Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC)
Public ClinicalTrials.gov record NCT01672853. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Dose-Ranging, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Safety and Efficacy of GS-6624, a Monoclonal Antibody Against Lysyl Oxidase Like 2 (LOXL2) in Subjects With Primary Sclerosing Cholangitis (PSC)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate whether simtuzumab (GS-6624) is effective at preventing the progression of liver fibrosis in adults with primary sclerosing cholangitis (PSC).
Study identification
- NCT ID
- NCT01672853
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 235 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 4, 2013 (Actual)
- Primary completion
- Aug 8, 2016 (Actual)
- Completion
- Aug 24, 2016 (Actual)
- Last update posted
- Oct 22, 2019
2013 – 2016
United States locations
- U.S. sites
- 43
- U.S. states
- 23
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| University of Arizona Health Sciences Center | Tucson | Arizona | 85724 | — |
| Southern California Liver Center | Chula Vista | California | 91910 | — |
| Southern California Liver Centers | Coronado | California | 92118 | — |
| Scripps Clinic | La Jolla | California | 92037 | — |
| Verterans Adminstration Hospital | Palo Alto | California | 94304 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| University of San Diego Medical Center | San Diego | California | 92103 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| University of Miami Center for Liver Diseases | Miami | Florida | 33136 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| Indianapolis Gastroenterology Research Foundation | Indianapolis | Indiana | 46237 | — |
| Iowa Digestive Disease Center | Clive | Iowa | 50325 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 01125 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Minnesota Gastroenterology, PA | Saint Paul | Minnesota | 55114 | — |
| St. Louis University | St Louis | Missouri | 63104 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Duke Clinical Research Institute | Durham | North Carolina | 27710 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University Gastroenterology | Providence | Rhode Island | 02905 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| St. Luke Episcopal Hospital | Houston | Texas | 77030 | — |
| Alamo Medical Research | San Antonio | Texas | 78215 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| University of Virginia Health Center | Charlottesville | Virginia | 22908 | — |
| Liver Institute of Virginia | Newport News | Virginia | 23603 | — |
| Digestive and Liver Disease Specialists | Norfolk | Virginia | 23502 | — |
| Bon Secours Richmond Health System | Richmond | Virginia | 23226 | — |
| Virginia Commonwealth University Health System | Richmond | Virginia | 23298 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| University of Washington | Seattle | Washington | 98103 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 32 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01672853, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 22, 2019 · Synced Oct 28, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01672853 live on ClinicalTrials.gov.