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Terminated Phase 2 Interventional Results available

Afatinib After Chemoradiation and Surgery in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck at High-Risk of Recurrence

ClinicalTrials.gov ID: NCT01824823

Public ClinicalTrials.gov record NCT01824823. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 19, 2026, 4:45 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Placebo Controlled Phase II Trial of Afatinib (BIBW2992) as Adjuvant Therapy Following Chemoradiation in Patients With Head and Neck Squamous Cell Carcinoma at High Risk of Recurrence

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized phase II trial studies how well giving afatinib after chemoradiation and surgery works in treating patients with stage III-IV squamous cell carcinoma of the head and neck at high-risk of recurrence. Afatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Study identification

NCT ID
NCT01824823
Recruitment status
Terminated
Study type
Interventional
Phase
Phase 2
Enrollment
3 participants

Conditions and interventions

Interventions

Drug · Other

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 30, 2014 (Actual)
Primary completion
Dec 13, 2015 (Actual)
Completion
Dec 2020 (Actual)
Last update posted
Jun 28, 2023

2014 – 2020

United States locations

U.S. sites
272
U.S. states
32
U.S. cities
189
Facility City State ZIP Site status
Alaska Breast Care and Surgery LLC Anchorage Alaska 99508 —
Alaska Women's Cancer Care Anchorage Alaska 99508 —
Anchorage Oncology Centre Anchorage Alaska 99508 —
Katmai Oncology Group Anchorage Alaska 99508 —
Providence Alaska Medical Center Anchorage Alaska 99508 —
Veteran's Administration Medical Center Little Rock Arkansas 72205 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
Saint Francis Hospital and Medical Center Hartford Connecticut 06105 —
Beebe Medical Center Lewes Delaware 19958 —
Christiana Gynecologic Oncology LLC Newark Delaware 19713 —
Delaware Clinical and Laboratory Physicians PA Newark Delaware 19713 —
Helen F Graham Cancer Center Newark Delaware 19713 —
Medical Oncology Hematology Consultants PA Newark Delaware 19713 —
Regional Hematology and Oncology PA Newark Delaware 19713 —
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 —
Beebe Health Campus Rehoboth Beach Delaware 19971 —
Nanticoke Memorial Hospital Seaford Delaware 19973 —
Christiana Care Health System-Wilmington Hospital Wilmington Delaware 19801 —
Emory University/Winship Cancer Institute Atlanta Georgia 30322 —
Medical Center of Central Georgia Macon Georgia 31208 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Kootenai Medical Center Coeur d'Alene Idaho 83814 —
Saint Joseph Regional Medical Center Lewiston Idaho 83501 —
Kootenai Cancer Center Post Falls Idaho 83854 —
Kootenai Cancer Sandpoint Idaho 83864 —
Memorial Hospital of Carbondale Carbondale Illinois 62902 —
Centralia Oncology Clinic Centralia Illinois 62801 —
John H Stroger Jr Hospital of Cook County Chicago Illinois 60612-3785 —
University of Illinois Chicago Illinois 60612 —
Saint Joseph Hospital Chicago Illinois 60657 —
Cancer Care Center of Decatur Decatur Illinois 62526 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Crossroads Cancer Center Effingham Illinois 62401 —
Hinsdale Hematology Oncology Associates Incorporated Hinsdale Illinois 60521 —
Garneau, Stewart C MD (UIA Investigator) Moline Illinois 61265 —
Porubcin, Michael MD (UIA Investigator) Moline Illinois 61265 —
Spector, David MD (UIA Investigator) Moline Illinois 61265 —
Trinity Medical Center Moline Illinois 61265 —
Good Samaritan Regional Health Center Mount Vernon Illinois 62864 —
Memorial Medical Center Springfield Illinois 62781-0001 —
Mary Greeley Medical Center Ames Iowa 50010 —
McFarland Clinic PC-William R Bliss Cancer Center Ames Iowa 50010 —
Constantinou, Costas L MD (UIA Investigator) Bettendorf Iowa 52722 —
McFarland Clinic PC-Boone Boone Iowa 50036 —
Medical Oncology and Hematology Associates-West Des Moines Clive Iowa 50325 —
Mercy Cancer Center-West Lakes Clive Iowa 50325 —
Iowa Methodist Medical Center Des Moines Iowa 50309 —
Iowa Oncology Research Association CCOP Des Moines Iowa 50309 —
Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa 50309 —
Medical Oncology and Hematology Associates-Laurel Des Moines Iowa 50314 —
