anne Hospital Toledo Ohio 43623
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623
Upper Valley Medical Center Troy Ohio 45373
Fulton County Health Center Wauseon Ohio 43567
Saint Ann's Hospital Westerville Ohio 43081
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma 74146
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017
PinnacleHealth Cancer Center-Community Campus Harrisburg Pennsylvania 17109
Reading Hospital West Reading Pennsylvania 19611
Greenville Health System Cancer Institute-Easley Easley South Carolina 29640
Greenville Health System Cancer Institute-Andrews Greenville South Carolina 29605
Greenville Health System Cancer Institute-Butternut Greenville South Carolina 29605
Greenville Health System Cancer Institute-Faris Greenville South Carolina 29605
Greenville Memorial Hospital Greenville South Carolina 29605
Greenville Health System Cancer Institute-Eastside Greenville South Carolina 29615
Greenville Health System Cancer Institute-Greer Greer South Carolina 29650
Greenville Health System Cancer Institute-Seneca Seneca South Carolina 29672
Greenville Health System Cancer Institute-Spartanburg Spartanburg South Carolina 29307
Rapid City Regional Hospital Rapid City South Dakota 57701
University Medical Center Brackenridge Austin Texas 78701
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112
University of Virginia Cancer Center Charlottesville Virginia 22908
Fredericksburg Oncology Inc Fredericksburg Virginia 22401
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601
University of Wisconsin Hospital and Clinics Madison Wisconsin 53792
Community Memorial Hospital Menomonee Falls Wisconsin 53051
Froedtert and the Medical College of Wisconsin Milwaukee Wisconsin 53226
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066
ProHealth Waukesha Memorial Hospital Waukesha Wisconsin 53188
Rocky Mountain Oncology Casper Wyoming 82609
Big Horn Basin Cancer Center Cody Wyoming 82414
Billings Clinic-Cody Cody Wyoming 82414
Welch Cancer Center Sheridan Wyoming 82801

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT01648348, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 22, 2018 · Synced Jun 25, 2026

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