GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound
Public ClinicalTrials.gov record NCT01813422. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind, Randomized, Multi-center, Placebo-controlled, Parallel-group Study to Determine the Effects of Evolocumab (AMG 145) Treatment on Atherosclerotic Disease Burden as Measured by Intravascular Ultrasound in Subjects Undergoing Coronary Catheterization
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate whether low-density lipoprotein (LDL-C) lowering with evolocumab (AMG 145) results in greater change from baseline in percent atheroma volume (PAV) at week 78 than placebo in adults with coronary artery disease taking lipid lowering therapy.
Study identification
- NCT ID
- NCT01813422
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 970 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 18, 2013 (Actual)
- Primary completion
- Jul 12, 2016 (Actual)
- Completion
- Jul 29, 2016 (Actual)
- Last update posted
- Feb 20, 2019
2013 – 2016
United States locations
- U.S. sites
- 59
- U.S. states
- 25
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Huntsville | Alabama | 35801 | — |
| Research Site | Mobile | Alabama | 36608 | — |
| Research Site | Little Rock | Arkansas | 72211 | — |
| Research Site | La Jolla | California | 92037 | — |
| Research Site | La Jolla | California | 92093-0960 | — |
| Research Site | Long Beach | California | 90822 | — |
| Research Site | Newport Beach | California | 92663 | — |
| Research Site | Orange | California | 92868 | — |
| Research Site | San Diego | California | 92161 | — |
| Research Site | Santa Monica | California | 90404 | — |
| Research Site | Torrance | California | 90502 | — |
| Research Site | Washington D.C. | District of Columbia | 20010 | — |
| Research Site | Atlantis | Florida | 33462 | — |
| Research Site | Clearwater | Florida | 33756 | — |
| Research Site | Jacksonville | Florida | 32209 | — |
| Research Site | Jacksonville | Florida | 32216 | — |
| Research Site | Melbourne | Florida | 32901 | — |
| Research Site | Safety Harbor | Florida | 34695 | — |
| Research Site | Atlanta | Georgia | 30342 | — |
| Research Site | Hammond | Indiana | 46320 | — |
| Research Site | Valparaiso | Indiana | 46383 | — |
| Research Site | Lexington | Kentucky | 40536 | — |
| Research Site | Louisville | Kentucky | 40205 | — |
| Research Site | Covington | Louisiana | 70433 | — |
| Research Site | Bethesda | Maryland | 20814 | — |
| Research Site | Columbia | Maryland | 21044 | — |
| Research Site | Ann Arbor | Michigan | 48109 | — |
| Research Site | Bay City | Michigan | 48708 | — |
| Research Site | Grand Rapids | Michigan | 49503 | — |
| Research Site | Marquette | Michigan | 49855 | — |
| Research Site | Midland | Michigan | 48670 | — |
| Research Site | Petoskey | Michigan | 49770 | — |
| Research Site | Saginaw | Michigan | 48601 | — |
| Research Site | Duluth | Minnesota | 55805 | — |
| Research Site | Minneapolis | Minnesota | 55407 | — |
| Research Site | Saint Cloud | Minnesota | 56303 | — |
| Research Site | Saint Paul | Minnesota | 55102 | — |
| Research Site | Columbia | Missouri | 65212 | — |
| Research Site | Missoula | Montana | 59802 | — |
| Research Site | Omaha | Nebraska | 68198 | — |
| Research Site | Ridgewood | New Jersey | 07450 | — |
| Research Site | Buffalo | New York | 14215 | — |
| Research Site | Johnson City | New York | 13790 | — |
| Research Site | Charlotte | North Carolina | 28204 | — |
| Research Site | Fargo | North Dakota | 58122 | — |
| Research Site | Canton | Ohio | 44710 | — |
| Research Site | Elyria | Ohio | 44035 | — |
| Research Site | Toledo | Ohio | 43614 | — |
| Research Site | Oklahoma City | Oklahoma | 73104 | — |
| Research Site | Tulsa | Oklahoma | 74104 | — |
| Research Site | Hillsboro | Oregon | 97123 | — |
| Research Site | Springfield | Oregon | 97477 | — |
| Research Site | Doylestown | Pennsylvania | 18901 | — |
| Research Site | Hershey | Pennsylvania | 17033 | — |
| Research Site | Oak Ridge | Tennessee | 37830 | — |
| Research Site | Amarillo | Texas | 79106 | — |
| Research Site | Dallas | Texas | 75216 | — |
| Research Site | San Antonio | Texas | 78229 | — |
| Research Site | Wichita Falls | Texas | 76301 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 167 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01813422, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 20, 2019 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01813422 live on ClinicalTrials.gov.