A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy
Public ClinicalTrials.gov record NCT01677754. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Investigate the Efficacy and Safety of RO4602522 Added to Background Alzheimer's Disease Therapy in Patients With Moderate Severity Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This Phase II, multicenter, randomized, double-blind, parallel-group, placebo-controlled study will evaluate the efficacy and safety of RO4602522 in participants with moderate severity Alzheimer's disease. Participants who are taking background therapy of acetylcholinesterase inhibitors (AChEI) alone or in combination with memantine for at least 4 months before screening will be randomized to receive either one of two doses of RO4602522 or placebo for 12 months.
Study identification
- NCT ID
- NCT01677754
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 542 participants
Conditions and interventions
Conditions
Interventions
- RO4602522 Drug
- Placebo Drug
- Donepezil Drug
- Memantine Drug
- Rivastigmine Drug
- Galantamine Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 24, 2012 (Actual)
- Primary completion
- Jun 12, 2015 (Actual)
- Completion
- Jun 12, 2015 (Actual)
- Last update posted
- May 30, 2017
2012 – 2015
United States locations
- U.S. sites
- 42
- U.S. states
- 18
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Research Center, Inc.;In-Patient Unit | Anaheim | California | 92801 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| Torrance Clinical Research | Lomita | California | 90717 | — |
| Artemis Institute for Clinical Research, LLC | San Diego | California | 92103 | — |
| Sharp Mesa Vista Hospital | San Diego | California | 92123 | — |
| San Francisco Clinical Research Center | San Francisco | California | 94109 | — |
| Neurological Research Inst | Santa Monica | California | 90025 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06510 | — |
| Research Center for Clinical Studies, Inc. | Norwalk | Connecticut | 06851 | — |
| Parkinson's Disease and Movement Disorders Center of Boca Raton | Boca Raton | Florida | 33486 | — |
| Meridien Research | Brooksville | Florida | 34601 | — |
| Brain Matters Research, Inc. | Delray Beach | Florida | 33445 | — |
| Neurologic Consultants, P.A. | Fort Lauderdale | Florida | 33308 | — |
| Galiz Research, LLC | Hialeah | Florida | 33016 | — |
| Miami Jewish Health Systems | Miami | Florida | 33137 | — |
| Medical Research Group of Central Florida | Orange City | Florida | 3273 | — |
| Compass Research East, LLC | Orlando | Florida | 32806 | — |
| Comprehensive Clinical Development, Inc.- St. Petersburg, FL | St. Petersburg | Florida | 33716 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Premiere Research Institute | West Palm Beach | Florida | 33407 | — |
| iResearch Atlanta | Decatur | Georgia | 30030 | — |
| NeuroStudies.net, LLC | Decatur | Georgia | 30033 | — |
| Alexian Brothers Neurosci Inst | Elk Grove Village | Illinois | 60007 | — |
| Louisiana Research Associates | New Orleans | Louisiana | 70114 | — |
| Booker, J. Gary, MD, APMC | Shreveport | Louisiana | 71104-2136 | — |
| Northern Michigan Neurology | Traverse City | Michigan | 49684 | — |
| Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| Millennium Psychiatric Associates, LLC | Creve Coeur | Missouri | 63141 | — |
| Memory Enhancement Center of America, Inc. | Eatontown | New Jersey | 07724 | — |
| Albuquerque Neuroscience Inc. | Albuquerque | New Mexico | 87109 | — |
| New York University Medical Center;Child Study Center | New York | New York | 10016 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10312 | — |
| Raleigh Neurology Associates | Raleigh | North Carolina | 27607-6520 | — |
| PMG Research of Winston-Salem, LLC | Winston-Salem | North Carolina | 27103 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Cutting Edge Research Group | Oklahoma City | Oklahoma | 73116 | — |
| The Clinical Trial Center, LLC | Jenkintown | Pennsylvania | 19046 | — |
| Radiant Research, Inc. | Wyomissing | Pennsylvania | 19610 | — |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02914 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Alzheimer's Research & Clinical Programs | Charleston | South Carolina | 29425 | — |
| University of North Texas Health Science Center | Fort Worth | Texas | 76107 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 100 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01677754, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 30, 2017 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01677754 live on ClinicalTrials.gov.