Glutathione and Fuel Oxidation in Aging
Public ClinicalTrials.gov record NCT01870193. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Glutathione is an important antioxidant protein which protects cells from harmful oxidative stress. Elderly humans are known to have elevated oxidative stress and deficiency of glutathione, but it is not known whether there is deficient synthesis of glutathione in muscle tissue of elderly humans. Mitochondria are engines of cells where food consumed is burned to make energy. Under normal conditions the fuel of choice in the fasted state is fat, but fasted elderly humans are not able to oxidize fat as well as healthy young humans. Elderly humans also have the highest incidence and prevalence of being overweight and obese, and have increased storage of fat in liver and muscle. This study will help determine whether 1. elderly humans have diminished synthesis of glutathione in the skeletal muscle, and whether this can be improved by supplementing cysteine and glycine (and not an isonitrogenous placebo) in the diet; 2. improving muscle glutathione concentrations can also improve fuel oxidation in aging; 3. improvement of intracellular glutathione concentrations will be associated with a change in total body fat content
Study identification
- NCT ID
- NCT01870193
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Early Phase 1
- Enrollment
- 36 participants
Conditions and interventions
Conditions
Interventions
- Glycine, cysteine (as n-acetylcysteine), alanine Dietary Supplement
Dietary Supplement
Eligibility (public fields only)
- Age range
- 21 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 22, 2013
- Primary completion
- Feb 28, 2019
- Completion
- Aug 21, 2022
- Last update posted
- Feb 14, 2023
2013 – 2022
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Baylor College of Medicine | Houston | Texas | 77030 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Recently updated Aging trials
Other public records listing Aging. Sorted by last update posted; newest first. Not a recommendation.
- NCT06879626: Effect of Snacks on Aging Active, not recruiting
- NCT06501820: Neural Control of Gait & Navigation in ADRD Recruiting
- NCT07731451: The Role of Brain Lactate Metabolism in Neuroprotection During Healthy Aging Not yet recruiting
- NCT07719088: Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life Not yet recruiting
- NCT07719049: Artificial Intelligence-Based Health Assessment From Face Photographs - Healthy Volunteer Study Recruiting
- NCT07461584: Memory Enhancement in Aging With Optimal Dosing Recruiting
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01870193, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 14, 2023 · Synced Sep 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT01870193 live on ClinicalTrials.gov.