Mercy Medical Center - Des Moines Des Moines Iowa 50314 —
Iowa Lutheran Hospital Des Moines Iowa 50316 —
McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa 50501 —
McFarland Clinic PC-Jefferson Jefferson Iowa 50129 —
McFarland Clinic PC-Marshalltown Marshalltown Iowa 50158 —
Siouxland Hematology Oncology Associates Sioux City Iowa 51101 —
Mercy Medical Center-Sioux City Sioux City Iowa 51104 —
Saint Luke's Regional Medical Center Sioux City Iowa 51104 —
Methodist West Hospital West Des Moines Iowa 50266-7700 —
Mercy Medical Center-West Lakes West Des Moines Iowa 50266 —
Cancer Center of Kansas - Chanute Chanute Kansas 66720 —
Cancer Center of Kansas - Dodge City Dodge City Kansas 67801 —
Cancer Center of Kansas - El Dorado El Dorado Kansas 67042 —
Cancer Center of Kansas - Fort Scott Fort Scott Kansas 66701 —
Cancer Center of Kansas-Independence Independence Kansas 67301 —
Cancer Center of Kansas-Kingman Kingman Kansas 67068 —
Lawrence Memorial Hospital Lawrence Kansas 66044 —
Cancer Center of Kansas-Liberal Liberal Kansas 67901 —
Cancer Center of Kansas-Manhattan Manhattan Kansas 66502 —
Cancer Center of Kansas - McPherson McPherson Kansas 67460 —
Cancer Center of Kansas - Newton Newton Kansas 67114 —
Cancer Center of Kansas - Parsons Parsons Kansas 67357 —
Cancer Center of Kansas - Pratt Pratt Kansas 67124 —
Cancer Center of Kansas - Salina Salina Kansas 67401 —
Cancer Center of Kansas - Wellington Wellington Kansas 67152 —
Associates In Womens Health Wichita Kansas 67208 —
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas 67208 —
Cancer Center of Kansas - Main Office Wichita Kansas 67214 —
Via Christi Regional Medical Center Wichita Kansas 67214 —
Wichita CCOP Wichita Kansas 67214 —
Cancer Center of Kansas - Winfield Winfield Kansas 67156 —
Harold Alfond Center for Cancer Care Augusta Maine 04330 —
Eastern Maine Medical Center Bangor Maine 04401 —
Penobscot Bay Medical Center Rockport Maine 04856 —
Greater Baltimore Medical Center Baltimore Maryland 21204 —
Bixby Medical Center Adrian Michigan 49221 —
Hickman Cancer Center Adrian Michigan 49221 —
Saint Joseph Mercy Hospital Ann Arbor Michigan 48106-0995 —
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor Michigan 48106 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Spectrum Health Big Rapids Hospital Big Rapids Michigan 49307 —
Oakwood Hospital and Medical Center Dearborn Michigan 48124 —
Saint John Hospital and Medical Center Detroit Michigan 48236 —
Hurley Medical Center Flint Michigan 48502 —
Genesys Hurley Cancer Institute Flint Michigan 48503 —
Grand Rapids Clinical Oncology Program Grand Rapids Michigan 49503 —
Mercy Health Saint Mary's Grand Rapids Michigan 49503 —
Spectrum Health at Butterworth Campus Grand Rapids Michigan 49503 —
Allegiance Health Jackson Michigan 49201 —
Borgess Medical Center Kalamazoo Michigan 49001 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Sparrow Hospital Lansing Michigan 48912 —
Saint Mary Mercy Hospital Livonia Michigan 48154 —
Community Cancer Center of Monroe Monroe Michigan 48162 —
Mercy Memorial Hospital Monroe Michigan 48162 —
Mercy Health Mercy Campus Muskegon Michigan 49444 —
Lakeland Community Hospital Niles Michigan 49120 —
Saint Joseph Mercy Oakland Pontiac Michigan 48341-2985 —
Saint Joseph Mercy Port Huron Port Huron Michigan 48060 —
Spectrum Health Reed City Hospital Reed City Michigan 49677 —
Saint Mary's of Michigan Saginaw Michigan 48601 —
Lakeland Hospital Saint Joseph Michigan 49085 —
Marie Yeager Cancer Center Saint Joseph Michigan 49085 —
Munson Medical Center Traverse City Michigan 49684 —
Saint John Macomb-Oakland Hospital Warren Michigan 48093 —
Fairview Ridges Hospital Burnsville Minnesota 55337 —
Mercy Hospital Coon Rapids Minnesota 55433 —
Fairview-Southdale Hospital Edina Minnesota 55435 —
Unity Hospital Fridley Minnesota 55432 —
Hutchinson Area Health Care Hutchinson Minnesota 55350 —
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109 —
Saint John's Hospital - Healtheast Maplewood Minnesota 55109 —
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
Health Partners Inc Minneapolis Minnesota 55454 —
New Ulm Medical Center New Ulm Minnesota 56073 —
North Memorial Medical Health Center Robbinsdale Minnesota 55422 —
Metro-Minnesota CCOP Saint Louis Park Minnesota 55416 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
