Efficacy and Safety of Inotersen in Familial Amyloid Polyneuropathy

ClinicalTrials.gov ID: NCT01737398

Public ClinicalTrials.gov record NCT01737398. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 6:07 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of ISIS 420915 in Patients With Familial Amyloid Polyneuropathy (NEURO-TTR Study)

Study identification

NCT ID: NCT01737398
Recruitment status: Completed
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Ionis Pharmaceuticals, Inc.; Industry
Enrollment: 173 participants

Conditions and interventions

Conditions

Interventions

Inotersen Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 82 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 14, 2013
Primary completion: Mar 2, 2017
Completion: Nov 6, 2017
Last update posted: Jul 16, 2019

2013 – 2017

United States locations

U.S. sites: 9
U.S. states: 8
U.S. cities: 8

Facility	City	State	ZIP	Site status
University of California, Irvine	Orange	California	92868	—
Indiana University School of Medicine	Indianapolis	Indiana	46202	—
Johns Hopkins University Bayview Medical Center	Baltimore	Maryland	21205	—
Boston University School of Medicine - Amyloid Treatment & Research Program	Boston	Massachusetts	02118	—
Mayo Clinic	Rochester	Minnesota	55905	—
Mount Sinai Medical Center	New York	New York	10029	—
Columbia University Medical Center - The Neurological Institute	New York	New York	10032	—
Oregon Health & Science University	Portland	Oregon	97239	—
Penn Presbyterian Medical Center	Philadelphia	Pennsylvania	19104	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT01737398, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 16, 2019 · Synced Jul 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT01737398 live on ClinicalTrials.gov.

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