A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive Participants With NMO (PREVENT Study)
Public ClinicalTrials.gov record NCT01892345. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Trial to Evaluate the Safety and Efficacy of Eculizumab in Patients With Relapsing Neuromyelitis Optica (NMO)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objectives of this time-to-event study were to assess the efficacy and safety of eculizumab as compared with placebo in participants with neuromyelitis optica spectrum disorder (NMOSD) who were anti-aquaporin-4 (AQP4) antibody-positive.
Study identification
- NCT ID
- NCT01892345
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 143 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 11, 2014 (Actual)
- Primary completion
- Jul 17, 2018 (Actual)
- Completion
- Jul 17, 2018 (Actual)
- Last update posted
- Jun 26, 2019
2014 – 2018
United States locations
- U.S. sites
- 19
- U.S. states
- 16
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | — |
| The Research Center of Southern California | Carlsbad | California | 92011 | — |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| University of Miami McKnight Brain Institute | Miami | Florida | 33136 | — |
| Neurological Services of Orlando | Orlando | Florida | 32806 | — |
| Fort Wayne Neurological Center | Fort Wayne | Indiana | 46804 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| John Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Multiple Sclerosis Comprehensive Care Center, NYU Langone Medical Center | New York | New York | 10016 | — |
| The Ohio State University, Wexner Medical Center, CarePoint at Gahanna | Gahanna | Ohio | 43230 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Multiple Sclerosis Treatment Center of Dallas | Dallas | Texas | 75246 | — |
| University of Utah Health Care | Salt Lake City | Utah | 84132 | — |
| Swedish Neuroscience Institute | Seattle | Washington | 98122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 51 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01892345, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 26, 2019 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01892345 live on ClinicalTrials.gov.