Regions Hospital Saint Paul Minnesota 55101 —
United Hospital Saint Paul Minnesota 55102 —
Saint Francis Regional Medical Center Shakopee Minnesota 55379 —
Lakeview Hospital Stillwater Minnesota 55082 —
Ridgeview Medical Center Waconia Minnesota 55387 —
Rice Memorial Hospital Willmar Minnesota 56201 —
Minnesota Oncology and Hematology PA-Woodbury Woodbury Minnesota 55125 —
University of Mississippi Medical Center Jackson Mississippi 39216 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Phelps County Regional Medical Center Rolla Missouri 65401 —
Saint John's Clinic-Rolla-Cancer and Hematology Rolla Missouri 65401 —
Mercy Hospital Springfield Springfield Missouri 65804 —
Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield Springfield Missouri 65804 —
CoxHealth South Hospital Springfield Missouri 65807 —
Saint John's Mercy Medical Center St Louis Missouri 63141 —
Montana Cancer Consortium CCOP Billings Montana 59101 —
Saint Vincent Healthcare Billings Montana 59101 —
Billings Clinic Billings Montana 59107-7000 —
Bozeman Deaconess Hospital Bozeman Montana 59715 —
Saint James Community Hospital and Cancer Treatment Center Butte Montana 59701 —
Benefis Healthcare- Sletten Cancer Institute Great Falls Montana 59405 —
Saint Peter's Community Hospital Helena Montana 59601 —
Kalispell Regional Medical Center Kalispell Montana 59901 —
Community Medical Hospital Missoula Montana 59801 —
Saint Patrick Hospital - Community Hospital Missoula Montana 59802 —
Nebraska Hematology and Oncology Lincoln Nebraska 68506 —
Nebraska Cancer Research Center Lincoln Nebraska 68510 —
Missouri Valley Cancer Consortium Omaha Nebraska 68106 —
Nebraska Methodist Hospital Omaha Nebraska 68114 —
Alegent Health Immanuel Medical Center Omaha Nebraska 68122 —
Alegent Health Bergan Mercy Medical Center Omaha Nebraska 68124 —
Oncology Hematology West Omaha Nebraska 68124 —
Alegent Health Lakeside Hospital Omaha Nebraska 68130 —
Oncology Hematology West PC Omaha Nebraska 68130 —
Urology Cancer Center PC Omaha Nebraska 68130 —
Creighton University Medical Center Omaha Nebraska 68131 —
New York Oncology Hematology PC - Albany Albany New York 12206 —
New York Oncology Hematology PC -Albany Medical Center Albany New York 12208 —
New York Oncology Hematology PC-Hudson Hudson New York 12534 —
New York Oncology Hematology PC - Latham Latham New York 12110 —
Orange Regional Medical Center Middletown New York 10940 —
Albert Einstein College of Medicine The Bronx New York 10461 —
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 —
Montefiore Medical Center - Moses Campus The Bronx New York 10467-2490 —
New York Oncology Hematology PC - Troy Troy New York 12180 —
Randolph Hospital Asheboro North Carolina 27203 —
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328 —
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534 —
Wayne Memorial Hospital Goldsboro North Carolina 27534 —
Cone Health Cancer Center Greensboro North Carolina 27403 —
Margaret R Pardee Memorial Hospital Hendersonville North Carolina 28791 —
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546 —
Kinston Medical Specialists PA Kinston North Carolina 28501 —
Annie Penn Memorial Hospital Reidsville North Carolina 27320 —
Southeastern Medical Oncology Center-Wilson Wilson North Carolina 27893 —
Akron General Medical Center Akron Ohio 44307 —
Toledo Clinic Cancer Centers-Bowling Green Bowling Green Ohio 43402 —
University of Cincinnati Cincinnati Ohio 45267 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Saint Rita's Medical Center Lima Ohio 45801 —
Lima Memorial Hospital Lima Ohio 45804 —
Toledo Clinic Cancer Centers-Maumee Maumee Ohio 43537 —
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee Ohio 43537 —
Saint Charles Hospital Oregon Ohio 43616 —
Toledo Clinic Cancer Centers-Oregon Oregon Ohio 43616 —
Flower Hospital Sylvania Ohio 43560 —
Mercy Hospital of Tiffin Tiffin Ohio 44883 —
The Toledo Hospital/Toledo Children's Hospital Toledo Ohio 43606 —
Saint Vincent Mercy Medical Center Toledo Ohio 43608 —
University of Toledo Toledo Ohio 43614 —
Toledo Community Hospital Oncology Program CCOP Toledo Ohio 43617 —
Mercy Saint Anne Hospital Toledo Ohio 43623 —
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623 —
Fulton County Health Center Wauseon Ohio 43567 —
