ClinicalTrials.gov record
Efficacy and Safety of PT003, PT005, and PT001 in Subjects With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD); (PINNACLE 1)
ClinicalTrials.gov ID: NCT01854645
Public ClinicalTrials.gov record NCT01854645. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double Blind, Chronic Dosing, Placebo-Controlled, Parallel Group, Multi Center Study to Assess the Efficacy and Safety of PT003, PT005, and PT001 in Subjects With Moderate to Very Severe COPD, Compared With Placebo and Spiriva® Handihaler® (Tiotropium Bromide 18 µg Open-Label) as an Active Control
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The overall objective of this study is to assess the efficacy and safety of treatment with PT003 (GFF MDI), PT005 (FF MDI), PT001 (GP MDI), and open-label tiotropium bromide inhalation powder compared with each other and Placebo MDI over 24 weeks in subjects with moderate to very severe COPD.
Study identification
- NCT ID
- NCT01854645
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,103 participants
Conditions and interventions
Conditions
Interventions
- GFF MDI Drug
- GP MDI Drug
- FF MDI Drug
- Open-label tiotropium bromide inhalation powder (Spiriva® Handihaler®) Drug
- Placebo MDI Drug
Drug
Eligibility (public fields only)
- Age range
- 40 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2013 (Type not available)
- Primary completion
- Feb 2015 (Actual)
- Completion
- Feb 2015 (Actual)
- Last update posted
- Mar 28, 2017
2013 – 2015
United States locations
- U.S. sites
- 121
- U.S. states
- 38
- U.S. cities
- 121
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pearl Investigative Site | Andalusia | Alabama | — | — |
| Pearl Investigative Site | Anniston | Alabama | — | — |
| Pearl Investigative Site | Athens | Alabama | — | — |
| Pearl Investigative Site | Birmingham | Alabama | — | — |
| Pearl Investigative Site | Mesa | Arizona | — | — |
| Pearl Investigative Site | Phoenix | Arizona | — | — |
| Pearl Investigative Site | Scottsdale | Arizona | — | — |
| Pearl Investigative Site | Tucson | Arizona | — | — |
| Pearl Investigative Site | Anaheim | California | — | — |
| Pearl Investigative Site | Carlsbad | California | — | — |
| Pearl Investigative Site | Lakewood | California | — | — |
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| Pearl Investigative Site | Pasadena | California | — | — |
| Pearl Investigative Site | Poway | California | — | — |
| Pearl Investigative Site | Sacramento | California | — | — |
| Pearl Investigative Site | San Diego | California | — | — |
| Pearl Investigative Site | Tustin | California | — | — |
| Pearl Investigative Site | Vista | California | — | — |
| Pearl Investigative Site | Colorado Springs | Colorado | — | — |
| Pearl Investigative Site | Denver | Colorado | — | — |
| Pearl Investigative Site | Fort Collins | Colorado | — | — |
| Pearl Investigative Site | Wheat Ridge | Colorado | — | — |
| Pearl Investigative Site | Danbury | Connecticut | — | — |
| Pearl Investigative Site | Waterbury | Connecticut | — | — |
| Pearl Investigative Site | Brandon | Florida | — | — |
| Pearl Investigative Site | Clearwater | Florida | — | — |
| Pearl Investigative Site | Lehigh Acres | Florida | — | — |
| Pearl Investigative Site | Miami | Florida | — | — |
| Pearl Investigative Site | Ormond Beach | Florida | — | — |
| Pearl Investigative Site | Panama City | Florida | — | — |
| Pearl Investigative Site | Pensacola | Florida | — | — |
| Pearl Investigative Site | St. Petersburg | Florida | — | — |
| Pearl Investigative Site | Tampa | Florida | — | — |
| Pearl Investigative Site | Winter Park | Florida | — | — |
| Pearl Investigative Site | Atlanta | Georgia | — | — |
| Pearl Investigative Site | Austell | Georgia | — | — |
| Pearl Investigative Site | Columbus | Georgia | — | — |
| Pearl Investigative Site | Duluth | Georgia | — | — |
| Pearl Investigative Site | Gainesville | Georgia | — | — |
| Pearl Investigative Site | Coeur d'Alene | Idaho | — | — |
| Pearl Investigative Site | Champaign | Illinois | — | — |
| Pearl Investigative Site | Evanston | Illinois | — | — |
| Pearl Investigative Site | Peoria | Illinois | — | — |
| Pearl Investigative Site | River Forest | Illinois | — | — |
| Pearl Investigative Site | Anderson | Indiana | — | — |
| Pearl Investigative Site | Avon | Indiana | — | — |
| Pearl Investigative Site | Elwood | Indiana | — | — |
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| Pearl Investigative Site | Iowa City | Iowa | — | — |
| Pearl Investigative Site | Topeka | Kansas | — | — |
