Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients
Public ClinicalTrials.gov record NCT01769768. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase Ib, Multi-center, Two Parallel Group, Open-label, Drug-drug Interaction Study to Assess the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients With Advanced Solid Tumors
Study identification
- NCT ID
- NCT01769768
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 114 participants
Conditions and interventions
Conditions
Interventions
- Bupropion Drug
- LDE225 Drug
- Wafarin Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 31, 2013
- Primary completion
- Jul 31, 2016
- Completion
- Jul 31, 2016
- Last update posted
- Dec 18, 2020
2013 – 2016
United States locations
- U.S. sites
- 13
- U.S. states
- 10
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope National Medical Center Oncology | Duarte | California | 91010 | — |
| University of Kansas Medical Center CBYM338B2203 | Kansas City | Kansas | 66160 | — |
| Massachusetts General Hospital Dana-Farber Cancer Institute | Boston | Massachusetts | 02114 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock Med Ctr | Lebanon | New Hampshire | 03756 | — |
| Hackensack University Medical Center Dept.of HackensackUniv.MedCtr. | Hackensack | New Jersey | 07601 | — |
| University of Pennsylvania--Abramson Cancer Center Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111-2497 | — |
| University of Pittsburgh Cancer Institute UPMC Cancer Pavilion | Pittsburgh | Pennsylvania | 15232 | — |
| Medical University of South Carolina Dept.of Neurosciences/MS Ctr. | Charleston | South Carolina | 29425 | — |
| Cancer Centers of the Carolinas SC | Greenville | South Carolina | 29605 | — |
| Utah Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| University of Utah / Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01769768, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 18, 2020 · Synced May 12, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01769768 live on ClinicalTrials.gov.