University Pointe West Chester Ohio 45069 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Tulsa Cancer Institute Tulsa Oklahoma 74146 —
Clackamas Radiation Oncology Center Clackamas Oregon 97015 —
Providence Milwaukie Hospital Milwaukie Oregon 97222 —
Providence Newberg Medical Center Newberg Oregon 97132 —
Providence Willamette Falls Medical Center Oregon City Oregon 97045 —
Providence Portland Medical Center Portland Oregon 97213 —
Western Oncology Research Consortium Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Geisinger Medical Center Danville Pennsylvania 17822 —
Adams Cancer Center Gettysburg Pennsylvania 17325 —
Cherry Tree Cancer Center Hanover Pennsylvania 17331 —
Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania 18201 —
Geisinger Medical Oncology at Evangelical Community Hospital Lewisburg Pennsylvania 17837 —
Lewistown Hospital Lewistown Pennsylvania 17044 —
Pottstown Memorial Medical Center Pottstown Pennsylvania 19464 —
Geisinger Medical Oncology-Pottsville Pottsville Pennsylvania 17901 —
Geisinger Medical Group State College Pennsylvania 16801 —
Geisinger Wyoming Valley Wilkes-Barre Pennsylvania 18711 —
WellSpan Health-York Hospital York Pennsylvania 17405 —
Greenville Health System Cancer Institute-Easley Easley South Carolina 29640 —
Greenville Health System Cancer Institute-Andrews Greenville South Carolina 29605 —
Greenville Health System Cancer Institute-Butternut Greenville South Carolina 29605 —
Greenville Health System Cancer Institute-Faris Greenville South Carolina 29605 —
Greenville Memorial Hospital Greenville South Carolina 29605 —
Greenville Health System Cancer Institute-Eastside Greenville South Carolina 29615 —
Greenville Health System Cancer Institute-Greer Greer South Carolina 29650 —
Greenville Health System Cancer Institute-Seneca Seneca South Carolina 29672 —
Greenville Health System Cancer Institute-Spartanburg Spartanburg South Carolina 29307 —
Wellmont Bristol Regional Medical Center Bristol Tennessee 37620 —
Wellmont Medical Associates Oncology and Hematology-Johnson City Johnson City Tennessee 37604 —
Wellmont Holston Valley Hospital and Medical Center Kingsport Tennessee 37660 —
Wellmont Medical Associates Oncology and Hematology-Kingsport Kingsport Tennessee 37660 —
Thompson Cancer Survival Center Knoxville Tennessee 37916 —
Meharry Medical College Nashville Tennessee 37208 —
University Medical Center Brackenridge Austin Texas 78701 —
Fredericksburg Oncology Inc Fredericksburg Virginia 22401 —
Southwest VA Regional Cancer Center Norton Virginia 24273 —
Auburn Regional Medical Center Auburn Washington 98001 —
Overlake Hospital Medical Center Bellevue Washington 98004 —
Providence Regional Cancer System-Centralia Centralia Washington 98531 —
Providence Regional Cancer Partnership Everett Washington 98201 —
Saint Francis Hospital Federal Way Washington 98003 —
Providence Regional Cancer System-Lacey Lacey Washington 98503 —
Saint Clare Hospital Lakewood Washington 98499 —
Saint John Medical Center Longview Washington 98632 —
Providence - Saint Peter Hospital Olympia Washington 98506-5166 —
Capital Medical Center Olympia Washington 98507 —
Good Samaritan Community Hospital Puyallup Washington 98372 —
Allenmore Hospital Tacoma Washington 98405 —
Northwest CCOP Tacoma Washington 98405 —
Northwest Medical Specialties PLLC Tacoma Washington 98405 —
Saint Joseph Medical Center Tacoma Washington 98405 —
Multicare Health System Tacoma Washington 98415 —
PeaceHealth Southwest Medical Center Vancouver Washington 98664 —
West Virginia University Charleston Charleston West Virginia 25304 —
West Virginia University Healthcare Morgantown West Virginia 26506 —
Langlade Hospital and Cancer Center Antigo Wisconsin 54409 —
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 —
Froedtert and the Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017 —
Aspirus Regional Cancer Center Wausau Wisconsin 54401 —
Riverview Hospital Wisconsin Rapids Wisconsin 54494 —
Rocky Mountain Oncology Casper Wyoming 82609 —
Big Horn Basin Cancer Center Cody Wyoming 82414 —
Billings Clinic-Cody Cody Wyoming 82414 —
Welch Cancer Center Sheridan Wyoming 82801 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT01824823, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jun 28, 2023 · Synced Oct 19, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT01824823 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →