ClinicalTrials.gov record
Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)
ClinicalTrials.gov ID: NCT01897532
Public ClinicalTrials.gov record NCT01897532. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CARMELINA: A Multicenter, International, Randomized, Parallel Group, Double-blind, Placebo-controlled, Cardiovascular Safety and Renal Microvascular Outcome Study With Linagliptin, 5 mg Once Daily in Patients With Type 2 Diabetes Mellitus at High Vascular Risk
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The aim of the study is to investigate the longterm impact on cardiovascular morbidity, mortality and renal function of treatment with linagliptin in a selected population of patients with Type 2 diabetes mellitus (T2DM) and to compare outcomes against placebo, on a background of standard of care.
Study identification
- NCT ID
- NCT01897532
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 6,991 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 10, 2013 (Actual)
- Primary completion
- Jan 18, 2018 (Actual)
- Completion
- Jan 18, 2018 (Actual)
- Last update posted
- Apr 4, 2019
2013 – 2018
United States locations
- U.S. sites
- 197
- U.S. states
- 37
- U.S. cities
- 153
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Longwood Research | Huntsville | Alabama | 35801 | — |
| Scottsboro Quick Care Clinic | Scottsboro | Alabama | 35768 | — |
| Office of Dr. Terence T. Hart MD | Tuscumbia | Alabama | 35674 | — |
| Arrowhead Health Centers | Glendale | Arizona | 85306 | — |
| Precision Trials, LLC | Phoenix | Arizona | 85032 | — |
| Harrisburg Family Medical Center | Harrisburg | Arkansas | 72432 | — |
| Cardiology and Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| Little Rock Diagnostic Clinic | Little Rock | Arkansas | 72205 | — |
| Kaiser Permanente - San Diego, Bonita | Bonita | California | 91902 | — |
| John Muir Physician Network Clinical Research Center | Concord | California | 94520 | — |
| Valley Research | Fresno | California | 93720 | — |
| VA Loma Linda Healthcare System | Loma Linda | California | 92357 | — |
| Long Beach Center for Clinical Research | Long Beach | California | 90807 | — |
| Clearview Medical Research, LLC | Los Angeles | California | 90019 | — |
| National Research Institute | Los Angeles | California | 90057 | — |
| Office of Dr. Richard S. Cherlin | Los Gatos | California | 95032 | — |
| Coastal Medical Research Group | Los Osos | California | 93402 | — |
| Novo Research, Incorporated | Modesto | California | 95350 | — |
| Providence Clinical Research | North Hollywood | California | 91606 | — |
| Northridge Clinical Research Inc. | Northridge | California | 91324 | — |
| Carr Cardiology | Oceanside | California | 92056 | — |
| Center for Clinical Trials of Sacramento, Incorporated | Sacramento | California | 95823 | — |
| North America Research Institute | San Dimas | California | 91773 | — |
| Trinitas Research, Incorporated | San Jose | California | 95116 | — |
| Metabolic Institute of America | Tarzana | California | 91356 | — |
| Center for Clinical Trials of San Gabriel | West Covina | California | 91790 | — |
| Western Nephrology & Metabolic | Arvada | Colorado | 80002 | — |
| South Denver Nephrology | Denver | Colorado | 80210 | — |
| Colorado Center for Bone Research, P.C. | Golden | Colorado | 80401 | — |
| Helix Biomedics LLC | Boynton Beach | Florida | 33435 | — |
| Orthopedic Research Institute | Boynton Beach | Florida | 33437 | — |
| Nova Clinical Research, LLC | Bradenton | Florida | 34209 | — |
| PAB Clinical Research | Brandon | Florida | 33511 | — |
| Meridien Research | Brooksville | Florida | 34601 | — |
| Southeast Clinical Research, LLC | Chiefland | Florida | 32626 | — |
| BayCare Medical Group | Clearwater | Florida | 33756 | — |
