Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function
Public ClinicalTrials.gov record NCT01812447. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Randomized, Controlled Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Spiration® Valve System for the Single Lobe Treatment of Severe Emphysema
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
EMPROVE is a multicenter, prospective, randomized, controlled study designed to evaluate the safety and long-term effectiveness of the Spiration Valve System in patients with emphysema. Patients appropriate for the EMPROVE study are those who are currently on medical treatment but still symptomatic. EMPROVE also accepts α-1 antitrypsin deficiency patients.
Study identification
- NCT ID
- NCT01812447
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 172 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 2013 (Actual)
- Primary completion
- Nov 2017 (Actual)
- Completion
- Aug 2022 (Actual)
- Last update posted
- May 31, 2024
2013 – 2022
United States locations
- U.S. sites
- 32
- U.S. states
- 21
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sparks Regional Medical Center | Fort Smith | Arkansas | 72901 | — |
| Kaiser Permanente Riverside Medical Center | Riverside | California | 92505 | — |
| University of California San Diego | San Diego | California | 92103 | — |
| California Pacific Medical Center | San Francisco | California | 94115 | — |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32216 | — |
| Miami VA Healthcare System | Miami | Florida | 33125 | — |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| University of Chicago | Chicago | Illinois | 60561 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Louisiana State University Hospital | Shreveport | Louisiana | 71130 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Lahey Clinic | Burlington | Massachusetts | 01805 | — |
| Beaumont Botsford Hospital (DCRC) | Farmington Hills | Michigan | 48336 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| Cornell NYPH | New York | New York | 10065 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28203 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| Kaiser Permanente Northwest Medical Center | Clackamas | Oregon | 97015 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212 | — |
| UT Southwestern Medical Center at Dallas | Dallas | Texas | 75235 | — |
| Michael DeBakey VA Medical Center | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Fletcher Allen Medical Center | Burlington | Vermont | 05401 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01812447, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 31, 2024 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01812447 live on ClinicalTrials.gov.