Simtuzumab (SIM, GS-6624) in the Treatment of Cirrhosis Due to NASH
Public ClinicalTrials.gov record NCT01672879. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Dose-Ranging, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Safety and Efficacy of GS-6624, a Monoclonal Antibody Against Lysyl Oxidase-Like 2 (LOXL2), in Subjects With Compensated Cirrhosis Secondary to Non-Alcoholic Steatohepatitis (NASH)
Study identification
- NCT ID
- NCT01672879
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Gilead Sciences
- Industry
- Enrollment
- 259 participants
Conditions and interventions
Conditions
Interventions
- Placebo Biological
- SIM Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 28, 2012
- Primary completion
- Sep 25, 2016
- Completion
- Jan 2, 2017
- Last update posted
- Mar 26, 2019
2012 – 2017
United States locations
- U.S. sites
- 41
- U.S. states
- 25
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| Southern California Liver Centers | Coronado | California | 92118 | — |
| University of California, San Diego (UCSD) | San Diego | California | 92103 | — |
| University of California San Francisco (UCSF) | San Francisco | California | 94143 | — |
| University of Colorado, Denver | Aurora | Colorado | 80045 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Indiana University School of Medicine, Division of Gastroenterology/Hepatology | Indianapolis | Indiana | 46202 | — |
| Iowa Digestive Disease Center | Clive | Iowa | 50325 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Tulane University | New Orleans | Louisiana | 70112 | — |
| Mercy Medical Center | Baltimore | Maryland | 21202 | — |
| Walter Reed National Military Medical Center | Bethesda | Maryland | 20889 | — |
| Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| University of Mississippi Medical Center | Jackson | Michigan | 39216 | — |
| Minnnesota Gastroenterology, PA | Saint Paul | Minnesota | 55114 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63110 | — |
| State University Of New York at Buffalo | Buffalo | New York | 14203 | — |
| North Shore University Health System | Manhasset | New York | 11030 | — |
| New York University | New York | New York | 10016 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| University of Pennsylvania Hospital | Philadelphia | Pennsylvania | 19104 | — |
| University Gastroenterology | Providence | Rhode Island | 02905 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Methodist University Hospital | Memphis | Tennessee | 38104 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212 | — |
| Texas Clinical Research Institute | Arlington | Texas | 76012 | — |
| Brooke Army Medical Center | Fort Sam Houston | Texas | 78234 | — |
| St. Luke Episcopal Hospital | Houston | Texas | 77030 | — |
| Alamo Clinical Research Associates | San Antonio | Texas | 78215 | — |
| Intermountain Transplant Center | Murray | Utah | 84107 | — |
| University of Virginia Health Center | Charlottesville | Virginia | 22908 | — |
| Liver Institute of Virginia | Newport News | Virginia | 23602 | — |
| Digestive and Liver Disease Specialists | Norfolk | Virginia | 23502 | — |
| Bucheon St. Marys Hospital | Richmond | Virginia | 23226 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| University of Washington | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01672879, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 26, 2019 · Synced May 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01672879 live on ClinicalTrials.gov.