| Cohen Medical Research Associates, LLC | Delray Beach | Florida | 33446 | — |
| Innovation Medical Research Center, Inc | Doral | Florida | 33166 | — |
| Integrative Research Associates | Fort Lauderdale | Florida | 33312 | — |
| Jellinger and Lerman, MD, PA dba The Center for Diabetes and Endocrine Care | Fort Lauderdale | Florida | 33312 | — |
| Direct Helpers Medical Center, Inc | Hialeah | Florida | 33012 | — |
| Universal Clinical Research | Hialeah | Florida | 33012 | — |
| Homestead Associates in Research | Homestead | Florida | 33032 | — |
| St. Vincent's Cardiology | Jacksonville | Florida | 32216 | — |
| Care Partners Clinical Research LLC | Jacksonville | Florida | 32277 | — |
| Altus Research, Inc. | Lake Clarke Shores | Florida | 33406 | — |
| Meridien Research | Lakeland | Florida | 33805 | — |
| Clinical Research of Miami | Miami | Florida | 33126 | — |
| Prestige Clinical Research Center, Inc. | Miami | Florida | 33133 | — |
| Jesscan Medical Research, Internal Medicine | Miami | Florida | 33134 | — |
| Clintex Research Group, Inc. Research | Miami | Florida | 33135 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Florida Medical Center & Research Inc | Miami | Florida | 33142 | — |
| A+ Research Incorporated | Miami | Florida | 33144 | — |
| Unlimited Medical Research, LLC | Miami | Florida | 33144 | — |
| Regenerate Clinical Trials | Miami | Florida | 33155 | — |
| Sanitas Research | Miami | Florida | 33155 | — |
| Future Care Solution, LLC | Miami | Florida | 33165 | — |
| Research Institute of South Florida Inc | Miami | Florida | 33173 | — |
| Tellus Clinical Research, Incorporated | Miami | Florida | 33173 | — |
| New Horizon Research Center | Miami | Florida | 33175 | — |
| Kendall South Medical Center, Inc | Miami | Florida | 33185 | — |
| Coral Research Clinic Corp | Miami | Florida | 33186 | — |
| Precision Research Organization | Miami Lakes | Florida | 33016 | — |
| School of Clinical Research | North Miami Beach | Florida | 33144 | — |
| Harmony Clinical Research, Incorporated | North Miami Beach | Florida | 33162 | — |
| Magnolia Research Group | Ocala | Florida | 34471 | — |
| Family Medical Center | Orlando | Florida | 32806 | — |
| Peninsula Research, Inc. | Ormond Beach | Florida | 32174 | — |
| Infinity Clinical Research, LLC | Plantation | Florida | 33317 | — |
| Intercoastal Medical Group, Endocrinology | Sarasota | Florida | 34232 | — |
| Meridien Research | St. Petersburg | Florida | 33709 | — |
| Professional Health Care of Pinellas, Inc. | St. Petersburg | Florida | 33713 | — |
| Meridien Research | Tampa | Florida | 33634 | — |
| Metabolic Research Institute | West Palm Beach | Florida | 33401 | — |
| Emory University | Atlanta | Georgia | 30303 | — |
| Laureate Clinical Research Group, LLC | Atlanta | Georgia | 30308 | — |
| Bainbridge Medical Associates | Bainbridge | Georgia | 39819 | — |
| Atlanta Heart Specialists, LLC | Cumming | Georgia | 30041 | — |
| McGarity, Jr., William C. | Decatur | Georgia | 30035-4000 | — |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | — |
| Belleville Family Medical Associates, Ltd | Belleville | Illinois | 62220 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Chicago Clinical Research Institute, Inc. | Chicago | Illinois | 60607 | — |
| Associates in Endocrinology, Incorporated | Elgin | Illinois | 60124 | — |
| Kidney Care Center, Nephrology | Joliet | Illinois | 60435 | — |
| American Health Network | Avon | Indiana | 46123 | — |
| American Health Network of Indiana, LLC | Franklin | Indiana | 46131 | — |
| American Health Network of Indiana, LLC | Greenfield | Indiana | 46140 | — |
| American Health Network of Indiana, LLC | Muncie | Indiana | 47304 | — |
| Buynak Clinical Research | Valparaiso | Indiana | 46383 | — |
| Northeast Iowa Medical Education Foundation | Waterloo | Iowa | 50702 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50265 | — |
| Cotton-O'Neil Clinical Research Center | Topeka | Kansas | 66606 | — |
| Professional Research Network of Kansas, LLC | Wichita | Kansas | 67203 | — |
| Heartland Research Associates, LLC | Wichita | Kansas | 67205 | — |
| The Research Group of Lexington, LLC | Lexington | Kentucky | 40503 | — |
| Diabetes and Metabolism Associates APMC | Metairie | Louisiana | 70006 | — |
| Tulane University Hospital and Clinic | New Orleans | Louisiana | 70112 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| Overlea Personal Physicians | Baltimore | Maryland | 21236 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Delmarva Heart Research Foundation, Inc | Salisbury | Maryland | 21804 | — |
| Endeavor Medical Research | Alpena | Michigan | 49707 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48105 | — |
| Aa Mrc Llc | Flint | Michigan | 48504 | — |
| McLaren Northern Michigan Hospital | Petoskey | Michigan | 49770 | — |
| Remedica LLC | Rochester | Michigan | 48307 | — |
| Tri-County Research, Inc | Sterling Heights | Michigan | 48310-3503 | — |
| Oakland Medical Research Center | Troy | Michigan | 48085 | — |
| HealthEast St. Joseph's Hospital | Saint Paul | Minnesota | 55102 | — |
| Mississippi Medical Research, LLC | Carriere | Mississippi | 39426 | — |
| Truman Medical Centers, Inc. | Kansas City | Missouri | 64108 | — |
| Kansas City Veterans Administration Medical Center | Kansas City | Missouri | 64128 | — |
| Glacier View Cardiology, PC | Kalispell | Montana | 59901 | — |
| Platte River Nephrology | North Platte | Nebraska | 69101 | — |
| Omaha Veterans Affairs Medical Center | Omaha | Nebraska | 68131 | — |
| Alas Science Clinical Research | Las Vegas | Nevada | 89120 | — |
| USMA Clin. Research/Union Square Med. Associates | Elizabeth | New Jersey | 07201 | — |
| Mount Sinai - PRIME | Linden | New Jersey | 07036 | — |
| New Mexico Clinical Research and Osteoporosis Center, Inc. | Albuquerque | New Mexico | 87106 | — |
| Life Medi-Research and Management | Brooklyn | New York | 11206 | — |
| United Medical Associates | Johnson City | New York | 13901 | — |
| Saratoga Clinical Research, LLC | Saratoga Springs | New York | 12866 | — |
| Jacobi Medical Center | The Bronx | New York | 10461 | — |
| Kernodle Clinic West | Burlington | North Carolina | 27215 | — |
| Main Street Physicians Care | Calabash | North Carolina | 28467 | — |
| Box Arthritis & Rheumatology of the Carolinas | Charlotte | North Carolina | 28210 | — |
| Clinical Research of Gastonia | Gastonia | North Carolina | 28054 | — |
| Medication Management, LLC | Greensboro | North Carolina | 27408 | — |
| PMG Research of Bristol, LLC | Hickory | North Carolina | 28601 | — |
| Novant Health Southern Piedmont Primary Care | Monroe | North Carolina | 28110 | — |
| Research Institute of the Carolinas, PLC | Mooresville | North Carolina | 28117 | — |
| Down East Medical Associates | Morehead City | North Carolina | 28557 | — |
| Burke Primary Care | Morganton | North Carolina | 28655 | — |
| PMG Research of Salisbury, LLC | Salisbury | North Carolina | 28144 | — |
| Natalie A Doyle, M.D., P.A. | Wilson | North Carolina | 27893 | — |
| Summa Health System | Akron | Ohio | 44304 | — |
| Medical Frontiers, LLC | Carlisle | Ohio | 45005 | — |
| Dayton VA Medical Center | Dayton | Ohio | 45428 | — |
| Norton Community Care | Norton | Ohio | 44203 | — |
| Apex Medical Research, AMR, Incorporated | Springfield | Ohio | 45505 | — |
| ProMedica Health Education & Research Corp. | Toledo | Ohio | 43606 | — |
| COR Clinical Research, LLC | Oklahoma City | Oklahoma | 73103 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| The Corvallis Clinic, PC | Corvallis | Oregon | 97330 | — |
