Monoclonal Antibody Against PCSK9 to Reduce Elevated LDL-C in Subjects Currently Not Receiving Drug Therapy for Easing Lipid Levels-2
Public ClinicalTrials.gov record NCT01763827. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind, Randomized, Placebo and Ezetimibe-controlled, Multicenter Study to Evaluate Safety and Efficacy of Lipid Lowering Monotherapy With AMG 145 in Subjects With a 10-Year Framingham Risk Score of 10% or Less
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective was to evaluate the effect of 12 weeks of evolocumab subcutaneous (SC) monotherapy every 2 weeks (Q2W) and monthly (QM), compared with placebo and ezetimibe, on percent change from baseline in low-density lipoprotein cholesterol (LDL-C) in adults with a 10-year Framingham risk score of 10% or less.
Study identification
- NCT ID
- NCT01763827
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 615 participants
Conditions and interventions
Conditions
Interventions
- Evolocumab Biological
- Ezetimibe Drug
- Placebo to Evolocumab Biological
- Placebo to Ezetimibe Other
Biological · Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 21, 2013 (Actual)
- Primary completion
- Oct 10, 2013 (Actual)
- Completion
- Oct 29, 2013 (Actual)
- Last update posted
- Nov 8, 2022
2013
United States locations
- U.S. sites
- 47
- U.S. states
- 28
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35216 | — |
| Research Site | Chandler | Arizona | 85224 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Carmichael | California | 95608 | — |
| Research Site | Encinitas | California | 92024 | — |
| Research Site | San Diego | California | 92111 | — |
| Research Site | Tustin | California | 92780 | — |
| Research Site | Jacksonville | Florida | 32204 | — |
| Research Site | Jacksonville | Florida | 32216 | — |
| Research Site | Miami | Florida | 33144 | — |
| Research Site | Ponte Vedra | Florida | 32081 | — |
| Research Site | Sanford | Florida | 32771 | — |
| Research Site | Boise | Idaho | 83704 | — |
| Research Site | Chicago | Illinois | 60654 | — |
| Research Site | Indianapolis | Indiana | 46260 | — |
| Research Site | Overland Park | Kansas | 66202 | — |
| Research Site | Louisville | Kentucky | 40213 | — |
| Research Site | Bethesda | Maryland | 20817 | — |
| Research Site | Brockton | Massachusetts | 02301 | — |
| Research Site | Edina | Minnesota | 55435 | — |
| Research Site | Olive Branch | Mississippi | 38654 | — |
| Research Site | Las Vegas | Nevada | 89148 | — |
| Research Site | Endwell | New York | 13760 | — |
| Research Site | New Windsor | New York | 12553 | — |
| Research Site | Raleigh | North Carolina | 27609 | — |
| Research Site | Raleigh | North Carolina | 27612 | — |
| Research Site | Fargo | North Dakota | 58103 | — |
| Research Site | Akron | Ohio | 44311 | — |
| Research Site | Cincinnati | Ohio | 45212 | — |
| Research Site | Cincinnati | Ohio | 45236 | — |
| Research Site | Cincinnati | Ohio | 45246 | — |
| Research Site | Cleveland | Ohio | 44122 | — |
| Research Site | Norman | Oklahoma | 73069 | — |
| Research Site | Oklahoma City | Oklahoma | 73103 | — |
| Research Site | Duncansville | Pennsylvania | 16635 | — |
| Research Site | Anderson | South Carolina | 29621 | — |
| Research Site | Mt. Pleasant | South Carolina | 29464 | — |
| Research Site | Rapid City | South Dakota | 57702 | — |
| Research Site | Jackson | Tennessee | 38305 | — |
| Research Site | Boerne | Texas | 78006 | — |
| Research Site | Dallas | Texas | 75230 | — |
| Research Site | San Antonio | Texas | 78205 | — |
| Research Site | Salt Lake City | Utah | 84124 | — |
| Research Site | Norfolk | Virginia | 23502 | — |
| Research Site | Richmond | Virginia | 23294 | — |
| Research Site | Renton | Washington | 98057 | — |
| Research Site | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 36 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01763827, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 8, 2022 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01763827 live on ClinicalTrials.gov.