| Pearl Investigative Site | Louisville | Kentucky | — | — |
| Pearl Investigative Site | Lafayette | Louisiana | — | — |
| Pearl Investigative Site | Sunset | Louisiana | — | — |
| Pearl Investigative Site | Baltimore | Maryland | — | — |
| Pearl Investigative Site | Hollywood | Maryland | — | — |
| Pearl Investigative Site | Livonia | Michigan | — | — |
| Pearl Investigative Site | Southfield | Michigan | — | — |
| Pearl Investigative Site | Edina | Minnesota | — | — |
| Pearl Investigative Site | Fridley | Minnesota | — | — |
| Pearl Investigative Site | Minneapolis | Minnesota | — | — |
| Pearl Investigative Site | Woodbury | Minnesota | — | — |
| Pearl Investigative Site | Saint Charles | Missouri | — | — |
| Pearl Investigative Site | Springfield | Missouri | — | — |
| Pearl Investigative Site | St Louis | Missouri | — | — |
| Pearl Investigative Site | Missoula | Montana | — | — |
| Pearl Investigative Site | Bellevue | Nebraska | — | — |
| Pearl Investigative Site | Omaha | Nebraska | — | — |
| Pearl Investigative Site | Las Vegas | Nevada | — | — |
| Pearl Investigative Site | Ocean City | New Jersey | — | — |
| Pearl Investigative Site | Albuquerque | New Mexico | — | — |
| Pearl Investigative Site | Corning | New York | — | — |
| Pearl Investigative Site | Burlington | North Carolina | — | — |
| Pearl Investigative Site | Charlotte | North Carolina | — | — |
| Pearl Investigative Site | Greensboro | North Carolina | — | — |
| Pearl Investigative Site | Huntersville | North Carolina | — | — |
| Pearl Investigative Site | Raleigh | North Carolina | — | — |
| Pearl Investigative Site | Wilmington | North Carolina | — | — |
| Pearl Investigative Site | Winston-Salem | North Carolina | — | — |
| Pearl Investigative Site | Cincinnati | Ohio | — | — |
| Pearl Investigative Site | Columbus | Ohio | — | — |
| Pearl Investigative Site | Dayton | Ohio | — | — |
| Pearl Investigative Site | Dublin | Ohio | — | — |
| Pearl Investigative Site | Oregon | Ohio | — | — |
| Pearl Investigative Site | Bend | Oregon | — | — |
| Pearl Investigative Site | Medford | Oregon | — | — |
| Pearl Investigative Site | Portland | Oregon | — | — |
| Pearl Investigative Site | Monroeville | Pennsylvania | — | — |
| Pearl Investigative Site | Philadelphia | Pennsylvania | — | — |
| Pearl Investigative Site | Charleston | South Carolina | — | — |
| Pearl Investigative Site | Easley | South Carolina | — | — |
| Pearl Investigative Site | Gaffney | South Carolina | — | — |
| Pearl Investigative Site | Greenville | South Carolina | — | — |
| Pearl Investigative Site | Mt. Pleasant | South Carolina | — | — |
| Pearl Investigative Site | Murrells Inlet | South Carolina | — | — |
| Pearl Investigative Site | Myrtle Beach | South Carolina | — | — |
| Pearl Investigative Site | Rock Hill | South Carolina | — | — |
| Pearl Investigative Site | Spartanburg | South Carolina | — | — |
| Pearl Investigative Site | Union | South Carolina | — | — |
| Pearl Investigative Site | Rapid City | South Dakota | — | — |
| Pearl Investigative Site | Bristol | Tennessee | — | — |
| Pearl Investigative Site | Johnson City | Tennessee | — | — |
| Pearl Investigative Site | Kingsport | Tennessee | — | — |
| Pearl Investigative Site | Tullahoma | Tennessee | — | — |
| Pearl Investigative Site | Austin | Texas | — | — |
| Pearl Investigative Site | El Paso | Texas | — | — |
| Pearl Investigative Site | Fort Worth | Texas | — | — |
| Pearl Investigative Site | Houston | Texas | — | — |
| Pearl Investigative Site | Huntsville | Texas | — | — |
| Pearl Investigative Site | Longview | Texas | — | — |
| Pearl Investigative Site | Lufkin | Texas | — | — |
| Pearl Investigative Site | New Braunfels | Texas | — | — |
| Pearl Investigative Site | San Antonio | Texas | — | — |
| Pearl Investigative Site | Midvale | Utah | — | — |
| Pearl Investigative Site | Salt Lake City | Utah | — | — |
| Pearl Investigative Site | South Burlington | Vermont | — | — |
| Pearl Investigative Site | Abingdon | Virginia | — | — |
| Pearl Investigative Site | Richmond | Virginia | — | — |
| Pearl Investigative Site | Spokane | Washington | — | — |
| Pearl Investigative Site | Tacoma | Washington | — | — |
| Pearl Investigative Site | Morgantown | West Virginia | — | — |
| Pearl Investigative Site | West Allis | Wisconsin | — | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01854645, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 28, 2017 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01854645 live on ClinicalTrials.gov.