| Blair Medical Associates | Altoona | Pennsylvania | 16602 | — |
| Clinical Research Associates of Central Pennsylvania | Altoona | Pennsylvania | 16602 | — |
| Central Bucks Cardiology | Doylestown | Pennsylvania | 18901 | — |
| Doylestown Health Cardiology | Doylestown | Pennsylvania | 18901 | — |
| Lycoming Internal Medicine, Inc | Jersey Shore | Pennsylvania | 17740 | — |
| Montgomery Medical Incorporated | Smithfield | Pennsylvania | 15478 | — |
| Clinical Trials of South Carolina | Charleston | South Carolina | 29406 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Spectrum Medical Research, LLC | Gaffney | South Carolina | 29341 | — |
| VitaLink Research | Greenville | South Carolina | 29615 | — |
| Mountain View Clinical Research | Greer | South Carolina | 29651 | — |
| Vita Link Research- Rock Hill | Rock Hill | South Carolina | 29732 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Holston Medical Group | Bristol | Tennessee | 37620 | — |
| State of Franklin Healthcare Associates, PLLC | Johnson City | Tennessee | 37604 | — |
| DCT- AACT, LLC dba Discovery Clinical Trials | Austin | Texas | 78758 | — |
| Rockwood Medical Clinic | Bedford | Texas | 76022 | — |
| Texas Health Physicians Group | Dallas | Texas | 75218 | — |
| Research Institute of Dallas | Dallas | Texas | 75231 | — |
| Ben Taub General Hospital | Houston | Texas | 77030 | — |
| Southwest Clinical Trials | Houston | Texas | 77074 | — |
| The Endocrine Center | Houston | Texas | 77079 | — |
| Texas Family Geriatrics Clinic | Houston | Texas | 77082 | — |
| Memorial Clinical Associates Research | Houston | Texas | 77084 | — |
| Break Through Medical Research | Irving | Texas | 75039 | — |
| Medical & Surgical Clinic | Irving | Texas | 75061 | — |
| West Memorial Family Practice | Katy | Texas | 77450 | — |
| Hill Country Medical Associates | New Braunfels | Texas | 78130 | — |
| Permian Research Foundation | Odessa | Texas | 79761 | — |
| Methodist Hospital Research Institute, Internal Medicine | Pearland | Texas | 77584 | — |
| Health Texas Research Institute | San Antonio | Texas | 78228-6205 | — |
| Covenant Clinical Research, PA | San Antonio | Texas | 78229 | — |
| DM Clinical Research | San Antonio | Texas | 78249 | — |
| DCT-Stone Oak, LLC dba Discovery Clinical Trials | San Antonio | Texas | 78258 | — |
| Sealy Urgent Care Center and Medical Clinic | Sealy | Texas | 77474 | — |
| Pioneer Research Solutions, Inc. | Sugar Land | Texas | 77479 | — |
| DM Clinical Research | Tomball | Texas | 77375 | — |
| Crossroads Clinical Research, LLC | Victoria | Texas | 77901 | — |
| Ericksen Research & Development, LLC | Clinton | Utah | 84015 | — |
| Focus Clinical Research | Draper | Utah | 84020 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| Paramount Medical Care | Ogden | Utah | 84405 | — |
| Burke Internal Medicine and Research | Burke | Virginia | 22015 | — |
| Nova Health Management & Research Group, PC | Herndon | Virginia | 20170 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Dominion Medical Associates, Inc. | Richmond | Virginia | 23219 | — |
| Hunter Holmes McGuire Veterans Administration Medical Center | Richmond | Virginia | 23249 | — |
| Roanoke Heart Institute PLC | Roanoke | Virginia | 24014 | — |
| Salem Veterans Affairs Medical Center | Salem | Virginia | 24153 | — |
| Sound Medical Research | Port Orchard | Washington | 98366 | — |
| Zablocki VA Medical Center | Milwaukee | Wisconsin | 53295 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 452 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT01897532, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 4, 2019 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT01897532 live on ClinicalTrials.gov.