Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC)
Public ClinicalTrials.gov record NCT01737814. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC): A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial of MST-188 (Purified Poloxamer 188) Injection in Subjects With Sickle Cell Disease Experiencing Vaso Occlusive Crisis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate whether MST-188 can reduce the duration of vaso-occlusive crisis (VOC) in subjects with sickle cell disease. The study will also evaluate whether MST-188 can reduce the frequency of rehospitalization of subjects due to a recurrence of VOC. Additionally, this study will compare the development of acute chest syndrome during VOC in subjects who receive MST-188 to those who do not receive MST-188.
Study identification
- NCT ID
- NCT01737814
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 388 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 4 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2013 (Type not available)
- Primary completion
- Feb 2016 (Actual)
- Completion
- Not listed
- Last update posted
- Oct 28, 2016
Started 2013
United States locations
- U.S. sites
- 50
- U.S. states
- 25
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of South Alabama | Mobile | Alabama | 36688 | — |
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | — |
| UCSF Benioff Children's Hospital | Oakland | California | 94609 | — |
| University of California Davis Health System | Sacramento | California | 95817 | — |
| Rady Children's Hosptial | San Diego | California | 92123 | — |
| Harbor-UCLA Medical Center | Torrence | California | 90502 | — |
| Al DuPont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Howard University | Washington D.C. | District of Columbia | 20060 | — |
| Children's Hospital of SouthWest Florida | Fort Myers | Florida | 33908 | — |
| Joe Dimaggio Children's Hospital | Hollywood | Florida | 33021 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Miami Children's Hospital | Miami | Florida | 33155 | — |
| All Children's Hospital | St. Petersburg | Florida | 33701 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Georgia Regents University | Augusta | Georgia | 30912 | — |
| Ann and Robert H. Lurie Children's Hospital of Chicago | Chicago | Illinois | 60611 | — |
| Children's Hospital at the University of Illinois | Chicago | Illinois | 60612 | — |
| Fort Wayne Lutheran Hospital | Fort Wayne | Indiana | 46804 | — |
| Riley Hospital for Children | Indianapolis | Indiana | 46202 | — |
| University of Iowa-Children's Hospital | Iowa City | Iowa | 52242 | — |
| University of Louisville/Kosair Children's Hospital | Louisville | Kentucky | 40202 | — |
| Our Lady of the Lake Children's Hospital | Baton Rouge | Louisiana | 70808 | — |
| Children's Hospital of New Orleans | New Orleans | Louisiana | 70118 | — |
| Johns Hopkins | Baltimore | Maryland | 21205 | — |
| The Herman and Walter Samuelson Children's Hospital at Sinai | Baltimore | Maryland | 21215 | — |
| Children's Hospital of Michigan-Wayne State University | Detroit | Michigan | 48201 | — |
| Hurley Research Center | Flint | Michigan | 48503 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Rutger's University | New Brunswick | New Jersey | 08903 | — |
| NY Methodist | Brooklyn | New York | 11215 | — |
| Cohen Children's Medical Center | New Hyde Park | New York | 11040 | — |
| Golisano Children's Hospital at URMC | Rochester | New York | 14642 | — |
| Bronx Lebanon Hospital | The Bronx | New York | 10457 | — |
| University of North Carolina-Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Rainbow Babies and Children's Hospital | Cleveland | Ohio | 44106 | — |
| Randall Children's Hospital | Portland | Oregon | 97227 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15224 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15232 | — |
| The Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| T.C. Thompson Children's Hospital | Chattanooga | Tennessee | 37403 | — |
| Cook's Children Hospital | Fort Worth | Texas | 76104 | — |
| Texas Children's Hospital | Houston | Texas | 77030 | — |
| University of Virginia Medical Center | Charlottsville | Virginia | 22908 | — |
| Children's Hospital of the King's Daughters | Norfolk | Virginia | 23507 | — |
| Children's Hospital of Richmond | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 22 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01737814, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 28, 2016 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01737814 live on ClinicalTrials.gov.