A Magnetic Resonance Imaging Study and Arthroscopic Biopsy Substudy in Subjects With Active Rheumatoid Arthritis Receiving VX-509, an Oral JAK3 Inhibitor
Public ClinicalTrials.gov record NCT01754935. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of VX-509 Using Magnetic Resonance Imaging and Arthroscopic Biopsies in Subjects With Active Rheumatoid Arthritis on Stable Disease-Modifying Antirheumatic Drugs
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The current study is designed to evaluate the safety and efficacy, including MRI imaging, across a range of VX-509 doses in subjects with active rheumatoid arthritis (RA) who have had an inadequate response to disease-modifying antirheumatic drugs (DMARDs).
Study identification
- NCT ID
- NCT01754935
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 43 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 2013 (Type not available)
- Primary completion
- Jan 2014 (Actual)
- Completion
- Feb 2014 (Actual)
- Last update posted
- May 19, 2015
2013 – 2014
United States locations
- U.S. sites
- 21
- U.S. states
- 14
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Vertex Investigational Site | Stanford | California | — | — |
| Vertex Investigational Site | Upland | California | — | — |
| Vertex Investigational Site | Fort Lauderdale | Florida | — | — |
| Vertex Investigational Site | Venice | Florida | — | — |
| Vertex Investigational Site | West Palm Beach | Florida | — | — |
| Vertex Investigational Site | Canton | Georgia | — | — |
| Vertex Investigational Site | Decatur | Georgia | — | — |
| Vertex Investigational Site | Kansas City | Kansas | — | — |
| Vertex Investigational Site | Elizabethtown | Kentucky | — | — |
| Vertex Investigational Site | Frederick | Maryland | — | — |
| Vertex Investigational Site | Lincoln | Nebraska | — | — |
| Vertex Investigational Site | Rochester | New York | — | — |
| Vertex Investigational Site | Greenboro | North Carolina | — | — |
| Vertex Investigational Site | Duncansville | Pennsylvania | — | — |
| Vertex Investigational Site | Charleston | South Carolina | — | — |
| Vertex Investigational Site | Memphis | Tennessee | — | — |
| Vertex Investigational Site | Katy | Texas | — | — |
| Vertex Investigational Site | San Antonio | Texas | — | — |
| Vertex Investigational Site | Webster | Texas | — | — |
| Vertex Investigational Site | Seattle | Washington | — | — |
| Vertex Investigational Site | Spokane | Washington | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 9 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01754935, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 19, 2015 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01754935 live on ClinicalTrials.gov.