Study to Assess the Efficacy and Safety of Simtuzumab (GS-6624) in Adults With Idiopathic Pulmonary Fibrosis (IPF)
Public ClinicalTrials.gov record NCT01769196. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Assess the Efficacy and Safety of Simtuzumab (GS-6624) in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objectives of this study are to determine the effect of simtuzumab (GS-6624) on progression-free survival (PFS) as determined by either a categorical decline in forced vital capacity (FVC) or all-cause mortality, in all participants enrolled or in a subset of participants who are classified as lysyl oxidase-like-2 (LOXL2) high based on a prespecified level in serum at baseline.
Study identification
- NCT ID
- NCT01769196
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 544 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 45 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 30, 2013
- Primary completion
- Feb 22, 2016
- Completion
- Feb 22, 2016
- Last update posted
- May 29, 2017
2013 – 2016
United States locations
- U.S. sites
- 72
- U.S. states
- 30
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Pulmonary Specialists, Ltd. | Phoenix | Arizona | 85012 | — |
| Saint Joseph's Hospital and Medical Center | Phoenix | Arizona | 85103 | — |
| Arizona Pulmonary Specialists, Ltd. | Scottsdale | Arizona | 85258 | — |
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | — |
| The University of Arizona | Tucson | Arizona | 85724 | — |
| University of California San Diego | La Jolla | California | 92093 | — |
| David Geffen School of Medicine at University of California, Los Angeles | Los Angeles | California | 90024 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Sansum Clinic | Santa Barbara | California | 93105 | — |
| Stanford University Medical Center | Stanford | California | 94305 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06150 | — |
| Bay Area Chest Physicians | Clearwater | Florida | 33756 | — |
| University of Florida | Jacksonville | Florida | 32209 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Southeastern Lung Care | Decatur | Georgia | 30033 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Loess Hills Clinical Research Center | Council Bluffs | Iowa | 51503 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Kentuckiana Pulmonary Associates | Louisville | Kentucky | 40202 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Tulane University School of Medicine | New Orleans | Louisiana | 70112 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Tufts University School of Medicine | Boston | Massachusetts | 02111 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02120 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Massachusetts General Hospital | Boston | Massachusetts | — | — |
| Henry Ford Hospital | Detroit | Michigan | 48124 | — |
| University of Minnesota Medical Center | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| CardioPulmonary Associates | Chesterfield | Missouri | 63017 | — |
| Saint Luke's Midwest Pulmonary Consultants | Kansas City | Missouri | 64111 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 55905 | — |
| Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08903-0019 | — |
| Pulmonary and Allergy Associates, PA | Summit | New Jersey | 07901 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| Jamaica Hospital Medical Center | Jamaica | New York | 11418 | — |
| North Shore University Hospital | New Hyde Park | New York | 11040 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Columbia University | New York | New York | 10032 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| University of Rochester | Rochester | New York | 14620 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45267 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43221 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| The Oregon Clinic, PC | Portland | Oregon | 97220 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Hospital, Temple Lung Center | Philadelphia | Pennsylvania | 19140 | — |
| University of Pittsburgh Presbyterian - Montefiore | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84108 | — |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Providence Everett Medical Center | Everett | Washington | 98201 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| Froedtert Hospital and Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 103 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01769196, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 29, 2017 · Synced Sep 29, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01769196 live on ClinicalTrials.gov.