Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil
Public ClinicalTrials.gov record NCT01712074. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, 18-week, Placebo-controlled, Double-blind, Parallel Group Study Of The Safety And Efficacy Of Pf-05212377 (Sam-760) In Subjects With Mild-to-moderate Alzheimer's Disease With Existing Neuropsychiatric Symptoms On A Stable Daily Dose Of Donepezil
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate safety and efficacy of PF-05212377 in subjects with mild-to-moderate Alzheimer's Disease with existing neuropsychiatric symptoms on a stable dose of Donepezil. The 4-week run-in will minimize placebo effect. The 12-week treatment period is considered the minimum length necessary to reliably evaluate the effect PF-05212377 on cognition and and neuropsychiatric symptoms in this population. The 2-week washout will allow to monitor re-emergence of neuropsychiatric and cognitive symptoms.
Study identification
- NCT ID
- NCT01712074
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 186 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2012 (Type not available)
- Primary completion
- Sep 2015 (Actual)
- Completion
- Sep 2015 (Actual)
- Last update posted
- Mar 20, 2017
2012 – 2015
United States locations
- U.S. sites
- 40
- U.S. states
- 15
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| ATP Clinical Research, Inc | Costa Mesa | California | 92626 | — |
| Sun Valley Research Center | Imperial | California | 92251 | — |
| Desert Valley Research | Rancho Mirage | California | 92270 | — |
| RAA - Apex Aquisition, LLC | Santa Ana | California | 92705 | — |
| Geriatric and Adult Psychiatry LLC | Hamden | Connecticut | 06518 | — |
| Yale University | New Haven | Connecticut | 06510 | — |
| Yale-New Haven Hospital, Temple Radiology | New Haven | Connecticut | 06510 | — |
| Yale University School of Medicine, MRI Research Center (MRI) | New Haven | Connecticut | 06520 | — |
| Diagnostic Centers of America | Boynton Beach | Florida | 33437 | — |
| Meridien Research | Brooksville | Florida | 34601 | — |
| Quantum Laboratories | Deerfield Beach | Florida | 33064 | — |
| Brain Matters Research Inc | Delray Beach | Florida | 33445 | — |
| MD Clinical | Hallandale | Florida | 33009 | — |
| Compass Research LLC-North Clinic | Leesburg | Florida | 34748 | — |
| Medical Research Group of Central Florida | Orange City | Florida | 32763 | — |
| Premiere Research Institute | West Palm Beach | Florida | 33407 | — |
| Institute for Advanced Medical Research | Alpharetta | Georgia | 30005 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| Columbus Research & Wellness Institute, Inc. | Columbus | Georgia | 31904 | — |
| Lake Charles Clinical Trials | Lake Charles | Louisiana | 70629 | — |
| Michigan State University | East Lansing | Michigan | 48824 | — |
| Metro Imaging (Imaging only) | Creve Coeur | Missouri | 63141 | — |
| Millennium Psychiatric Associates, LLC | Creve Coeur | Missouri | 63141 | — |
| Eastside Comprehensive Medical Center, LLC | New York | New York | 10021 | — |
| University of Rochester Medical Center AD-CARE Program | University of Rochester Medical Center | Rochester | New York | 14620 | — |
| University of Rochester Medical Center (MRI Imaging Only) | Rochester | New York | 14642 | — |
| Behavioral Medical Research of Staten Island | Staten Island | New York | 10305 | — |
| The Ohio State University (administrative offices only) | Columbus | Ohio | 43212 | — |
| The Ohio State University - 2050 | Columbus | Ohio | 43221 | — |
| Keystone Clinical Studies, LLC | Norristown | Pennsylvania | 19403 | — |
| Roper Hospital (Imaging Only) | Charleston | South Carolina | 29401 | — |
| Roper St. Francis Healthcare | Charleston | South Carolina | 29401 | — |
| Roper St. Francis Pharmacy (IP Shipment/Storage) | Charleston | South Carolina | 29401 | — |
| Neurology Clinic, P.C. | Cordova | Tennessee | 38018 | — |
| Senior Adults Speciality Research Inc. | Austin | Texas | 78757 | — |
| Grayline Clinical Drug Trials | Wichita Falls | Texas | 76309 | — |
| Clinical Neuroscience Research Assoc. d/b/a The Memory Clinic | Bennington | Vermont | 05201 | — |
| Dean Foundation for Health, Research and Education | Middleton | Wisconsin | 53562 | — |
| Cary J. Kohlenberg, MD, dba, IPC Research | Waukesha | Wisconsin | 53188 | — |
| Merrill Hills Manor | Waukesha | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01712074, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 20, 2017 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01712074 live on ClinicalTrials.gov.