Efficacy and Safety of Brodalumab Compared With Placebo and Ustekinumab in Moderate to Severe Plaque Psoriasis Subjects
Public ClinicalTrials.gov record NCT01708629. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Study to Evaluate the Efficacy and Safety of Induction and Maintenance Regimens of Brodalumab Compared With Placebo and Ustekinumab in Subjects With Moderate to Severe Plaque Psoriasis: AMAGINE-3
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the safety and efficacy of brodalumab at two different doses compared with placebo in participants with moderate to severe plaque psoriasis. A second purpose of this study is to assess the safety and efficacy brodalumab at two different doses compared with ustekinumab in participants with moderate to severe plaque psoriasis. A third purpose of this study is to assess the safety and efficacy of 4 maintenance regimens of brodalumab.
Study identification
- NCT ID
- NCT01708629
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,881 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2012 (Type not available)
- Primary completion
- Aug 2014 (Actual)
- Completion
- Oct 2015 (Actual)
- Last update posted
- Jan 3, 2020
2012 – 2015
United States locations
- U.S. sites
- 74
- U.S. states
- 29
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35205 | — |
| Research Site | Mobile | Alabama | 36608 | — |
| Research Site | Phoenix | Arizona | 85023 | — |
| Research Site | Beverly Hills | California | 90212 | — |
| Research Site | Burbank | California | 91505 | — |
| Research Site | Encino | California | 91436 | — |
| Research Site | Fremont | California | 94538 | — |
| Research Site | Fullerton | California | 92835 | — |
| Research Site | Irvine | California | 92614 | — |
| Research Site | Los Angeles | California | 90036 | — |
| Research Site | Riverside | California | 92505 | — |
| Research Site | Sacramento | California | 95819 | — |
| Research Site | San Diego | California | 92103 | — |
| Research Site | San Diego | California | 92123 | — |
| Research Site | San Francisco | California | 94118 | — |
| Research Site | Denver | Colorado | 80220 | — |
| Research Site | Farmington | Connecticut | 06030 | — |
| Research Site | Trumbull | Connecticut | 06611 | — |
| Research Site | Boca Raton | Florida | 33486 | — |
| Research Site | Coral Gables | Florida | 33134 | — |
| Research Site | Hollywood | Florida | 33021 | — |
| Research Site | Jacksonville | Florida | 32204 | — |
| Research Site | Miami | Florida | 33144 | — |
| Research Site | Ocala | Florida | 34471 | — |
| Research Site | Tamarac | Florida | 33321 | — |
| Research Site | Alpharetta | Georgia | 30022 | — |
| Research Site | Atlanta | Georgia | 30327 | — |
| Research Site | Macon | Georgia | 31217 | — |
| Research Site | Boise | Idaho | 83704 | — |
| Research Site | Arlington Heights | Illinois | 60005 | — |
| Research Site | Champaign | Illinois | 61820 | — |
| Research Site | Maywood | Illinois | 60153 | — |
| Research Site | Normal | Illinois | 61761 | — |
| Research Site | Wheaton | Illinois | 60189 | — |
| Research Site | Indianapolis | Indiana | 46256 | — |
| Research Site | New Albany | Indiana | 47150 | — |
| Research Site | Overland Park | Kansas | 66202 | — |
| Research Site | Overland Park | Kansas | 66215 | — |
| Research Site | Louisville | Kentucky | 40217 | — |
| Research Site | Owensboro | Kentucky | 42303 | — |
| Research Site | Worcester | Massachusetts | 01605 | — |
| Research Site | Ann Arbor | Michigan | 48103 | — |
| Research Site | Clarkston | Michigan | 48346 | — |
| Research Site | Clinton Township | Michigan | 48038 | — |
| Research Site | Henderson | Nevada | 89074 | — |
| Research Site | Las Vegas | Nevada | 89144 | — |
| Research Site | East Windsor | New Jersey | 08520 | — |
| Research Site | Hoboken | New Jersey | 07030 | — |
| Research Site | Verona | New Jersey | 07044 | — |
| Research Site | New York | New York | 10016 | — |
| Research Site | Rochester | New York | 14623 | — |
| Research Site | The Bronx | New York | 10467 | — |
| Research Site | High Point | North Carolina | 27262 | — |
| Research Site | Cincinnati | Ohio | 45249 | — |
| Research Site | Cleveland | Ohio | 44106 | — |
| Research Site | Lake Oswego | Oregon | 97035 | — |
| Research Site | Portland | Oregon | 97210 | — |
| Research Site | Exton | Pennsylvania | 19341 | — |
| Research Site | Johnston | Rhode Island | 02919 | — |
| Research Site | Greer | South Carolina | 29650 | — |
| Research Site | Bartlett | Tennessee | 38134 | — |
| Research Site | Nashville | Tennessee | 37205 | — |
| Research Site | Bellaire | Texas | 77401 | — |
| Research Site | Dallas | Texas | 75230 | — |
| Research Site | Dallas | Texas | 75231 | — |
| Research Site | Houston | Texas | 77004 | — |
| Research Site | Houston | Texas | 77030 | — |
| Research Site | Houston | Texas | 77082 | — |
| Research Site | Webster | Texas | 77598 | — |
| Research Site | Salt Lake City | Utah | 84132 | — |
| Research Site | Norfolk | Virginia | 23507 | — |
| Research Site | Richmond | Virginia | 23294 | — |
| Research Site | Spokane | Washington | 99204 | — |
| Research Site | Clarksburg | West Virginia | 26301 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 83 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01708629, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 3, 2020 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01708629 live on ClinicalTrials.gov.