COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure
Public ClinicalTrials.gov record NCT01786512. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind, Randomized, Placebo-controlled, Multicenter, Dose Escalation Study to Select and Evaluate an Oral Modified Release Formulation of Omecamtiv Mecarbil in Subjects With Heart Failure and Left Ventricular Systolic Dysfunction
Study identification
- NCT ID
- NCT01786512
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Cytokinetics
- Industry
- Enrollment
- 544 participants
Conditions and interventions
Conditions
Interventions
- Omecamtiv Mecarbil Matrix F1 Formulation Drug
- Omecamtiv Mecarbil Matrix F2 Formulation Drug
- Omecamtiv Mecarbil Swellable Core Technology F2 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 25, 2013
- Primary completion
- Jul 21, 2015
- Completion
- Aug 18, 2015
- Last update posted
- Aug 11, 2021
2013 – 2015
United States locations
- U.S. sites
- 38
- U.S. states
- 22
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Mobile | Alabama | 36608 | — |
| Research Site | Costa Mesa | California | 92626 | — |
| Research Site | Fresno | California | 93721 | — |
| Research Site | Inglewood | California | 90301 | — |
| Research Site | La Jolla | California | 92037 | — |
| Research Site | Los Angeles | California | 90033 | — |
| Research Site | Thousand Oaks | California | 91360 | — |
| Research Site | Tustin | California | 92780 | — |
| Research Site | Danbury | Connecticut | 06810 | — |
| Research Site | Newark | Delaware | 19718 | — |
| Research Site | Atlantis | Florida | 33462 | — |
| Research Site | Aventura | Florida | 33180 | — |
| Research Site | Clearwater | Florida | 33756 | — |
| Research Site | Miami | Florida | 33136 | — |
| Research Site | Tampa | Florida | 33606 | — |
| Research Site | Atlanta | Georgia | 30322 | — |
| Research Site | Macon | Georgia | 31201 | — |
| Research Site | Chicago | Illinois | 60612 | — |
| Research Site | Auburn | Maine | 04210 | — |
| Research Site | Baltimore | Maryland | 21201 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Petoskey | Michigan | 49770 | — |
| Research Site | Minneapolis | Minnesota | 55415 | — |
| Research Site | Minneapolis | Minnesota | 55417 | — |
| Research Site | St Louis | Missouri | 63110 | — |
| Research Site | Las Vegas | Nevada | 89128 | — |
| Research Site | Cortlandt Manor | New York | 10567 | — |
| Research Site | The Bronx | New York | 10467 | — |
| Research Site | Chapel Hill | North Carolina | 27599 | — |
| Research Site | Durham | North Carolina | 27705 | — |
| Research Site | Oklahoma City | Oklahoma | 73120 | — |
| Research Site | Portland | Oregon | 97239 | — |
| Research Site | Greenville | South Carolina | 29605 | — |
| Research Site | Nashville | Tennessee | 37232-8802 | — |
| Research Site | Tullahoma | Tennessee | 37388 | — |
| Research Site | Houston | Texas | 77030 | — |
| Research Site | Seattle | Washington | 98195 | — |
| Research Site | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 63 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01786512, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 11, 2021 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01786512 live on ClinicalTrials.gov.